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The carcinogenic potential of several periodontal pathogens has been substantiated in\u00a0vitro and in\u00a0vivo. This review provides a comprehensive overview of the diverse mechanisms employed by different periodontal pathogens in the development of cancer. These mechanisms induce chronic inflammation, inhibit the host's immune system, activate cell invasion and proliferation, possess anti\u2010apoptotic activity, and produce carcinogenic substances. 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