{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:57:51Z","timestamp":1792634271964,"version":"4.5.0"},"reference-count":124,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To provide an overview of the use of autogenous platelet concentrates (APCs) in periodontal regeneration and to conduct a systematic review (SR) of the treatment outcomes of periodontal intrabony defects by using platelet\u2010rich fibrin (PRF) compared with other commonly utilized modalities. The eligibility criteria comprised randomized controlled trials (RCTs) comparing the clinical outcomes of PRF with that of other modalities. Studies were classified into 21 categories and into five different groups as follows: Group I (1) open flap debridement (OFD) alone versus OFD\/PRF, (2) OFD versus Titanium\u2010PRF (T\u2010PRF) Group II, (3) Comparative PRF protocols (PRF vs. T\u2010PRF), Group III (Comparative Studies to PRF): (4) OFD\/PRP versus OFD\/PRF, (5) OFD\/bone graft(BG)\/PRGF versus OFD\/BG\/PRF, (6) OFD\/EMD versus OFD\/PRF, (7) OFD\/BG\/EMD versus OFD\/BG\/PRF, (8) OFD\/collagen membrane (CM) versus OFD\/PRF, (9) OFD\/BG\/BM versus OFD\/BG\/PRF, (10) OFD\/BG versus OFD\/PRF, Group IV (Addition of PRF to treatment groups) (11) OFD\/BG versus OFD\/BG\/PRF, (12) OFD\/GTR versus OFD\/GTR\u2009+\u2009PRF (13) OFD\/EMD versus OFD\/EMD\/PRF (14) OFD\/BG\/BM versus OFD\/BG\/BM\/PRF, Group V (Addition of Biomaterial\/Biomolecule to PRF): OFD\/PRF versus \u2026 (15) OFD\/PRF\/BG, (16) OFD\/PRF\/antibiotic, (17) OFD\/PRF\/Metformin, (18) OFD\/PRF\/Bisphosphonates, (19) OFD\/PRF\/Statins, (20) OFD\/BG\/PRF versus OFD\/BG\/PRF\/Statins, and (21) OFD\/PRF\/low\u2010level laser therapy (LLLT). Weighted means and forest plots were calculated for probing pocket depth (PPD), clinical attachment level (CAL), and radiographic bone fill (RBF). From 596 records identified, 55 RCTs were included. Group I: The use of OFD\/PRF statistically significantly reduced PPD and improved CAL and RBF when compared to OFD. Group II: A significant difference between various PRF protocols was only observed for PPD. Group III: No significant advantage was found when comparing OFD\/PRF to the following groups: OFD\/PRP, OFD\/EMD, OFD\/BM, or OFD\/BG. Group IV: The addition of PRF to OFD\/BG led to significant improvements in PPD, CAL and RBF compared with OFD\/BG alone. Group V: The addition of either a BG as well as three of the following biomolecules (metformin, bisphosphonates, and statins) to OFD\/PRF led to statistically significant improvements in PPD, CAL, and\/or RBF when compared to OFD\/PRF alone. The use of PRF significantly improved clinical outcomes in intrabony defects when compared to OFD alone. Similar results were observed when OFD\/PRF was compared with OFD\/BG, OFD\/EMD, OFD\/PRP, and OFD\/BM. The addition of PRF to a bone grafting material as well as the addition of various small biomolecules to PRF may offer additional clinical advantages, thus warranting further investigations. Future research investigating various protocols of PRF, longer\u2010term outcomes, as well as PRF at the human histological level remains needed.<\/jats:p>","DOI":"10.1111\/prd.12598","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T07:49:27Z","timestamp":1729324167000},"page":"153-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Autogenous platelet concentrates for treatment of intrabony defects\u2014A systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"97","author":[{"given":"Richard J.","family":"Miron","sequence":"first","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Moraschini","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, School of Dentistry, Fluminense Federal University Niter\u00f3i  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Estrin","sequence":"additional","affiliation":[{"name":"School of Dental Medicine Lake Erie College of Osteopathic Medicine  Bradenton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil Awad","family":"Shibli","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry, School of Dentistry Guarulhos University  Guarulhos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Cosgarea","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Operative and Preventive Dentistry University of Bonn  Bonn Germany"},{"name":"Department of Periodontology University of Marburg  Germany"},{"name":"Faculty of Dentistry University Iuliu Hatieganu Cluj\u2010Napoca  Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Operative and Preventive Dentistry University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia\u2010Merete","family":"Jerv\u00f8e\u2010Storm","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Operative and Preventive Dentistry University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-1799","authenticated-orcid":false,"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Operative and Preventive Dentistry University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0721"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb00435.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02095.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.12.683"},{"key":"e_1_2_11_6_1","first-page":"19","article-title":"Human histologic evaluation of a bovine\u2010derived bone xenograft in the treatment of periodontal osseous defects","volume":"20","author":"MeIIonig JT","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00785.x"},{"key":"e_1_2_11_8_1","first-page":"171","article-title":"Human histologic and clinical evaluation of recombinant human platelet\u2010derived growth factor and beta\u2010tricalcium phosphate for the treatment of periodontal intraosseous defects","volume":"28","author":"Ridgway HK","year":"2008","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13237"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13639"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00317.x"},{"key":"e_1_2_11_13_1","first-page":"180","article-title":"Long\u2010term outcomes of periodontal regenerative procedures for the treatment of Intrabony periodontal defects: a systematic review and meta\u2010analysis","volume":"23","author":"Nam K","year":"2021","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12117"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-016-0261-5"},{"key":"e_1_2_11_16_1","article-title":"Autologous platelet concentrates for treating periodontal infrabony defects","volume":"11","author":"Del Fabbro M","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9594235"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00223"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-012-9349-6"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2063-9"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2133-z"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36346"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-018-0708-8"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8670832"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_684_20"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0120"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2023.08.007"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110705"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1719-1"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160443"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12643"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6669168"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014759"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03825-8"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-017-0079-5"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7647"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-7-16"},{"key":"e_1_2_11_39_1","unstructured":"Grey Literature Report. The New York Academy of Medicine. Avaiable at:http:\/\/www.greylit.org. Accessed May 10 2020.Natl J Maxillofac Surg; 7: 45\u201351."},{"key":"e_1_2_11_40_1","unstructured":"Open Grey. Avaiable at:http:\/\/www.opengrey.eu. Accessed May 10 2020."},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604.ch8"},{"key":"e_1_2_11_43_1","volume-title":"Systematic Reviews in Health Care: Meta\u2010Analysis in Context","author":"Egger M","year":"2008"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110075"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01760.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdj.2012.10.003"},{"key":"e_1_2_11_47_1","first-page":"32","article-title":"Comparative evaluation of platelet\u2010rich fibrin biomaterial and open flap debridement in the treatment of two and three wall intrabony defects","volume":"7","author":"Ajwani H","year":"2015","journal-title":"J Int Oral Health"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140646"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0762.189753"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150698"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150306"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160015"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.120661"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12231"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.130710"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110722"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2972"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.201628"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.11.027"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2021.101545"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-022-04627-2"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-03332-0"},{"key":"e_1_2_11_63_1","first-page":"808","article-title":"Evaluation of platelet\u2010rich fibrin in the treatment of decorticated intrabony defects: a randomized clinical trial","volume":"54","author":"Ugale GM","year":"2023","journal-title":"Quintessence Int"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.23231"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.34172\/joddd.2020.020"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150314"},{"key":"e_1_2_11_67_1","first-page":"86","article-title":"Efficacy of platelet\u2010rich fibrin vs. enamel matrix derivative in the treatment of periodontal intrabony defects: a clinical and cone beam computed tomography study","volume":"16","author":"Gupta SJ","year":"2014","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01925-1"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0533"},{"key":"e_1_2_11_70_1","first-page":"28","article-title":"Platelet\u2010rich fibrin for the treatment of intrabony periodontal defects in patients with generalized aggressive periodontitis: a randomized controlled clinical study","volume":"19","author":"Aggour RL","year":"2017","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0305"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.4103\/1305-7456.149653"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160309"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.195634"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_1147_16"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.115663"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.148639"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2015.1035672"},{"key":"e_1_2_11_79_1","article-title":"Comparative evaluation of bioactive glass putty and platelet rich fibrin in the treatment of human periodontal intrabony defects: a randomized control trial","volume":"11","author":"Naqvi A","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2017.vol31.0015"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0416"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_507_18"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_99_19"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_351_19"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_101_20"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_621_19"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-04954-y"},{"key":"e_1_2_11_88_1","first-page":"472","article-title":"Clinical and radiographic evaluation of platelet rich fibrin and bone graft material (\u03b2\u2010tricalcium phosphate+ hydroxyapatite) in the treatment of intrabony defects of periodontitis patients\u2010a randomized controlled trial","volume":"54","author":"Baghele O","year":"2023","journal-title":"Quintessence Int"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_268_22"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002524"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12598"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0860"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01446.x"},{"key":"e_1_2_11_94_1","first-page":"471","article-title":"A randomized comparative study of platelet\u2010rich fibrin along with hydroxyapatite graft for the treatment of 3\u2010walled defects in chronic periodontitis","volume":"94","author":"Thetay AA","year":"2021","journal-title":"Med Pharm Rep"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03929-1"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_740_20"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2020.71"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_300_22"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_562_18"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36734"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12714"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0216"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36792"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12529"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.05.021"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000204762.39826.0f"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.9.1601"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2011.00740.x"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.12.032"},{"key":"e_1_2_11_110_1","first-page":"61","article-title":"Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. Diabetic ulcer study group","volume":"183","author":"Steed DL","year":"1996","journal-title":"J Am Coll Surg"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.5.822"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-007-0422-x"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511435260"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.06.030"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(00)00232-7"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00145-5"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.05.026"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(02)00463-7"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2016.0233"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12526"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.4103\/GFSC.GFSC_23_18"},{"key":"e_1_2_11_122_1","first-page":"817","volume-title":"Standardization of Relative Centrifugal Forces in Studies Related to Platelet\u2010Rich Fibrin","author":"Miron RJ","year":"2019"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1754382"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01497-0"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12521"}],"container-title":["Periodontology 2000"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.12598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T09:54:26Z","timestamp":1739267666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/prd.12598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,19]]},"references-count":124,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/prd.12598"],"URL":"https:\/\/doi.org\/10.1111\/prd.12598","archive":["Portico"],"relation":{},"ISSN":["0906-6713","1600-0757"],"issn-type":[{"value":"0906-6713","type":"print"},{"value":"1600-0757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,19]]},"assertion":[{"value":"2024-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}