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The included papers summarize scientific evidence and the clinical findings, presented in simple tables that outline potential benefits including Patient Reported Outcome Measures (PROMs). This approach enables clinicians to assess clinical relevance and researchers to identify significant gaps in the literature. The first part provides a comprehensive summary of the basic science surrounding APC, with particular focus on their preparation methods. Clear recommendations are outlined, which are crucial for obtaining high\u2010quality APCs, alongside an exploration of how APCs may influence both soft and hard tissue healing processes. Part 2 delves into the clinical evidence for the potential benefits of APCs across a range of applications: alveolar ridge preservation, sinus floor elevation, periodontal plastic surgery, guided tissue regeneration, guided bone regeneration, the healing of Medication\u2010Related Osteonecrosis of the Jaw (MRONJ), and endodontic surgery. In the part 3, the discussion turns to the effects of APCs on the healing of extra\u2010oral wounds, including diabetic foot ulcers, venous leg ulcers, pressure injuries, burns, and more. The fourth section offers a detailed, step\u2010by\u2010step flowchart for each treatment modality, providing a clear guide for clinical application.<\/jats:p>","DOI":"10.1111\/prd.12607","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T09:19:27Z","timestamp":1726046367000},"page":"7-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Introduction and overview on Autogenous Platelet Concentrates"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-3908","authenticated-orcid":false,"given":"Marc","family":"Quirynen","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences, KU Leuven &amp; Dentistry (Periodontology) University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5477","authenticated-orcid":false,"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9251-513X","authenticated-orcid":false,"given":"Juan","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Surgery (Stomatology, Unit of Periodontology) Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-1799","authenticated-orcid":false,"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine The University of Michigan, School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-9073","authenticated-orcid":false,"given":"Nikos","family":"Donos","sequence":"additional","affiliation":[{"name":"Institute of Dentistry, Centre for Oral Clinical Research, Barts and The London School of Medicine and Dentistry Queen Mary University of London (QMUL)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0361"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2008.11.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.32098\/mltj.01.2014.02"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2019.06.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11100944"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12550"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(97)90187-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90029-4"},{"key":"e_1_2_8_10_1","first-page":"529","article-title":"Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants","volume":"14","author":"Anitua E","year":"1999","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_11_1","first-page":"55","article-title":"Une opportunit\u00e9 en paro\u2010implantologie: le PRF","volume":"42","author":"Choukroun J","year":"2001","journal-title":"Implant Dent"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12555"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12526"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12546"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12565"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12570"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/prd.12609","article-title":"The use of autologous Platelet concentrates (APCs) in alveolar ridge preservation (ARP): a systematic review & meta\u2010analyses","volume":"97","author":"Siawach SAM","year":"2025","journal-title":"Periodontol 2000"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12604"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/prd.12600","article-title":"Autologous Platelet concentrates after 3rd molar extraction: a systematic review","volume":"97","author":"Siawach SAM","year":"2025","journal-title":"Periodontol 2000"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12554"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12039"},{"key":"e_1_2_8_22_1","article-title":"Periodontal regeneration using platelet\u2010rich fibrin. 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