{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:43:34Z","timestamp":1788857014929,"version":"build-2803163510"},"reference-count":101,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Medication\u2010related osteonecrosis of the jaw (MRONJ) is an infectious side effect associated with bisphosphonates and monoclonal antibodies (denosumab, immune modulators, and antiangiogenic medications). Adjunctive therapies for the surgical management of MRONJ include autologous platelet concentrates (APCs). These APCs serve as a source of various cells and growth factors that aid tissue healing and regeneration. This review evaluated the use of platelet\u2010rich plasma (PRP), plasma\u2010rich in growth factors (PRGF), and leukocyte\u2010 and platelet\u2010rich fibrin (L\u2010PRF) as adjuvant therapies for the surgical management of MRONJ by conducting analyses on the results of 58 articles. Compared to surgical treatment alone, the application of PRP and L\u2010PRF after surgery appears to increase healing in the management of patients with MRONJ. No studies have reported unhealed lesions as a result of surgical treatment of MRONJ with PRGF application or compared it with surgical treatment alone. The overall results of this review have shown favorable healing rates of MRONJ lesions managed with the application of APCs after surgical treatment; however, significant methodological limitations may limit the scientific evidence supporting their use. Further randomized controlled trials with strict criteria are needed to establish the extent to which APCs can improve wound healing and quality of life in patients with MRONJ requiring surgical treatment.<\/jats:p>","DOI":"10.1111\/prd.12608","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T12:35:16Z","timestamp":1727699716000},"page":"287-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Autologous platelet concentrates as adjuvant in the surgical management of medication\u2010related osteonecrosis of the jaw"],"prefix":"10.1111","volume":"97","author":[{"given":"Francesco","family":"Bennardo","sequence":"first","affiliation":[{"name":"School of Dentistry Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Barone","sequence":"additional","affiliation":[{"name":"School of Dentistry Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Antonelli","sequence":"additional","affiliation":[{"name":"School of Dentistry Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amerigo","family":"Giudice","sequence":"additional","affiliation":[{"name":"School of Dentistry Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2022.02.008"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.11.012"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.23191"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14681"},{"key":"e_1_2_14_6_1","volume-title":"Raccomandazioni clinico\u2010terapeutiche sull'osteonecrosi delle ossa mascellari (ONJ) farmaco\u2010relata e sua prevenzione","author":"Campisi G","year":"2020"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104659"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2015.06.001"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-018-0474-4"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20963"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2019.06.004"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2684924"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2018.01.012"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.10.015"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.05.004"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.01.014"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.12.051"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.12.004"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.07.027"},{"issue":"7","key":"e_1_2_14_20_1","article-title":"Interventions for managing medication\u2010related osteonecrosis of the jaw","volume":"7","author":"Beth\u2010Tasdogan NH","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3191"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.09.024"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2007.0294"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181f4ee4e"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12306-018-0548-6"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-009-0047-9"},{"issue":"1","key":"e_1_2_14_27_1","first-page":"151","article-title":"Platelet\u2010rich plasma improves wound healing in multiple myeloma bisphosphonate\u2010associated osteonecrosis of the jaw patients","volume":"26","author":"Coviello V","year":"2012","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.02.078"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1563\/1548-1336(2007)33[371:UOPPIT]2.0.CO;2"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.15171\/jlms.2018.19"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.04.032"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/298945"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.08.010"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12023"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.04.020"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3982540"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2012.08.018"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-18-00254"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2019.100208"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.24007"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/ors.12318"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2020.05.024"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj9050050"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2019.02.011"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2016.08.007"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-019-01278-x"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdr.IJDR_689_19"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2016.1203093"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.105852"},{"issue":"3","key":"e_1_2_14_50_1","first-page":"811","article-title":"Platelet rich fibrin in the management of medication\u2010related osteonecrosis of the jaw: a clinical and histopathological evaluation","volume":"31","author":"Inchingolo F","year":"2017","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11083365"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201600662"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2017.06.004"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000009059"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18031018"},{"issue":"2","key":"e_1_2_14_56_1","first-page":"213","article-title":"Report of a jaw osteonecrosis possibly caused by denosumab","volume":"10","author":"Saad D","year":"2017","journal-title":"Eur J Oral Implantol"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000005472"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2015.10.005"},{"issue":"3","key":"e_1_2_14_59_1","first-page":"961","article-title":"Clinical and histopathological studies using fibrin\u2010rich plasma in the treatment of bisphosphonate\u2010related osteonecrosis of the jaw","volume":"55","author":"Dinc\u0103 O","year":"2014","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01965-7"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2021.04.004"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2019.12.008"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113505"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000005475"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000009161"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000007981"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2014.07.256"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.04.010"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2020.023"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.06.007"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03766-8"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adoms.2021.100076"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.25733"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2021.01.015"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.te41"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13160"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.12.014"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2020.05.037"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2019.07.012"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13334"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2008.11.009"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1430357"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2016.0233"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115117"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0553"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2673-x"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03022-8"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-022-04496-9"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.06.044"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7855497"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S200455"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e03795"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15720-7"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03420-3"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.011"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06473-4"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-02814-5"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2022.115167"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1080\/13668250600876392"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1136\/medethics-2011-100080"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12703"}],"container-title":["Periodontology 2000"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.12608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T09:56:33Z","timestamp":1739267793000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/prd.12608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/prd.12608"],"URL":"https:\/\/doi.org\/10.1111\/prd.12608","archive":["Portico"],"relation":{},"ISSN":["0906-6713","1600-0757"],"issn-type":[{"value":"0906-6713","type":"print"},{"value":"1600-0757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"2023-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}