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PubMed, EMBASE, Web of Science, and Scopus were screened for randomized controlled trials (RCTs) that were released prior to 2024. The selected papers compared an APC with either unassisted healing (blood clot) or another biomaterial during ARP (third molars were not included). The outcome parameters included alveolar bone dimension alterations, soft tissue healing, and post\u2010op pain intensity. The search yielded 35 papers (33 studies), one applying platelet\u2010rich plasma (PRP), six using plasma rich in growth factors (PRGF), and 28 using leukocyte\u2010 and platelet\u2010rich fibrin (L\u2010PRF). These studies showed a large heterogeneity (e.g., outcome parameters, timing, surgical approach, and inclusion criteria), which hindered drawing strong conclusions. In most studies, however, ARP with PRP, PRGF, and L\u2010PRF alone produced faster soft tissue healing, less post\u2010extraction pain, less alveolar ridge resorption, more socket bone fill, and a higher bone density when compared to unassisted (spontaneous) healing. The ultimate benefit appears to be significantly influenced by the surgical approach. Limited literature exists comparing APC with other biomaterials for ARP, resulting in inconclusive data. APC application for ARP is a promising strategy to improve soft and hard tissue healing and reduce post\u2010extraction pain.<\/jats:p>","DOI":"10.1111\/prd.12609","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T12:19:15Z","timestamp":1727698755000},"page":"104-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Autologous platelet concentrates in alveolar ridge preservation: A systematic review with meta\u2010analyses"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5860-761X","authenticated-orcid":false,"given":"Sayed Ahmad Manoetjer","family":"Siawasch","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences, Periodontology, KU Leuven &amp; Dentistry University Hospitals Leuven  Leuven 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