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A comprehensive search was conducted in PubMed, Scopus, and Web of Science up to September 30, 2024. Following a thorough screening process, studies were divided into in\u00a0vitro, in\u00a0vivo, and clinical studies based on their tissue\/clinical indications. The initial search generated 2192 articles, of which 23 met the inclusion criteria. The findings demonstrated that i\u2010PRF yielded higher platelet concentrations and offered a more sustained, long\u2010term release of growth factors over time when compared to PRP. Overall, it was determined from in\u00a0vitro studies that i\u2010PRF significantly improved the activity of many cell types, including for skin, cartilage, periodontal, bone, soft tissue around dental implants, and pulp cells. In\u00a0vivo outcomes also generally indicated that i\u2010PRF outperformed PRP in cartilage and testicular regeneration. However, in orthodontic tooth movement, PRP was found to lead to superior short\u2010term effects, while i\u2010PRF showed more beneficial long\u2010term effects. Clinical studies also found superior outcomes of i\u2010PRF in skin regeneration, cartilage, and pulp regeneration. Outcomes regarding orthodontic tooth movement utilizing i\u2010PRF or PRP remain controversial. In 72% of studies, i\u2010PRF was found to lead to better outcomes across the various fields of medicine when compared to PRP, whereas 24% found no differences between the groups. Reasons and inconsistencies across the studies may be attributed to protocol differences and tissue types. Overall, additional clinical studies are needed with well\u2010designed research and centrifugation protocols to better understand the regenerative potential of platelet concentrates in medicine. i\u2010PRF offers a more sustained and prolonged release of growth factors and was favored in the majority of studies over PRP and should, therefore, be favored for the majority of medical and dental applications.<\/jats:p>","DOI":"10.1111\/prd.12626","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T21:49:53Z","timestamp":1742852993000},"page":"185-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Platelet\u2010rich plasma (\n                    <scp>PRP<\/scp>\n                    ) versus injectable platelet\u2010rich fibrin (i\u2010\n                    <scp>PRF<\/scp>\n                    ): A systematic review across all fields of medicine"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-5305","authenticated-orcid":false,"given":"Nima","family":"Farshidfar","sequence":"first","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amin","family":"Amiri","sequence":"additional","affiliation":[{"name":"Oral and Dental Disease Research Center, School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan E.","family":"Estrin","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine School of Dental Medicine  Bradenton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paras","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Research Advanced PRF Education  Jupiter Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-5291","authenticated-orcid":false,"given":"Yufeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology University of Wuhan  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Miron","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern 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