{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:09:45Z","timestamp":1777633785061,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The primary goal of periodontology is to prevent tooth loss and reduce the risk of focal infections. Periodontitis lesions can harbor hundreds of thousands of active cytomegaloviruses (virions), which can easily enter the systemic circulation and potentially infect the fetus of a mother with compromised immunity. The healthy, non\u2010inflamed periodontium contains no PCR\u2010detectable cytomegalovirus. Maternal cytomegalovirus may be linked to cleft lip and cleft palate, prepubertal and juvenile periodontitis, and systemic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This article presents an anti\u2010cytomegalovirus periodontal therapy aimed at preventing congenital cytomegalovirus disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Immunodeficient and periodontitis\u2010affected women in the pre\u2010gestational period or the first trimester of pregnancy are prime candidates for periodontal treatment. The periodontal diagnosis and drug treatment ought to be performed by well\u2010informed dentists (periodontists). Treatment consists of a one\u2010time valacyclovir regimen (1\u2009g BID on days 1 and 2, and 500\u2009mg BID on days 3\u20137), subgingival and supragingival ultrasonic scaling using a 0.1%\u20130.2% sodium hypochlorite cooling solution, individually tailored oral hygiene instructions, and patient\u2010administered daily subgingival irrigation with a 0.1%\u20130.2% sodium hypochlorite solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cytomegalovirus in maternal periodontitis likely serves as a critical nidus for fetal infection. The combined treatment of valacyclovir, ultrasonic scaling, and sodium hypochlorite rinses markedly reduces or eliminates the mother\u2019s periodontal cytomegaloviruses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>The proposed noninvasive anti\u2010cytomegalovirus periodontal therapy is highly safe for the pregnant mother and the fetus. The anti\u2010cytomegalovirus periodontal treatment is expected to control the mother\u2019s periodontal cytomegalovirus load and, consequently, part of the baby\u2019s congenital disease risk. Research is encouraged on the relationship between periodontal cytomegalovirus and congenital diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.12632","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T06:29:01Z","timestamp":1750400941000},"page":"214-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between maternal periodontitis and congenital cytomegalovirus: A hypothetical model and therapeutic implications"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1423-0363","authenticated-orcid":false,"given":"J\u00f8rgen","family":"Slots","sequence":"first","affiliation":[{"name":"Division of Periodontology and Diagnostic Sciences University of Southern California School of Dentistry  Los Angeles California 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