{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:21:54Z","timestamp":1791645714954,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To quantify long\u2010term (\u2265 5 years) implant survival after lateral sinus floor elevation (LSFE) and to identify clinical predictors of long\u2010term survival using conventional and machine\u2010learning meta\u2010analytic techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted through MEDLINE, Embase and Scopus. Randomized trials, prospective or retrospective studies with \u2265 10 patients and \u2265 5\u2010year follow\u2010up were eligible. Risk of bias was assessed with RoB\u20102 (RCTs) and the Newcastle\u2013Ottawa Scale (observational studies); certainty of evidence was graded with GRADE approach. A multilevel random\u2010effects meta\u2010analysis (logit\u2010transformed proportions) estimated pooled survival while accounting for clustering of multiple implants per patient. Moderator effects were explored by mixed\u2010effects meta\u2010regression. A MetaForest machine\u2010learning model examined non\u2010linear interactions among predictive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010two studies (48 cohorts) involving 7,902 implants and \u2248 2,800 patients met the criteria (3 RCTs, 7 prospective non\u2010randomized, and 22 retrospective studies; follow\u2010up 5\u201313 years). Pooled long\u2010term survival was 95.8 % (95 % CI: 94.5\u201396.8 %); Heterogeneity was substantial (I\u00b2 = 82.8 %) but fell to 53.2 % in MetaForest residuals. Meta\u2010regression identified lower survival with Graftless procedures versus allografts(\u03b2 = 1.11, p = 0.016), autografts(\u03b2 =2.40, p = 0.005), Xenografts(\u03b2 =1.53, p = 0.04), Xenografts+Allografts(\u03b2 =1.55, p = 0.04) and Xenografts+Autografts(\u03b2 =1.82, p = 0.03) with no significant difference versus Alloplasts. Residual bone height (RBH) &lt; 4 mm (\u03b2 = \u20130.53, p = 0.039) as well as smoking prevalence (1.96 % per 10 % increase, p = 0.009) reduced survival. MetaForest ranked smoking, age, RBH, follow\u2010up duration and membrane use as the principal predictors; barrier membranes mitigated the negative effect in smokers and in low\u2010RBH sites. Time\u2010to\u2010failure analysis of 205 failed implants showed 59 % of losses within the first year and 96 % by year 5. Overall certainty of evidence was low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Implants placed after LSFE exhibit high 5\u201313\u2010year survival (96 %). Use of bone graft materials and their mixtures yield more favorable outcomes compared to Graftless protocol, whereas RBH &lt; 4 mm and smoking significantly impair implant survival. Barrier\u2010membrane coverage is advisable for smokers and short\u2010RBH sites. Despite the long\u2010term nature of this review (\u22655 years of follow\u2010up), most failures occur within the first three years of function, underscoring the need for intensified monitoring during this early phase.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.70028","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:04:26Z","timestamp":1774487066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term outcomes of lateral sinus floor elevation: A machine\u2010learning analysis, systematic review, and meta\u2010analysis of predictive factors"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-2104","authenticated-orcid":false,"given":"Hamoun","family":"Sabri","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Periodontics and Oral Implantology Advanced Computing and Artificial Intelligence (PICO.AI)  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5067-7317","authenticated-orcid":false,"given":"Muhammad H. A.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6177-3000","authenticated-orcid":false,"given":"Paolo","family":"Nava","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Periodontics and Oral Implantology Advanced Computing and Artificial Intelligence (PICO.AI)  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Scaini","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"IRCCS Orthopedic Institute Galeazzi Dental Clinic, Section of Implant Dentistry and Oral Rehabilitation  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziano","family":"Testori","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Department of Biomedical, Surgical and Dental Sciences Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"IRCCS Orthopedic Institute Galeazzi Dental Clinic, Section of Implant Dentistry and Oral Rehabilitation  Milan Italy"},{"name":"Department of Oral Medicine, Infection and Immunity Harvard University, School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-0984","authenticated-orcid":false,"given":"Massimo","family":"Del Fabbro","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"UOC 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