{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:02:27Z","timestamp":1792803747422,"version":"4.5.0"},"reference-count":97,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["Prin202254FLSB"],"award-info":[{"award-number":["Prin202254FLSB"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["PNRR\u2010POC\u20102023\u201012377354"],"award-info":[{"award-number":["PNRR\u2010POC\u20102023\u201012377354"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the adjunctive effects of systemic antibiotics (SA) on clinical and microbiological outcomes in the treatment of peri\u2010implant diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis were conducted following PRISMA guidelines and registered on PROSPERO (CRD420251059056). Randomized and non\u2010randomized clinical trials evaluating SA as adjuncts to non\u2010surgical treatment of peri\u2010implant mucositis (PM) and to non\u2010surgical or surgical therapy of peri\u2010implantitis (PI) were included. Rob2 and MINORS tools were used to assess the risk of bias of included articles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen studies were included in the qualitative analysis, of which only nine randomized clinical trials met the criteria for quantitative analysis. For PM treatment, SA did not significantly affect any assessed clinical outcomes (p&gt;0.05). For PI treatment, the meta\u2010analysis showed that, in both non\u2010surgical and surgical PI treatment, adjunctive SA resulted in a significant bleeding on probing reduction at 12 months (p=0.007) and a significant probing pocket depth reduction at 12 months (p=0.004). However, no significant improvements in marginal bone level (MBL) were observed. For antimicrobial outcomes, only 2 studies reported significant effects of metronidazole as an adjunct to treatment on reductions in P. gingivalis and T. forsythia up to 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SA do not provide additional clinical or microbiological benefits in the treatment of PM. In PI, adjunctive systemic antibiotics may offer only limited improvements in selected clinical outcomes and specific peri\u2010implant pathogens for up to 12 months, without consistent benefits on MBL. However, given the heterogeneity of the available evidence, further high\u2010quality, long\u2010term studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.70033","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:04:11Z","timestamp":1775106251000},"page":"284-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Impact and efficacy of systemic antibiotics for peri\u2010implant diseases treatment: A systematic review and meta\u2010analysis on clinical and microbiological outcomes"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-6992","authenticated-orcid":false,"given":"Gaetano","family":"Isola","sequence":"first","affiliation":[{"name":"Department of General Surgery and Medical\u2010Surgical Specialities, Unit of Periodontology University of Catania  Catania Italy"},{"name":"International Research Center on Periodontal and Systemic Health \u201cPerioHealth\u201d University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-8899","authenticated-orcid":false,"given":"Alessandro","family":"Polizzi","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical\u2010Surgical Specialities, Unit of Periodontology University of Catania  Catania Italy"},{"name":"International Research Center on Periodontal and Systemic Health \u201cPerioHealth\u201d University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3231-0704","authenticated-orcid":false,"given":"Angela","family":"Angjelova","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical\u2010Surgical Specialities, Unit of Periodontology University of Catania  Catania Italy"},{"name":"Faculty of Dentistry, Ss. Cyril and Methodius University in Skopje  Skopje North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1089-2598","authenticated-orcid":false,"given":"Elena","family":"Jovanova","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical\u2010Surgical Specialities, Unit of Periodontology University of Catania  Catania Italy"},{"name":"Faculty of Dentistry, Ss. Cyril and Methodius University in Skopje  Skopje North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-4924","authenticated-orcid":false,"given":"Giuseppe","family":"Pizzo","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Medical, Surgical and Critical Care (me.Pre.C.C.) University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5477","authenticated-orcid":false,"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000872"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516667484"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13823"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510186"},{"key":"e_1_2_11_8_1","first-page":"102","article-title":"A systematic review of biologic and technical complications with fixed implant rehabilitations for edentulous patients","volume":"27","author":"Papaspyridakos P","year":"2012","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01117.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01666.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-03058-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.56373\/2019-3-4"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-02020-1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41432-024-01071-x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.70021"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19116502"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13994"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13464"},{"issue":"81","key":"e_1_2_11_19_1","first-page":"124","article-title":"Soft tissue\u2010related complications and management around dental implants","volume":"2019","author":"Chackartchi T","year":"2000","journal-title":"Periodontol 2000"},{"issue":"79","key":"e_1_2_11_20_1","first-page":"15","article-title":"Nonsurgical therapy for teeth and implants\u2010when and why?","volume":"2019","author":"Lang NP","year":"2000","journal-title":"Periodontol 2000"},{"key":"e_1_2_11_21_1","first-page":"47","article-title":"Recombinant human platelet\u2010derived growth factor\u2010BB\u2010mediated reconstructive therapy of advanced peri\u2010implantitis bone defects: a case series","volume":"18","author":"Monje A","year":"2025","journal-title":"Int J Oral Implantol"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12160"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.14024"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14074"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12682"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.895537"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095142"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9020095"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12621"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12377"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04675-y"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513504950"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3947"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3182199348"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2276-y"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.02.009"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14782"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-011-0561-8"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.4161\/21505594.2014.980661"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12956"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.12.007"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01283.x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01274.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.134001"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.04.011"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12562"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13264"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60091393"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12150"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-01258-5"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213708"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0721"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12952"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13914"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2025.2595797"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14405"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2021.103790"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030402.x"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1498"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170362"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280106.x"},{"key":"e_1_2_11_62_1","first-page":"120","article-title":"Efficacy of systemic use of antibiotics as an adjunct to nonsurgical treatment of peri\u2010implantitis: a meta\u2010analysis of randomized controlled trials","volume":"55","author":"Luo R","year":"2024","journal-title":"Quintessence Int"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.70007"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13264"},{"key":"e_1_2_11_65_1","article-title":"Interventions for replacing missing teeth: treatment of peri\u2010implantitis","volume":"1","author":"Esposito M","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01837.x"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01674.x"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14080815"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13608"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12816"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2019.101587"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.101750"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-20-00259"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13564"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12813"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515601961"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12614"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12257"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01884.x"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12805"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02276.x"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6660052"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13429"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2019.vol33.0080"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2017.06.006"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13653"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13129"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12418"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g5.3"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01276.x"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13992"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13775"},{"key":"e_1_2_11_96_1","article-title":"The adjunctive use of systemic antibiotics in the non\u2010surgical and surgical treatment of peri\u2010implantitis: a systematic review and meta\u2010analysis","volume":"17","author":"Okuma\u2010Oliveira B","year":"2024","journal-title":"Int J Oral Implantol"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192315609"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"}],"container-title":["Periodontology 2000"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.70033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/prd.70033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.70033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:51:35Z","timestamp":1785559895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/prd.70033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":97,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/prd.70033"],"URL":"https:\/\/doi.org\/10.1111\/prd.70033","archive":["Portico"],"relation":{},"ISSN":["0906-6713","1600-0757"],"issn-type":[{"value":"0906-6713","type":"print"},{"value":"1600-0757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}