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Dental implants are an option for replacement of lost teeth in older adults. However, age\u2010related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This narrative review will focus on the age\u2010related changes that affect alveolar bone and the implications for periodontal disease and implant dentistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A literature search using the PubMed database was conducted. Search terms focused on the known age\u2010related pathological process affecting bone and involved in peri\u2010implant and periodontal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The literature demonstrates the multi\u2010faceted physiological changes that affect alveolar bone as a function of increased age. Osteoporosis is a commonly recognized feature of aging and studies support its association with periodontal disease as well as the growing body of work demonstrating the effects of osteoporosis on dental implant success. Furthermore, age\u2010related cellular perturbations have a detrimental impact on the strict inflammatory regulation that is required for bone homeostasis and during healing and regenerative processes. Finally, age\u2010related changes to osteoprogenitor cells likely contribute to pathology in the alveolar bone. However, multiple therapeutic targets have been identified to alter osteoprogenitor cell function for improvement of bone regeneration and homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Pathological changes that occur with age can be detrimental to alveolar bone, and an improved understanding of such changes can translate to future treatment modalities for the enhanced management of periodontal disease and dental implants in older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.70035","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:14:05Z","timestamp":1775722445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bone biology in aging periodontal and peri\u2010implant tissues"],"prefix":"10.1111","author":[{"given":"Dalia Rasheed","family":"Issa","sequence":"first","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"},{"name":"Center for Craniofacial Regeneration, University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Periodontology and Oral Medicine Kafrelsheikh University Faculty of Oral and Dental Medicine  Kafr El\u2010sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Intini","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"},{"name":"Center for Craniofacial Regeneration, University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"University of Pittsburgh UPMC Hillman Cancer Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"},{"name":"Center for Craniofacial Regeneration, University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2012.00148","article-title":"A new definition of aging?","volume":"3","author":"Flatt T","year":"2012","journal-title":"Front Genet"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2023.1115"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0745-x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12087"},{"issue":"11","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990\u20102010: a systematic review and meta\u2010regression","volume":"93","author":"Kassebaum N","year":"2014","journal-title":"J Dent Res"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140520"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom BL","year":"2005","journal-title":"Lancet"},{"key":"e_1_2_12_12_1","first-page":"1","article-title":"Prevalence of tooth loss among older adults: United States, 2015\u20102018","volume":"368","author":"Fleming E","year":"2020","journal-title":"NCHS Data Brief"},{"issue":"1","key":"e_1_2_12_13_1","first-page":"26","article-title":"Healing of femoral neck fractures; 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