{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:59:28Z","timestamp":1785290368984,"version":"3.55.0"},"reference-count":214,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent prevalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This opinion paper emphasizes the impact of systemic diseases on periodontal homeostasis and considers periodontal disease as a manifestation of systemic dysfunction rather than solely a bacterial local disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This paper is conceptually designed as a narrative review and synthesizes the molecular and cellular mechanisms through which systemic diseases converge to disrupt periodontal remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Emerging evidence underscores the critical role of systemic diseases, including chronic kidney disease, cardiovascular disease, liver dysfunction, and hematologic malignancies, in addition to studied uncontrolled diabetes mellitus, in destabilizing periodontal homeostasis. These systemic conditions are all associated with excess systemic inflammation that impairs regenerative capacity, mineralization, vascularity, and immune responses, fostering a subclinical environment prone to periodontal tissue pathologies with clinical impact. This opinion paper is conceptually designed as a narrative review and synthesizes the molecular and cellular mechanisms through which systemic diseases converge to disrupt periodontal remodeling, including periodontal pathologies as a consequence of systemic dysfunction rather than a purely bacterially induced local disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinically, this understanding demands intensified dental surveillance to uncover modifiers of susceptibility and interdisciplinary care for systemically compromised patients. Future research should identify early biomarkers of systemic impact and inform strategies that integrate oral and systemic health to reduce the periodontal disease burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.70048","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:36:44Z","timestamp":1785289004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5882-3080","authenticated-orcid":false,"given":"Michael","family":"Wolf","sequence":"first","affiliation":[{"name":"Department of Orthodontics RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Schulze\u2010Sp\u00e4te","sequence":"additional","affiliation":[{"name":"Section of Geriodontics, Department of Conservative Dentistry and Periodontology, Center of Dental Medicine University Hospital Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0568-124X","authenticated-orcid":false,"given":"Thomas","family":"Van Dyke","sequence":"additional","affiliation":[{"name":"Department of Inflammation and Immunology ADA Forsyth Institute  Somerville Massachusetts USA"},{"name":"Department of Oral Medicine, Infection and Immunity, Faculty of Medicine Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wolfart","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Biomaterials RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-7645","authenticated-orcid":false,"given":"Thomas","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Dentistry, School of Health Sciences, College of Medicine and Health, Birmingham Dental Hospital and School University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-9523","authenticated-orcid":false,"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Health Research Institute\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS\u2010FJD, UAM)  Madrid Spain"},{"name":"RICORS2040\u2010Renal  Madrid Spain"},{"name":"Departamento de Medicina, Facultad de Medicina Universidad Aut\u00f3noma de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojun","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-2967","authenticated-orcid":false,"given":"Joachim","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research RWTH Aachen University  Aachen Germany"},{"name":"Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM) University of Maastricht  Maastricht The Netherlands"},{"name":"AMCICARE RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"19919","DOI":"10.1038\/s41598-023-47386-0","article-title":"Periodontal ligament and alveolar bone remodeling during long orthodontic tooth movement analyzed by a novel user\u2010independent 3D\u2010methodology","volume":"13","author":"Rizk M","year":"2023","journal-title":"Sci Rep"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/prd.12368","article-title":"Maintaining homeostatic control of periodontal bone tissue","volume":"86","author":"Hathaway\u2010Schrader JD","year":"2021","journal-title":"Periodontology 2000"},{"issue":"1","key":"e_1_2_12_4_1","first-page":"S9","article-title":"Periodontal health","volume":"89","author":"Lang NP","year":"2018","journal-title":"J Periodontol"},{"key":"e_1_2_12_5_1","article-title":"Advancements in periodontal regeneration: a comprehensive review of stem cell therapy","volume":"16","author":"Bharuka T","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"12196","DOI":"10.3390\/cimb46110724","article-title":"Microbial dynamics in periodontal regeneration: understanding microbiome shifts and the role of antifouling and bactericidal materials: a narrative review","volume":"46","author":"Hashim NT","year":"2024","journal-title":"Curr Issues Mol Biol"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/jcm8081135","article-title":"Periodontitis: a multifaceted disease of tooth\u2010supporting tissues","volume":"8","author":"K\u00f6n\u00f6nen E","year":"2019","journal-title":"J Clin Med"},{"key":"e_1_2_12_8_1","first-page":"11","article-title":"Recent clinical treatment and basic research on the alveolar bone","volume":"11","author":"Tsuchida S","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/929486","article-title":"Management of internal root resorption on permanent teeth","volume":"2013","author":"Nilsson E","year":"2013","journal-title":"Int J Dent"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/idj.12317","article-title":"The association between oral hygiene and periodontitis: a systematic review and meta\u2010analysis","volume":"67","author":"Lertpimonchai A","year":"2017","journal-title":"Int Dent J"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/0022034517744556","article-title":"A force on the crown and tug of war in the periodontal complex","volume":"97","author":"Jang AT","year":"2018","journal-title":"J Dent Res"},{"issue":"16","key":"e_1_2_12_12_1","first-page":"S71","article-title":"Primary prevention of periodontitis: managing gingivitis","volume":"42","author":"Chapple IL","year":"2015","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1600-051X.2004.00563.x","article-title":"The long\u2010term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults. Results after 30\u2009years of maintenance","volume":"31","author":"Axelsson P","year":"2004","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/585048","article-title":"The effect of orthodontic therapy on periodontal health: a review of the literature","volume":"2014","author":"Alfuriji S","year":"2014","journal-title":"Int J Dent"},{"issue":"24","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13639","article-title":"Treatment of stage IV periodontitis: the EFP S3 level clinical practice guideline","volume":"49","author":"Herrera D","year":"2022","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/prd.12484","article-title":"Complications and treatment errors involving periodontal tissues related to orthodontic therapy","volume":"92","author":"Jepsen K","year":"2023","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_17_1","article-title":"Oral hygiene behavior and toothbrushing skills: results of the 6th German Oral health study (DMS \u2022 6)","volume":"56","author":"Deinzer R","year":"2025","journal-title":"Quintessence Int"},{"key":"e_1_2_12_18_1","article-title":"Prevalence of the periodontal status in Germany: results of the 6th German Oral health study (DMS \u2022 6)","volume":"56","author":"Eickholz P","year":"2025","journal-title":"Quintessence Int"},{"key":"e_1_2_12_19_1","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2146160","article-title":"Global prevalence of periodontal disease and lack of its surveillance","volume":"2020","author":"Nazir M","year":"2020","journal-title":"Sci World J"},{"key":"e_1_2_12_20_1","volume-title":"Periodontal Disease","author":"Gasner NS","year":"2025"},{"key":"e_1_2_12_21_1","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2019.vol33.0069","article-title":"Does traumatic occlusal forces lead to peri\u2010implant bone loss? A systematic review","volume":"33","author":"Bertolini MM","year":"2019","journal-title":"Braz Oral Res"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis G","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"e_1_2_12_23_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/prd.12160","article-title":"Bacterial modulators of bone remodeling in the periodontal pocket","volume":"76","author":"Henderson B","year":"2018","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_24_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.709438","article-title":"Periodontal inflammation and systemic diseases: an overview","volume":"12","author":"Mart\u00ednez\u2010Garc\u00eda M","year":"2021","journal-title":"Front Physiol"},{"key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/prd.12169","article-title":"Host modulation: controlling the inflammation to control the infection","volume":"75","author":"Bartold PM","year":"2017","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10266-006-0060-6","article-title":"Periodontal disease and systemic conditions: a bidirectional relationship","volume":"94","author":"Kim J","year":"2006","journal-title":"Odontology"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1875-595X.1998.tb00711.x","article-title":"Periodontal disease and tooth loss","volume":"48","author":"Ong G","year":"1998","journal-title":"Int Dent J"},{"key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1600-051X.2011.01733.x","article-title":"Tooth loss in aggressive periodontitis after active periodontal therapy: patient\u2010related and tooth\u2010related prognostic factors","volume":"38","author":"B\u00e4umer A","year":"2011","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-0757.1993.tb00224.x","article-title":"Periodontal diseases and tooth loss","volume":"2","author":"Oliver RC","year":"1993","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_30_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/prd.12318","article-title":"The impact of diabetes on periodontal diseases","volume":"82","author":"Graves DT","year":"2020","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/prd.12232","article-title":"Genetics of periodontitis: discovery, biology, and clinical impact","volume":"78","author":"Schaefer AS","year":"2018","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_32_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20021298","article-title":"Chronic kidney disease and periodontitis interplay\u2010a narrative review","volume":"20","author":"Baciu SF","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"e_1_2_12_33_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41581-024-00910-5","article-title":"Interplay between periodontitis and chronic kidney disease","volume":"21","author":"Chapple ILC","year":"2025","journal-title":"Nat Rev Nephrol"},{"key":"e_1_2_12_34_1","first-page":"S104","article-title":"Cardiovascular diseases and oral health: results of the 6th German oral health study (DMS \u2022 6)","volume":"56","author":"Jordan AR","year":"2025","journal-title":"Quintessence Int"},{"key":"e_1_2_12_35_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: consensus report","volume":"47","author":"Sanz M","year":"2020","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_36_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ehf2.12126","article-title":"Periodontitis and bone metabolism in patients with advanced heart failure and after heart transplantation","volume":"4","author":"Schulze\u2010Sp\u00e4te U","year":"2017","journal-title":"ESC Heart Fail"},{"key":"e_1_2_12_37_1","article-title":"Role of nonalcoholic fatty liver disease in periodontitis: a bidirectional relationship","volume":"16","author":"Vegda HS","year":"2024","journal-title":"Cureus"},{"issue":"89","key":"e_1_2_12_38_1","first-page":"125","article-title":"Periodontitis, chronic liver diseases, and the emerging oral\u2010gut\u2010liver axis","volume":"2022","author":"Albuquerque\u2010Souza E","year":"2000","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_39_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/ijms25116115","article-title":"Grywalska E and Rahnama\u2010Hezavah M. The bloody crossroads: interactions between periodontitis and hematologic diseases","volume":"25","author":"\u0141obacz M","year":"2024","journal-title":"Int J Mol Sci"},{"key":"e_1_2_12_40_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrrheum.2017.132","article-title":"The case for periodontitis in the pathogenesis of rheumatoid arthritis","volume":"13","author":"Potempa J","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"e_1_2_12_41_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/jcpe.12698","article-title":"Inflammatory bowel disease and oral health: systematic review and a meta\u2010analysis","volume":"44","author":"Papageorgiou SN","year":"2017","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_42_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/0022034518805739","article-title":"The Oral microbiota is modified by systemic diseases","volume":"98","author":"Graves DT","year":"2019","journal-title":"J Dent Res"},{"key":"e_1_2_12_43_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/prd.12331","article-title":"Current understanding of periodontal disease pathogenesis and targets for host\u2010modulation therapy","volume":"84","author":"Hajishengallis G","year":"2020","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_44_1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis G","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"e_1_2_12_45_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12616","article-title":"Periodontal disease: a systemic condition","volume":"96","author":"Villoria GEM","year":"2024","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_46_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCRESAHA.119.311148","article-title":"The extracellular matrix in ischemic and nonischemic heart failure","volume":"125","author":"Frangogiannis NG","year":"2019","journal-title":"Circ Res"},{"key":"e_1_2_12_47_1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.kint.2017.06.030","article-title":"AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms","volume":"92","author":"He L","year":"2017","journal-title":"Kidney Int"},{"key":"e_1_2_12_48_1","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1902\/jop.2015.150195","article-title":"Association between periodontal disease and kidney function decline in African Americans: the Jackson heart study","volume":"86","author":"Grubbs V","year":"2015","journal-title":"J Periodontol"},{"key":"e_1_2_12_49_1","doi-asserted-by":"crossref","DOI":"10.1177\/2050312115601122","article-title":"Periodontal disease and liver cirrhosis: a systematic review","volume":"3","author":"Gr\u00f8nkj\u00e6r LL","year":"2015","journal-title":"SAGE Open Med"},{"key":"e_1_2_12_50_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165601","article-title":"Risk of atrial fibrillation or flutter associated with periodontitis: a Nationwide, population\u2010based, cohort study","volume":"11","author":"Chen DY","year":"2016","journal-title":"PLoS One"},{"key":"e_1_2_12_51_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpc.2021.100179","article-title":"Oral health and atherosclerotic cardiovascular disease: a review","volume":"7","author":"Gianos E","year":"2021","journal-title":"Am J Prev Cardiol"},{"key":"e_1_2_12_52_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.amjmed.2023.11.022","article-title":"Oral health and cardiovascular disease","volume":"137","author":"Hopkins S","year":"2024","journal-title":"Am J Med"},{"key":"e_1_2_12_53_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/toxins15110666","article-title":"Association between dental scores and saliva uremic toxins","volume":"15","author":"Rigothier C","year":"2023","journal-title":"Toxins (Basel)"},{"key":"e_1_2_12_54_1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/jcpe.13172","article-title":"Periodontitis in individuals with liver cirrhosis: a case\u2010control study","volume":"46","author":"Costa FO","year":"2019","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_55_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/prd.12322","article-title":"Epigenetic reprogramming in periodontal disease: dynamic crosstalk with potential impact in oncogenesis","volume":"82","author":"Barros SP","year":"2020","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_56_1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/jre.12477","article-title":"The intricate anatomy of the periodontal ligament and its development: lessons for periodontal regeneration","volume":"52","author":"Jong T","year":"2017","journal-title":"J Periodontal Res"},{"key":"e_1_2_12_57_1","article-title":"Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement","author":"Parisi L","year":"2024","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_58_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41368-025-00354-y","article-title":"Exploring the mechanical and biological interplay in the periodontal ligament","volume":"17","author":"Wen X","year":"2025","journal-title":"Int J Oral Sci"},{"key":"e_1_2_12_59_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/(SICI)1097-0185(199606)245:2<327::AID-AR15>3.0.CO;2-R","article-title":"Periodontal ligament cell population: the central role of fibroblasts in creating a unique tissue","volume":"245","author":"Lekic P","year":"1996","journal-title":"Anat Rec"},{"key":"e_1_2_12_60_1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/prd.12515","article-title":"Control of tissue homeostasis by the extracellular matrix: synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration","volume":"94","author":"Miguez PA","year":"2024","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_61_1","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.23490","article-title":"Roles of osteoclasts in alveolar bone remodeling","volume":"60","author":"Omi M","year":"2022","journal-title":"Genesis"},{"key":"e_1_2_12_62_1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1080\/08977190601060990","article-title":"Role of growth factors on periodontal repair","volume":"24","author":"Dereka XE","year":"2006","journal-title":"Growth Factors"},{"key":"e_1_2_12_63_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2\u2010catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu J","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_2_12_64_1","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.204","article-title":"Double\u2010edged\u2010sword effect of IL\u20101\u03b2 on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF\u2010\u03baB, MAPK and BMP\/Smad signaling pathways","volume":"7","author":"Mao CY","year":"2016","journal-title":"Cell Death Dis"},{"key":"e_1_2_12_65_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052763","article-title":"Matrix metalloproteinases in the periodontium\u2010vital in tissue turnover and unfortunate in periodontitis","volume":"25","author":"Radzki D","year":"2024","journal-title":"Int J Mol Sci"},{"key":"e_1_2_12_66_1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/jcpe.13751","article-title":"Mediterranean diet component oleic acid increases protective lipid mediators and improves trabecular bone in a Porphyromonas gingivalis inoculation model","volume":"50","author":"Doding A","year":"2023","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_67_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1213026","article-title":"Immunometabolic capacities of nutritional fatty acids in regulation of inflammatory bone cell interaction and systemic impact of periodontal infection","volume":"14","author":"Doding A","year":"2023","journal-title":"Front Immunol"},{"key":"e_1_2_12_68_1","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1172\/JCI97951","article-title":"Key roles for lipid mediators in the adaptive immune response","volume":"128","author":"Duffney PF","year":"2018","journal-title":"J Clin Invest"},{"key":"e_1_2_12_69_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.01307","article-title":"Distinct profiles of specialized pro\u2010resolving lipid mediators and corresponding receptor gene expression in periodontal inflammation","volume":"11","author":"Ferguson B","year":"2020","journal-title":"Front Immunol"},{"key":"e_1_2_12_70_1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1038\/s41467-022-30374-9","article-title":"PI(18:1\/18:1) is a SCD1\u2010derived lipokine that limits stress signaling","volume":"13","author":"Thurmer M","year":"2022","journal-title":"Nat Commun"},{"key":"e_1_2_12_71_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41514-025-00248-7","article-title":"Mediterranean diet component oleic acid decreases systemic impact of periodontal Porphyromonas gingivalis\u2010infection in age: addressing role of stress resistance and microbiome","volume":"11","author":"Doding A","year":"2025","journal-title":"NPJ Aging"},{"key":"e_1_2_12_72_1","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/bjp.2008.367","article-title":"An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption","volume":"155","author":"Herrera BS","year":"2008","journal-title":"Br J Pharmacol"},{"key":"e_1_2_12_73_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043158","article-title":"Regulation of the host immune microenvironment in periodontitis and periodontal bone remodeling","volume":"24","author":"Han N","year":"2023","journal-title":"Int J Mol Sci"},{"key":"e_1_2_12_74_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/0022034513511640","article-title":"Cooperative effects of FGF\u20102 and VEGF\u2010A in periodontal ligament cells","volume":"93","author":"Yanagita M","year":"2014","journal-title":"J Dent Res"},{"key":"e_1_2_12_75_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-3-030-11093-2_10","article-title":"Pericytes in the periodontal ligament","volume":"1122","author":"Komaki M","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_12_76_1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/JPER.23-0458","article-title":"Enhanced periodontal tissue healing via vascular endothelial growth factor expression following low\u2010level erbium\u2010doped: yttrium, aluminum, and garnet laser irradiation: in\u00a0vitro and in\u00a0vivo studies","volume":"95","author":"Takemura S","year":"2024","journal-title":"J Periodontol"},{"key":"e_1_2_12_77_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo BM","year":"2004","journal-title":"Lancet"},{"key":"e_1_2_12_78_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076353","article-title":"Dental follicle stem cells promote periodontal regeneration through Periostin\u2010mediated macrophage infiltration and reprogramming in an inflammatory microenvironment","volume":"24","author":"Wei X","year":"2023","journal-title":"Int J Mol Sci"},{"key":"e_1_2_12_79_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.14348\/molcells.2017.0019","article-title":"Effect of FGF\u20102, TGF\u2010\u03b2\u20101, and BMPs on Teno\/Ligamentogenesis and osteo\/Cementogenesis of human periodontal ligament stem cells","volume":"40","author":"Hyun SY","year":"2017","journal-title":"Mol Cells"},{"key":"e_1_2_12_80_1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1089\/ten.tea.2013.0512","article-title":"Stem cells derived from tooth periodontal ligament enhance functional angiogenesis by endothelial cells","volume":"20","author":"Yeasmin S","year":"2014","journal-title":"Tissue Eng Part A"},{"key":"e_1_2_12_81_1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/JPER.24-0070","article-title":"Angiogenic potential in periodontal stem cells from upper and lower jaw: a pilot study","volume":"95","author":"Malyaran H","year":"2024","journal-title":"J Periodontol"},{"key":"e_1_2_12_82_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3353\/omp.3.1","article-title":"Homeostasis and regeneration of the periodontal ligament","volume":"3","author":"Shimono M","year":"1998","journal-title":"Oral Med Pathol"},{"key":"e_1_2_12_83_1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1902\/jop.2016.150475","article-title":"Increased periodontal attachment loss in patients with systemic sclerosis","volume":"87","author":"Pischon N","year":"2016","journal-title":"J Periodontol"},{"key":"e_1_2_12_84_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1600-051X.2011.01814.x","article-title":"The impact of dietary induced hyperparathyroidism on healthy and diseased periodontia: an experimental study in rats","volume":"39","author":"L\u00fctfio\u011flu M","year":"2012","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_85_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1159\/000356335","article-title":"Adverse mandibular bone effects associated with kidney disease are only partially corrected with bisphosphonate and\/or calcium treatment","volume":"38","author":"Allen MR","year":"2013","journal-title":"Am J Nephrol"},{"key":"e_1_2_12_86_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4103\/0970-9290.114917","article-title":"Multiple internal resorption in permanent teeth associated with hyperparathyroidism","volume":"24","author":"Nagaraj E","year":"2013","journal-title":"Indian J Dent Res"},{"key":"e_1_2_12_87_1","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.joen.2013.12.030","article-title":"Root resorption caused by jaw infiltration of multiple myeloma: report of a case and literature review","volume":"40","author":"Troeltzsch M","year":"2014","journal-title":"J Endod"},{"key":"e_1_2_12_88_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/odi.12708","article-title":"Risk factors for medication\u2010related osteonecrosis of the jaws: a systematic review","volume":"24","author":"McGowan K","year":"2018","journal-title":"Oral Dis"},{"key":"e_1_2_12_89_1","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/odi.13046","article-title":"Systemic comorbidities are associated with medication\u2010related osteonecrosis of the jaws: case\u2010control study","volume":"25","author":"McGowan K","year":"2019","journal-title":"Oral Dis"},{"key":"e_1_2_12_90_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1902\/jop.1978.49.12.607","article-title":"The natural history of periodontal disease in man. The rate of periodontal destruction before 40\u2009years of age","volume":"49","author":"L\u00f6e H","year":"1978","journal-title":"J Periodontol"},{"key":"e_1_2_12_91_1","first-page":"235","article-title":"Pathogenesis of inflammatory periodontal disease. A summary of current work","volume":"34","author":"Page RC","year":"1976","journal-title":"Lab Invest"},{"key":"e_1_2_12_92_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1600-051X.1981.tb02039.x","article-title":"The significance of maintenance care in the treatment of periodontal disease","volume":"8","author":"Axelsson P","year":"1981","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_93_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-051X.1975.tb01727.x","article-title":"The effect of plaque control and surgical pocket elimination on the establishment and maintenance of periodontal health. A longitudinal study of periodontal therapy in cases of advanced disease","volume":"2","author":"Lindhe J","year":"1975","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_94_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1600-051X.1987.tb02249.x","article-title":"4 modalities of periodontal treatment compared over 5\u2009years","volume":"14","author":"Ramfjord SP","year":"1987","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_95_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1902\/annals.1996.1.1.443","article-title":"Non\u2010surgical pocket therapy: mechanical","volume":"1","author":"Cobb CM","year":"1996","journal-title":"Ann Periodontol"},{"key":"e_1_2_12_96_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage GC","year":"1999","journal-title":"Ann Periodontol"},{"issue":"11","key":"e_1_2_12_97_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-051X.2010.01675.x","article-title":"Biological approaches to the development of novel periodontal therapies\u2013consensus of the seventh European workshop on periodontology","volume":"38","author":"Tonetti MS","year":"2011","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_98_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0757.2004.03797.x","article-title":"How effective is surgical therapy compared with nonsurgical debridement?","volume":"37","author":"Heitz\u2010Mayfield LJ","year":"2005","journal-title":"Periodontol 2000"},{"issue":"1","key":"e_1_2_12_99_1","first-page":"S173","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri\u2010implant diseases and conditions","volume":"89","author":"Papapanou PN","year":"2018","journal-title":"J Periodontol"},{"key":"e_1_2_12_100_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-0757.2012.00450.x","article-title":"Periodontitis: a host\u2010mediated disruption of microbial homeostasis. Unlearning learned concepts","volume":"62","author":"Bartold PM","year":"2013","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_101_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-0757.2011.00414.x","article-title":"Causal theory and the etiology of periodontal diseases","volume":"58","author":"Heaton B","year":"2012","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_102_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3122\/jabfm.2022.220207R1","article-title":"The prevalence of periodontitis among US adults with multimorbidity using NHANES data 2011\u20102014","volume":"36","author":"O'Dwyer MC","year":"2023","journal-title":"J Am Board Fam Med"},{"issue":"22","key":"e_1_2_12_103_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13290","article-title":"Treatment of stage I\u2010III periodontitis\u2010the EFP S3 level clinical practice guideline","volume":"47","author":"Sanz M","year":"2020","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_104_1","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/0022034512457373","article-title":"Prevalence of periodontitis in adults in the United States: 2009 and 2010","volume":"91","author":"Eke PI","year":"2012","journal-title":"J Dent Res"},{"key":"e_1_2_12_105_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1902\/jop.2015.140520","article-title":"Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012","volume":"86","author":"Eke PI","year":"2015","journal-title":"J Periodontol"},{"key":"e_1_2_12_106_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-0757.2011.00425.x","article-title":"The global burden of periodontal disease: towards integration with chronic disease prevention and control","volume":"60","author":"Petersen PE","year":"2012","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_107_1","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1902\/jop.2007.060264","article-title":"Case definitions for use in population\u2010based surveillance of periodontitis","volume":"78","author":"Page RC","year":"2007","journal-title":"J Periodontol"},{"key":"e_1_2_12_108_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/prd.12251","article-title":"Role of occlusion in periodontal disease","volume":"79","author":"Passanezi E","year":"2019","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_109_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/jcpe.12808","article-title":"Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the international diabetes federation and the European Federation of Periodontology","volume":"45","author":"Sanz M","year":"2018","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_110_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3389\/fimmu.2020.00511","article-title":"The nexus between periodontal inflammation and dysbiosis","volume":"11","author":"Van Dyke TE","year":"2020","journal-title":"Front Immunol"},{"key":"e_1_2_12_111_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: dual anti\u2010inflammatory and pro\u2010resolution lipid mediators","volume":"8","author":"Serhan CN","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"e_1_2_12_112_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10555-023-10091-5","article-title":"Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next pandemic?","volume":"42","author":"Serhan CN","year":"2023","journal-title":"Cancer Metastasis Rev"},{"key":"e_1_2_12_113_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1469077","article-title":"Crosstalk between periodontitis and cardiovascular risk","volume":"15","author":"Schulze\u2010Sp\u00e4te U","year":"2024","journal-title":"Front Immunol"},{"key":"e_1_2_12_114_1","first-page":"211","article-title":"Bidirectional relationship between Chronic Kidney Disease & Periodontal Disease","volume":"29","author":"Wahid A","year":"2013","journal-title":"Pak J Med Sci"},{"key":"e_1_2_12_115_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.etp.2014.01.003","article-title":"Uremic toxins impair human bone marrow\u2010derived mesenchymal stem cells functionality in\u00a0vitro","volume":"66","author":"Idziak M","year":"2014","journal-title":"Exp Toxicol Pathol"},{"key":"e_1_2_12_116_1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/prd.12457","article-title":"Inflammation as a link between periodontal disease and obesity","volume":"90","author":"Pamuk F","year":"2022","journal-title":"Periodontol 2000"},{"issue":"4","key":"e_1_2_12_117_1","first-page":"544","article-title":"Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells","volume":"2024","author":"Chansaenroj J","year":"2021","journal-title":"Med Rev"},{"key":"e_1_2_12_118_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1186\/s13287-022-03225-z","article-title":"Strategies of cell and cell\u2010free therapies for periodontal regeneration: the state of the art","volume":"13","author":"Wang X","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"e_1_2_12_119_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1438726","article-title":"Mechanisms of mechanical force in periodontal homeostasis: a review","volume":"15","author":"Wang T","year":"2024","journal-title":"Front Immunol"},{"key":"e_1_2_12_120_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s40496-014-0044-5","article-title":"The biofilm community\u2010rebels with a cause","volume":"2","author":"Aruni AW","year":"2015","journal-title":"Curr Oral Health Rep"},{"key":"e_1_2_12_121_1","first-page":"11","article-title":"The role and involvement of stem cells in periodontology","volume":"11","author":"Goriuc A","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_12_122_1","article-title":"Effect of aging on homeostasis in the soft tissue of the periodontium: a narrative review","volume":"11","author":"Kim YG","year":"2021","journal-title":"J Pers Med"},{"key":"e_1_2_12_123_1","article-title":"The effect of periodontitis on fibroblast growth factor 23 levels in Predialysis chronic kidney disease patients","volume":"16","author":"Wan Abdul Azim WA","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_12_124_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12882-015-0068-7","article-title":"Association of C\u2010reactive protein, tumor necrosis factor\u2010alpha, and interleukin\u20106 with chronic kidney disease","volume":"16","author":"Lee BT","year":"2015","journal-title":"BMC Nephrol"},{"key":"e_1_2_12_125_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.910592","article-title":"Mesenchymal stem cells: a new therapeutic tool for chronic kidney disease","volume":"10","author":"Wang J","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"e_1_2_12_126_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010263","article-title":"Inflammation and oxidative stress in chronic kidney disease\u2010potential therapeutic role of minerals, vitamins and plant\u2010derived metabolites","volume":"21","author":"Rapa SF","year":"2019","journal-title":"Int J Mol Sci"},{"key":"e_1_2_12_127_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02845","article-title":"Chronic kidney disease severity is associated with selective expansion of a distinctive intermediate monocyte subpopulation","volume":"9","author":"Naicker SD","year":"2018","journal-title":"Front Immunol"},{"key":"e_1_2_12_128_1","article-title":"Vitamin D Deficiency, chronic kidney disease and periodontitis","volume":"60","author":"Ganimusa I","year":"2024","journal-title":"Medicina (Kaunas)"},{"key":"e_1_2_12_129_1","doi-asserted-by":"crossref","DOI":"10.3390\/dj13030098","article-title":"Unveiling the molecular crosstalk between periodontal and cardiovascular diseases: a systematic review","volume":"13","author":"Dhungana G","year":"2025","journal-title":"Dent J (Basel)"},{"key":"e_1_2_12_130_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western Diet Triggers NLRP3\u2010Dependent Innate Immune Reprogramming","volume":"172","author":"Christ A","year":"2018","journal-title":"Cell"},{"key":"e_1_2_12_131_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/00220345251369518","article-title":"Fighting age\u2010associated bone loss in periodontitis with dietary interventions","volume":"105","author":"D\u00f6ding A","year":"2026","journal-title":"J Dent Res"},{"key":"e_1_2_12_132_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.coi.2011.05.007","article-title":"Inflammation and mesenchymal stem cell aging","volume":"23","author":"Lepperdinger G","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"e_1_2_12_133_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s41100-024-00581-9","article-title":"Dysbiosis of oral bacteria in patients with chronic kidney disease","volume":"10","author":"Yasuno T","year":"2024","journal-title":"Renal Replace Ther"},{"key":"e_1_2_12_134_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12903-020-1015-y","article-title":"Annual alveolar bone loss in subjects with cardiovascular disease adjusting for associated systemic diseases and risk factors: a retrospective study","volume":"20","author":"Helmi M","year":"2020","journal-title":"BMC Oral Health"},{"key":"e_1_2_12_135_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15644\/asc50\/1\/4","article-title":"Evaluation of periodontal parameters in patients with early stage chronic lymphocytic leukemia","volume":"50","author":"Rin\u010di\u0107 N","year":"2016","journal-title":"Acta Stomatol Croat"},{"key":"e_1_2_12_136_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/(SICI)1097-0185(199801)250:1<13::AID-AR3>3.0.CO;2-F","article-title":"Developmental appearance and distribution of bone sialoprotein and osteopontin in human and rat cementum","volume":"250","author":"Bosshardt DD","year":"1998","journal-title":"Anat Rec"},{"key":"e_1_2_12_137_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/ph14040289","article-title":"Matrix vesicles: role in bone mineralization and potential use as therapeutics","volume":"14","author":"Ansari S","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"e_1_2_12_138_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","article-title":"Mechanical regulation of bone remodeling","volume":"10","author":"Wang L","year":"2022","journal-title":"Bone Res"},{"key":"e_1_2_12_139_1","article-title":"Secondary hyperparathyroidism in chronic kidney disease: pathophysiology and management","volume":"13","author":"Habas E","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_12_140_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1034\/j.1600-051X.2002.290601.x","article-title":"The effect of secondary hyperparathyroidism and hemodialysis therapy on alveolar bone and periodontium","volume":"29","author":"Frankenthal S","year":"2002","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_141_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/ijos.2015.1","article-title":"Fibroblast growth factor 23 and bone mineralisation","volume":"7","author":"Guo Y\u2010C","year":"2015","journal-title":"Int J Oral Sci"},{"key":"e_1_2_12_142_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.759056","article-title":"Assessment of alveolar bone and periodontal status in peritoneal dialysis patients","volume":"12","author":"Sun K","year":"2021","journal-title":"Front Physiol"},{"key":"e_1_2_12_143_1","first-page":"11","article-title":"The potential influence of uremic toxins on the homeostasis of bones and muscles in chronic kidney disease","volume":"11","author":"Hung KC","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_12_144_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jot.2024.07.008","article-title":"Emerging role of liver\u2010bone axis in osteoporosis","volume":"48","author":"Gao H","year":"2024","journal-title":"J Orthop Translat"},{"key":"e_1_2_12_145_1","doi-asserted-by":"crossref","first-page":"i15","DOI":"10.1093\/ckj\/sfae423","article-title":"Pathophysiology and therapies of CKD\u2010associated secondary hyperparathyroidism","volume":"18","author":"Mazzaferro S","year":"2025","journal-title":"Clin Kidney J"},{"key":"e_1_2_12_146_1","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1093\/ndt\/gfr591","article-title":"The connections between vascular calcification and bone health","volume":"26","author":"Cannata\u2010Andia JB","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_12_147_1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1902\/jop.2007.060433","article-title":"Mechanical stress induces osteopontin expression in human periodontal ligament cells through rho kinase","volume":"78","author":"Wongkhantee S","year":"2007","journal-title":"J Periodontol"},{"key":"e_1_2_12_148_1","doi-asserted-by":"crossref","DOI":"10.31083\/j.fbl2702054","article-title":"MAPK and \u03b2\u2010catenin signaling: implication and interplay in orthodontic tooth movement","volume":"27","author":"Yong J","year":"2022","journal-title":"Front Biosci (Landmark Ed)"},{"key":"e_1_2_12_149_1","article-title":"Periodontal response to nonsurgical accelerated orthodontic tooth movement","author":"Oner F","year":"2025","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_150_1","first-page":"7872","article-title":"Cyclic tension promotes osteogenic differentiation in human periodontal ligament stem cells","volume":"7","author":"Shen T","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_12_151_1","first-page":"9","article-title":"Vascular calcification in chronic kidney disease: diversity in the Vessel Wall","volume":"9","author":"Dube P","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_12_152_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mam.2004.09.003","article-title":"The role of nitric oxide in cardiovascular diseases","volume":"26","author":"Naseem KM","year":"2005","journal-title":"Mol Aspects Med"},{"key":"e_1_2_12_153_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/jor.20515","article-title":"Stimulation of nitric oxide mechanotransduction in single osteoblasts using atomic force microscopy","volume":"26","author":"McGarry JG","year":"2008","journal-title":"J Orthop Res"},{"key":"e_1_2_12_154_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.identj.2024.12.001","article-title":"Effect of mechanical force stress on the inflammatory response in human periodontal ligament cells","volume":"75","author":"Rojasawasthien T","year":"2025","journal-title":"Int Dent J"},{"key":"e_1_2_12_155_1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont RJ","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"e_1_2_12_156_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/odi.12509","article-title":"A practical guide to the oral microbiome and its relation to health and disease","volume":"23","author":"Krishnan K","year":"2017","journal-title":"Oral Dis"},{"key":"e_1_2_12_157_1","first-page":"87","article-title":"Dental plaque biofilm in oral health and disease","volume":"14","author":"Seneviratne CJ","year":"2011","journal-title":"Chin J Dent Res"},{"key":"e_1_2_12_158_1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/mi.2015.136","article-title":"Characterization of the human immune cell network at the gingival barrier","volume":"9","author":"Dutzan N","year":"2016","journal-title":"Mucosal Immunol"},{"key":"e_1_2_12_159_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.it.2017.08.005","article-title":"Tissue\u2010specific immunity at the Oral mucosal barrier","volume":"39","author":"Moutsopoulos NM","year":"2018","journal-title":"Trends Immunol"},{"key":"e_1_2_12_160_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/prd.12181","article-title":"Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40\u2009years later","volume":"75","author":"Hajishengallis G","year":"2017","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_161_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.bbalip.2014.09.002","article-title":"Transcellular biosynthesis of eicosanoid lipid mediators","volume":"1851","author":"Capra V","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_12_162_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin D","year":"2010","journal-title":"Nat Immunol"},{"key":"e_1_2_12_163_1","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v2i0.5532","article-title":"Role of periodontal pathogenic bacteria in RANKL\u2010mediated bone destruction in periodontal disease","volume":"2","author":"Kajiya M","year":"2010","journal-title":"J Oral Microbiol"},{"key":"e_1_2_12_164_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nature01096","article-title":"Production and detection of cold antihydrogen atoms","volume":"419","author":"Amoretti M","year":"2002","journal-title":"Nature"},{"key":"e_1_2_12_165_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1046\/j.1525-139X.2002.00084.x","article-title":"Biofilms and infection in dialysis patients","volume":"15","author":"Dasgupta MK","year":"2002","journal-title":"Semin Dial"},{"key":"e_1_2_12_166_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1053\/j.ackd.2006.04.002","article-title":"Biofilm: its relevance in kidney disease","volume":"13","author":"Tapia G","year":"2006","journal-title":"Adv Chronic Kidney Dis"},{"key":"e_1_2_12_167_1","doi-asserted-by":"crossref","DOI":"10.1111\/apha.70057","article-title":"Neutrophil function in patients with chronic kidney disease: a systematic review and meta\u2010analysis","volume":"241","author":"Lauxen JS","year":"2025","journal-title":"Acta Physiol (Oxf)"},{"key":"e_1_2_12_168_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/omi.12321","article-title":"Periodontal pathogens' strategies disarm neutrophils to promote dysregulated inflammation","volume":"36","author":"Miralda I","year":"2021","journal-title":"Mol Oral Microbiol"},{"key":"e_1_2_12_169_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.822190","article-title":"Oral and gut microbial dysbiosis and non\u2010alcoholic fatty liver disease: the central role of Porphyromonas gingivalis","volume":"9","author":"Wang T","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"e_1_2_12_170_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1010368","article-title":"The oral microbiota and cardiometabolic health: a comprehensive review and emerging insights","volume":"13","author":"Li Y","year":"2022","journal-title":"Front Immunol"},{"key":"e_1_2_12_171_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in\u00a0vivo","volume":"209","author":"Br\u00fchl ML","year":"2012","journal-title":"J Exp Med"},{"key":"e_1_2_12_172_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020559","article-title":"Neutrophil extracellular traps and their implications in cardiovascular and inflammatory disease","volume":"22","author":"Klopf J","year":"2021","journal-title":"Int J Mol Sci"},{"key":"e_1_2_12_173_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/jcm13020468","article-title":"Extracellular DNA and markers of neutrophil extracellular traps in saliva from patients with periodontitis\u2010a case\u2010control study","volume":"13","author":"Kovalcikova AG","year":"2024","journal-title":"J Clin Med"},{"key":"e_1_2_12_174_1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/jcpe.12628","article-title":"Peripheral blood neutrophil extracellular trap production and degradation in chronic periodontitis","volume":"43","author":"White P","year":"2016","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_175_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/1753425919889392","article-title":"Periodontal therapy increases neutrophil extracellular trap degradation","volume":"26","author":"Moonen CG","year":"2020","journal-title":"Innate Immun"},{"key":"e_1_2_12_176_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nm.3589","article-title":"Chronic variable stress activates hematopoietic stem cells","volume":"20","author":"Heidt T","year":"2014","journal-title":"Nat Med"},{"key":"e_1_2_12_177_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/prd.12380","article-title":"Frailty, aging, and periodontal disease: basic biologic considerations","volume":"87","author":"Clark D","year":"2021","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_178_1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/s41591-023-02296-6","article-title":"Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality","volume":"29","author":"Tian YE","year":"2023","journal-title":"Nat Med"},{"key":"e_1_2_12_179_1","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.03281-20","article-title":"Longitudinal multi\u2010omics and microbiome meta\u2010analysis identify an asymptomatic gingival state that links gingivitis, periodontitis, and aging","volume":"12","author":"Huang S","year":"2021","journal-title":"MBio"},{"key":"e_1_2_12_180_1","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1016\/j.cell.2025.07.030","article-title":"Systematic profiling reveals betaine as an exercise mimetic for geroprotection","volume":"188","author":"Geng L","year":"2025","journal-title":"Cell"},{"key":"e_1_2_12_181_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro\u2010o M","year":"1997","journal-title":"Nature"},{"key":"e_1_2_12_182_1","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1093\/ndt\/gfx376","article-title":"Albumin downregulates klotho in tubular cells","volume":"33","author":"Fernandez\u2010Fernandez B","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_12_183_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1369\/0022155416689670","article-title":"Histochemical examination on periodontal tissues of klotho\u2010deficient mice fed with phosphate\u2010insufficient diet","volume":"65","author":"Hikone K","year":"2017","journal-title":"J Histochem Cytochem"},{"key":"e_1_2_12_184_1","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1111\/odi.15402","article-title":"Clinical applications and mechanisms of klotho in periodontitis diagnosis and therapy","volume":"31","author":"Wan C","year":"2025","journal-title":"Oral Dis"},{"key":"e_1_2_12_185_1","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1038\/s41598-023-33521-4","article-title":"Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis","volume":"13","author":"Rodriguez\u2010Agurto A","year":"2023","journal-title":"Sci Rep"},{"key":"e_1_2_12_186_1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.7150\/ijms.48492","article-title":"P\u2010cresol and indoxyl sulfate impair osteogenic differentiation by triggering mesenchymal stem cell senescence","volume":"18","author":"Kamprom W","year":"2021","journal-title":"Int J Med Sci"},{"key":"e_1_2_12_187_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/tcmj.tcmj_212_23","article-title":"The influence of uremic toxins on low bone turnover disease in chronic kidney disease","volume":"36","author":"Yiang G\u2010T","year":"2024","journal-title":"Tzu chi Medical Journal"},{"key":"e_1_2_12_188_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2023.12.009","article-title":"Stem cell\u2010based therapy in cardiac repair after myocardial infarction: promise, challenges, and future directions","volume":"188","author":"Yan W","year":"2024","journal-title":"J Mol Cell Cardiol"},{"key":"e_1_2_12_189_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/genes10121022","article-title":"Periodontitis and tooth loss have negative systemic impact on circulating progenitor cell levels: a clinical study","volume":"10","author":"Isola G","year":"2019","journal-title":"Genes (Basel)"},{"key":"e_1_2_12_190_1","first-page":"1","article-title":"Homocysteine\u2010induced endothelial dysfunction","volume":"67","author":"Lai WK","year":"2015","journal-title":"Ann Nutr Metab"},{"key":"e_1_2_12_191_1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1139\/cjpp-2018-0112","article-title":"Homocysteine and homocysteine\u2010related compounds: an overview of the roles in the pathology of the cardiovascular and nervous systems","volume":"96","author":"Djuric D","year":"2018","journal-title":"Can J Physiol Pharmacol"},{"key":"e_1_2_12_192_1","doi-asserted-by":"crossref","DOI":"10.3390\/biom11060875","article-title":"Periodontal inflamed surface area mediates the link between homocysteine and blood pressure","volume":"11","author":"Botelho J","year":"2021","journal-title":"Biomolecules"},{"key":"e_1_2_12_193_1","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2024-100140","article-title":"Periodontal disease and cirrhosis: current concepts and future prospects","volume":"3","author":"Hudson D","year":"2025","journal-title":"eGastroenterology"},{"key":"e_1_2_12_194_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.609614","article-title":"Inflammation in periodontal disease: possible link to vascular disease","volume":"11","author":"Paul O","year":"2021","journal-title":"Front Physiol"},{"key":"e_1_2_12_195_1","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/615486","article-title":"Mechanisms of bone resorption in periodontitis","volume":"2015","author":"Hienz SA","year":"2015","journal-title":"J Immunol Res"},{"key":"e_1_2_12_196_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020440","article-title":"Matrix metalloproteinases as regulators of periodontal inflammation","volume":"18","author":"Franco C","year":"2017","journal-title":"Int J Mol Sci"},{"key":"e_1_2_12_197_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2020.07.019","article-title":"Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting","volume":"159","author":"Soppert J","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"e_1_2_12_198_1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41581-021-00423-5","article-title":"Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations","volume":"17","author":"Noels H","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"e_1_2_12_199_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41581-024-00837-x","article-title":"Post\u2010translational modifications in kidney diseases and associated cardiovascular risk","volume":"20","author":"Noels H","year":"2024","journal-title":"Nat Rev Nephrol"},{"key":"e_1_2_12_200_1","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/jcpe.12792","article-title":"Serum lipid levels in patients with periodontal disease: a meta\u2010analysis and meta\u2010regression","volume":"44","author":"Nepomuceno R","year":"2017","journal-title":"J Clin Periodontol"},{"key":"e_1_2_12_201_1","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181665","article-title":"Modified lipoproteins in periodontitis: a link to cardiovascular disease?","volume":"39","author":"Ljunggren S","year":"2019","journal-title":"Biosci Rep"},{"key":"e_1_2_12_202_1","article-title":"Role of serum amyloid a (SAA) protein in various diseases with special reference to periodontal and periapical inflammation\u2010a review","volume":"14","author":"Basheer S","year":"2020","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_12_203_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/JPER.19-0050","article-title":"The interaction between serum amyloid a and toll\u2010like receptor 2 pathway regulates inflammatory cytokine secretion in human gingival fibroblasts","volume":"91","author":"Song L\u2010T","year":"2020","journal-title":"J Periodontol"},{"key":"e_1_2_12_204_1","first-page":"470","article-title":"Asociaci\u00f3n entre niveles patol\u00f3gicos de amiloide A s\u00e9rico y periodontitis","volume":"20","author":"Ardila Medina CM","year":"2016","journal-title":"Rev Arch Med Camaguey"},{"key":"e_1_2_12_205_1","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1007\/s00784-023-05269-8","article-title":"Clinical diagnostic value of IL\u201014, 1L\u201016 and SAA in periodontitis","volume":"27","author":"Lu X","year":"2023","journal-title":"Clin Oral Investig"},{"key":"e_1_2_12_206_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1435054","article-title":"Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets","volume":"15","author":"Neurath N","year":"2024","journal-title":"Front Immunol"},{"key":"e_1_2_12_207_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/prd.12302","article-title":"Periodontal diseases and association with atherosclerotic disease","volume":"83","author":"Herrera D","year":"2020","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_208_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/prd.12621","article-title":"Relationship between periodontitis and systemic diseases: a bibliometric and visual study","volume":"98","author":"Isola G","year":"2025","journal-title":"Periodontol 2000"},{"key":"e_1_2_12_209_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4103\/0972-124X.106878","article-title":"Periodontitis and systemic diseases: a literature review","volume":"16","author":"Arigbede AO","year":"2012","journal-title":"J Indian Soc Periodontol"},{"key":"e_1_2_12_210_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12903-021-02032-x","article-title":"The frequency of periodontitis in end\u2010stage renal disease on hemodialysis in a sample of Egyptian population: multi\u2010center clinical cross\u2010sectional study","volume":"22","author":"Abou\u2010Bakr A","year":"2022","journal-title":"BMC Oral Health"},{"key":"e_1_2_12_211_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2024.102699","article-title":"Could the periodontal therapy improve the cardiologic patient health? A narrative review","volume":"49","author":"Bertoldi C","year":"2024","journal-title":"Curr Probl Cardiol"},{"key":"e_1_2_12_212_1","first-page":"e73","article-title":"Periodontal disease and atherosclerotic cardiovascular disease: a scientific statement from the American Heart Association","volume":"153","author":"Tran AH","year":"2026","journal-title":"Circulation"},{"key":"e_1_2_12_213_1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/jre.13161","article-title":"Demystifying the connection between periodontal disease and chronic kidney disease \u2010 an umbrella review","volume":"58","author":"He I","year":"2023","journal-title":"J Periodontal Res"},{"key":"e_1_2_12_214_1","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1007\/s15010-025-02568-y","article-title":"Bridging oral and systemic health: exploring pathogenesis, biomarkers, and diagnostic innovations in periodontal disease","volume":"53","author":"Foroughi M","year":"2025","journal-title":"Infection"},{"key":"e_1_2_12_215_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1600-0757.2011.00432.x","article-title":"Advanced reconstructive technologies for periodontal tissue repair","volume":"59","author":"Ramseier CA","year":"2012","journal-title":"Periodontol 2000"}],"container-title":["Periodontology 2000"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.70048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/prd.70048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.70048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:37:09Z","timestamp":1785289029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/prd.70048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":214,"alternative-id":["10.1111\/prd.70048"],"URL":"https:\/\/doi.org\/10.1111\/prd.70048","archive":["Portico"],"relation":{},"ISSN":["0906-6713","1600-0757"],"issn-type":[{"value":"0906-6713","type":"print"},{"value":"1600-0757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"2025-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"prd.70048"}}