{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:53:51Z","timestamp":1788602031737,"version":"build-2803163510"},"reference-count":138,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aging is accompanied by a chronic low\u2010grade inflammatory process, known as inflammaging, as well as immunosenescence, an age\u2010related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro\u2010inflammatory factors. These processes alter the host immune regulation and tissue homeostasis. Aging\u2010associated mechanisms are being explored for their role in periodontal and peri\u2010implant diseases because of their promotion of dysregulated inflammation, impaired healing, and heightened susceptibility to tissue destruction. Rather than viewing periodontitis as a condition driven solely by microbial burden, it should be understood as a multifactorial disease shaped by complex host\u2013microbe interactions, in which host\u2010driven processes, particularly senescence and inflammaging, play a central role in amplifying bidirectional oral\u2013systemic interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This scoping review aims to (i) highlight the current understanding of the role of aging and its alterations in host inflammatory responses on immune function, tissue homeostasis, and cellular stress responses; (ii) explore the potential impact of \u201cinflammaging\u201d on the periodontium and interactions with systemic health; and (iii) explore possible therapeutic targets for senotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A literature search of the PubMed database was conducted using Boolean search strategies to identify publications related to the potential connections between aging and inflammation in the context of the oral cavity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the total 283 articles that were screened, 87 met the eligibility criteria and were included in this scoping review. An additional 51 articles were obtained via manual search. The evidence demonstrates a link between inflammaging, age\u2010related cellular senescence, and periodontal vulnerability to periodontal pathogens and periodontal destruction. Both experimental and clinical studies have shown increased senescence markers, dysregulated immune responses, and enhanced osteoclastic activity that lead to greater tissue destruction and alveolar bone loss. Systemic conditions such as Alzheimer's disease, diabetes, and cardiovascular disease can also amplify the inflammatory burden through shared pathways. Overall, our findings support the idea that older adults undergo immune dysregulation when challenged with microbes that ultimately cause a chronic periodontal inflammatory state.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.70049","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:24:02Z","timestamp":1778243042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["From senescence and inflammaging to systemic comorbidities: Drivers of aging\u2010associated periodontitis"],"prefix":"10.1111","author":[{"given":"James","family":"Cheng","sequence":"first","affiliation":[{"name":"Section of Periodontics, Division of Regenerative and Reconstructive Sciences UCLA School of Dentistry  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chew Tin Zar","family":"Aung","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Western University of Health Sciences  Pomona California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel F.","family":"Suslavich","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6089-637X","authenticated-orcid":false,"given":"Sinem Esra","family":"Sahingur","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Innovation and Precision Dentistry, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-0654","authenticated-orcid":false,"given":"Yvonne L.","family":"Hernandez\u2010Kapila","sequence":"additional","affiliation":[{"name":"Section of Periodontics, Division of Regenerative and Reconstructive Sciences UCLA School of Dentistry  Los Angeles California USA"},{"name":"Sections of Biosystems and Function and Periodontics, School of Dentistry University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/prd.12126","article-title":"The aging population: demographics and the biology of aging","volume":"72","author":"Kanasi E","year":"2016","journal-title":"Periodontol 2000"},{"issue":"1","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/prd.12136","article-title":"The subgingival periodontal microbiota of the aging mouth","volume":"72","author":"Feres M","year":"2016","journal-title":"Periodontol 2000"},{"issue":"4","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s40496-018-0202-2","article-title":"Age and periodontal health \u2010 immunological view","volume":"5","author":"Ebersole JL","year":"2018","journal-title":"Curr Oral Health Rep"},{"issue":"1","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/prd.12135","article-title":"Aging, inflammation, immunity and periodontal disease","volume":"72","author":"Ebersole JL","year":"2016","journal-title":"Periodontol 2000"},{"issue":"4","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1007\/s11357-023-00835-0","article-title":"Periodontal disease as a model to study chronic inflammation in aging","volume":"46","author":"Bertolini M","year":"2024","journal-title":"Geroscience"},{"issue":"5","key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/JLB.3MR0822-645RR","article-title":"Immune senescence and periodontitis: from mechanism to therapy","volume":"112","author":"Liu J","year":"2022","journal-title":"J Leukoc Biol"},{"issue":"1","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.adaj.2025.09.018","article-title":"Global and regional incidence burden of periodontal diseases: age\u2010period\u2010cohort analysis from 1992 through 2021 and forecast by 2050","volume":"157","author":"Sun R","year":"2026","journal-title":"J Am Dent Assoc"},{"issue":"2","key":"e_1_2_13_9_1","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.21873\/invivo.13919","article-title":"Global, regional and National Burden of Edentulism and periodontal diseases from 1990 to 2021: analysis of risk factors and prediction of trends in 2050","volume":"39","author":"Feng Y","year":"2025","journal-title":"In Vivo"},{"issue":"2","key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.adaj.2025.09.015","article-title":"The burden of severe periodontitis in the United States: insights from a population\u2010based analysis","volume":"157","author":"Wang Y","year":"2026","journal-title":"J Am Dent Assoc"},{"issue":"1","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11010058","article-title":"Effect of aging on homeostasis in the soft tissue of the periodontium: a narrative review","volume":"11","author":"Kim YG","year":"2021","journal-title":"J Pers Med"},{"issue":"1","key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/jre.12799","article-title":"Cellular ageing of oral fibroblasts differentially modulates extracellular matrix organization","volume":"56","author":"Atkuru S","year":"2021","journal-title":"J Periodontal Res"},{"issue":"6","key":"e_1_2_13_13_1","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2024.13362","article-title":"Cellular senescence: a new perspective on the suppression of periodontitis (review)","volume":"30","author":"Lin XJ","year":"2024","journal-title":"Mol Med Rep"},{"issue":"1","key":"e_1_2_13_14_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/jre.12789","article-title":"Gingival tissue autophagy pathway gene expression profiles in periodontitis and aging","volume":"56","author":"Ebersole JL","year":"2021","journal-title":"J Periodontal Res"},{"issue":"20","key":"e_1_2_13_15_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207441","article-title":"Periodontal disease and senescent cells: new players for an old Oral health problem?","volume":"21","author":"Aquino\u2010Martinez R","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"4","key":"e_1_2_13_16_1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/0022034515625962","article-title":"Effect of aging on periodontal inflammation, microbial colonization, and disease susceptibility","volume":"95","author":"Wu Y","year":"2016","journal-title":"J Dent Res"},{"issue":"5","key":"e_1_2_13_17_1","first-page":"1279","article-title":"Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue","volume":"15","author":"Ikegami K","year":"2023","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"e_1_2_13_18_1","doi-asserted-by":"crossref","DOI":"10.3390\/metabo15010035","article-title":"Impact of periodontitis and Oral Dysbiosis metabolites in the modulation of accelerating ageing and human senescence","volume":"15","author":"Amato M","year":"2025","journal-title":"Metabolites"},{"issue":"1","key":"e_1_2_13_19_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11357-020-00258-1","article-title":"Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging","volume":"43","author":"Akkaoui J","year":"2021","journal-title":"Geroscience"},{"issue":"11","key":"e_1_2_13_20_1","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering10111274","article-title":"Ageing and inflammation: what happens in periodontium?","volume":"10","author":"Zhu L","year":"2023","journal-title":"Bioengineering (Basel)"},{"issue":"4","key":"e_1_2_13_21_1","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1007\/s10266-024-00907-3","article-title":"Associations between immune\u2010inflammatory markers, age, and periodontal status: a cross\u2010sectional study","volume":"112","author":"Ucan Yarkac F","year":"2024","journal-title":"Odontology"},{"issue":"11","key":"e_1_2_13_22_1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1177\/0022034520933533","article-title":"Targeting NLRP3 Inflammasome reduces age\u2010related experimental alveolar bone loss","volume":"99","author":"Zang Y","year":"2020","journal-title":"J Dent Res"},{"issue":"8","key":"e_1_2_13_23_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1177\/00220345231164104","article-title":"FoxO1\/NLRP3 Inflammasome promotes age\u2010related alveolar bone resorption","volume":"102","author":"Wang Z","year":"2023","journal-title":"J Dent Res"},{"issue":"1","key":"e_1_2_13_24_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/prd.12227","article-title":"Periodontal complications with age","volume":"78","author":"Persson GR","year":"2018","journal-title":"Periodontol 2000"},{"issue":"1","key":"e_1_2_13_25_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/prd.12192","article-title":"Dental geriatrics and periodontitis","volume":"74","author":"Persson GR","year":"2017","journal-title":"Periodontol 2000"},{"issue":"3","key":"e_1_2_13_26_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189374","article-title":"Salivary microbial profiles in relation to age, periodontal, and systemic diseases","volume":"13","author":"Lira\u2010Junior R","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"e_1_2_13_27_1","doi-asserted-by":"crossref","DOI":"10.3390\/geriatrics8040079","article-title":"Changes in interleukin\u20101beta, tumor necrosis factor\u2010alpha, and Interleukin\u201010 cytokines in older people with periodontitis","volume":"8","author":"Sumbayak IA","year":"2023","journal-title":"Geriatrics (Basel)"},{"issue":"12","key":"e_1_2_13_28_1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1177\/00220345211009463","article-title":"The contribution of macrophages in old mice to periodontal disease","volume":"100","author":"Clark D","year":"2021","journal-title":"J Dent Res"},{"key":"e_1_2_13_29_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fdmed.2022.844865","article-title":"Cellular mechanisms of Inflammaging and periodontal disease","volume":"3","author":"Clark D","year":"2022","journal-title":"Front Dent Med"},{"issue":"8","key":"e_1_2_13_30_1","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.3390\/cimb45080416","article-title":"Aging aggravates periodontal inflammatory responses and alveolar bone resorption by Porphyromonas gingivalis infection","volume":"45","author":"Song Y","year":"2023","journal-title":"Curr Issues Mol Biol"},{"issue":"1","key":"e_1_2_13_31_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/omi.12121","article-title":"Effects of aging in the expression of NOD\u2010like receptors and inflammasome\u2010related genes in oral mucosa","volume":"31","author":"Ebersole JL","year":"2016","journal-title":"Mol Oral Microbiol"},{"issue":"8","key":"e_1_2_13_32_1","first-page":"447","article-title":"Aging periodontium, aging patient: current concepts","volume":"43","author":"Ryder M","year":"2023","journal-title":"J Calif Dent Assoc"},{"issue":"4","key":"e_1_2_13_33_1","doi-asserted-by":"crossref","DOI":"10.3390\/dj6040058","article-title":"Substantial differences in the subgingival microbiome measured by 16S metagenomics according to periodontitis status in older women","volume":"6","author":"LaMonte MJ","year":"2018","journal-title":"Dent J (Basel)"},{"key":"e_1_2_13_34_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.107717","article-title":"Age\u2010related oral microbiota dysbiosis and systemic diseases","volume":"205","author":"Deng L","year":"2025","journal-title":"Microb Pathog"},{"issue":"2","key":"e_1_2_13_35_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.sdentj.2022.12.010","article-title":"Quantifying red complex bacteria, oral hygiene condition, and inflammation status in elderly: a pilot study","volume":"35","author":"Khoirowati D","year":"2023","journal-title":"Saudi Dent J"},{"issue":"13","key":"e_1_2_13_36_1","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1177\/00220345221110108","article-title":"TLR9 mediates periodontal aging by fostering senescence and Inflammaging","volume":"101","author":"Albuquerque\u2010Souza E","year":"2022","journal-title":"J Dent Res"},{"issue":"4","key":"e_1_2_13_37_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: linking aging to chronic disease","volume":"159","author":"Kennedy BK","year":"2014","journal-title":"Cell"},{"issue":"1","key":"e_1_2_13_38_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and aging\u2010related diseases: from molecular mechanisms to interventions and treatments","volume":"7","author":"Guo J","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"e_1_2_13_39_1","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.18632\/aging.102903","article-title":"Survey of senescent cell markers with age in human tissues","volume":"12","author":"Idda ML","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"11","key":"e_1_2_13_40_1","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.18632\/aging.101617","article-title":"The senescent cell epigenome","volume":"10","author":"Yang N","year":"2018","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"e_1_2_13_41_1","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/s43587-022-00326-5","article-title":"NIH SenNet consortium to map senescent cells throughout the human lifespan to understand physiological health","volume":"2","author":"Consortium S","year":"2022","journal-title":"Nat Aging"},{"key":"e_1_2_13_42_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jare.2024.12.037","article-title":"Multi\u2010omics approach reveals TGF\u2010beta signaling\u2010driven senescence in periodontium stem cells","volume":"76","author":"Li B","year":"2025","journal-title":"J Adv Res"},{"issue":"1","key":"e_1_2_13_43_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/jre.12185","article-title":"Aging and contribution of MyD88 and TRIF to expression of TLR pathway\u2010associated genes following stimulation with Porphyromonas gingivalis","volume":"50","author":"Shaik\u2010Dasthagirisaheb YB","year":"2015","journal-title":"J Periodontal Res"},{"issue":"18","key":"e_1_2_13_44_1","first-page":"S153","article-title":"Age\u2010related changes in immune function (immune senescence) in caries and periodontal diseases: a systematic review","volume":"44","author":"Preshaw PM","year":"2017","journal-title":"J Clin Periodontol"},{"issue":"1","key":"e_1_2_13_45_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s12879-016-1778-6","article-title":"Impact of aging on TREM\u20101 responses in the periodontium: a cross\u2010sectional study in an elderly population","volume":"16","author":"Ozturk VO","year":"2016","journal-title":"BMC Infect Dis"},{"issue":"4","key":"e_1_2_13_46_1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/jre.12996","article-title":"Expression of matrix metalloproteinase\u20103 and \u201010 is up\u2010regulated in the periodontal tissues of aged mice","volume":"57","author":"Kageyama Y","year":"2022","journal-title":"J Periodontal Res"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.11393"},{"key":"e_1_2_13_48_1","article-title":"Inflamm\u2010aging\u2010related cytokines of IL\u201017 and IFN\u2010gamma accelerate Osteoclastogenesis and periodontal destruction","volume":"2021","author":"Tan J","year":"2021","journal-title":"J Immunol Res"},{"issue":"10","key":"e_1_2_13_49_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105365","article-title":"Activation and function of NLRP3 inflammasome in bone and joint\u2010related diseases","volume":"23","author":"Murakami T","year":"2022","journal-title":"Int J Mol Sci"},{"key":"e_1_2_13_50_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115220","article-title":"LPS\u2010induced premature osteocyte senescence: implications in inflammatory alveolar bone loss and periodontal disease pathogenesis","volume":"132","author":"Aquino\u2010Martinez R","year":"2020","journal-title":"Bone"},{"issue":"10","key":"e_1_2_13_51_1","article-title":"Cellular senescence and periodontitis: mechanisms and therapeutics","volume":"11","author":"Chen S","year":"2022","journal-title":"Biology (Basel)"},{"issue":"11","key":"e_1_2_13_52_1","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1007\/s00784-023-05297-4","article-title":"Comparison of immunoexpression of dendritic cells, mast cells and blood vessels in periodontal disease between adults and elderly","volume":"27","author":"Vasconcelos Gurgel BC","year":"2023","journal-title":"Clin Oral Investig"},{"issue":"10","key":"e_1_2_13_53_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: the good, the bad and the unknown","volume":"18","author":"Huang W","year":"2022","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"e_1_2_13_54_1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.14336\/AD.2023.0621","article-title":"Underlying mechanisms and treatment of cellular senescence\u2010induced biological barrier interruption and related diseases","volume":"15","author":"Sun R","year":"2024","journal-title":"Aging Dis"},{"issue":"1","key":"e_1_2_13_55_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tcb.2022.04.011","article-title":"The heterogeneity of cellular senescence: insights at the single\u2010cell level","volume":"33","author":"Cohn RL","year":"2023","journal-title":"Trends Cell Biol"},{"issue":"1","key":"e_1_2_13_56_1","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/s41467-023-37304-3","article-title":"An aging, pathology burden, and glial senescence build\u2010up hypothesis for late onset Alzheimer's disease","volume":"14","author":"Lau V","year":"2023","journal-title":"Nat Commun"},{"issue":"4","key":"e_1_2_13_57_1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI95147","article-title":"Senescent cells and osteoarthritis: a painful connection","volume":"128","author":"Jeon OH","year":"2018","journal-title":"J Clin Invest"},{"issue":"6311","key":"e_1_2_13_58_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis","volume":"354","author":"Childs BG","year":"2016","journal-title":"Science"},{"key":"e_1_2_13_59_1","doi-asserted-by":"crossref","first-page":"14532","DOI":"10.1038\/ncomms14532","article-title":"Cellular senescence mediates fibrotic pulmonary disease","volume":"8","author":"Schafer MJ","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"e_1_2_13_60_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/nyas.14681","article-title":"Extending human healthspan and longevity: a symposium report","volume":"1507","author":"DeVito LM","year":"2022","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.70007"},{"issue":"4","key":"e_1_2_13_62_1","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13778","article-title":"SLC30A4\u2010AS1 mediates the senescence of periodontal ligament stem cells in inflammatory environments via the alternative splicing of TP53BP1","volume":"58","author":"Xu M","year":"2025","journal-title":"Cell Prolif"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-025-00600-2"},{"issue":"21","key":"e_1_2_13_64_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218103","article-title":"Aging\u2010affected MSC functions and severity of periodontal tissue destruction in a ligature\u2010induced mouse periodontitis model","volume":"21","author":"Aung KT","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"4","key":"e_1_2_13_65_1","first-page":"3123","article-title":"TGF\u2010beta induces periodontal ligament stem cell senescence through increase of ROS production","volume":"20","author":"Fan C","year":"2019","journal-title":"Mol Med Rep"},{"issue":"3","key":"e_1_2_13_66_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/omi.12167","article-title":"Caveolin\u20101 serves as a negative effector in senescent human gingival fibroblasts during fusobacterium nucleatum infection","volume":"32","author":"Ahn SH","year":"2017","journal-title":"Mol Oral Microbiol"},{"issue":"6","key":"e_1_2_13_67_1","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1007\/s10753-024-02014-5","article-title":"ROS\u2010induced gingival fibroblast senescence: implications in exacerbating inflammatory responses in periodontal disease","volume":"47","author":"Guo S","year":"2024","journal-title":"Inflammation"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.96908"},{"issue":"8","key":"e_1_2_13_69_1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1177\/00220345241255325","article-title":"Molecular signatures of senescence in periodontitis: clinical insights","volume":"103","author":"Rattanaprukskul K","year":"2024","journal-title":"J Dent Res"},{"issue":"2","key":"e_1_2_13_70_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/omi.12432","article-title":"Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells","volume":"39","author":"Albuquerque\u2010Souza E","year":"2024","journal-title":"Mol Oral Microbiol"},{"issue":"1","key":"e_1_2_13_71_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25010005","article-title":"Biological effects of \u201cInflammageing\u201d on human Oral cells: insights into a potential confounder of age\u2010related diseases","volume":"25","author":"Alexakou E","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"e_1_2_13_72_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.14336\/AD.2022.0623","article-title":"Microbially\u2010induced exosomes from dendritic cells promote paracrine immune senescence: novel mechanism of bone degenerative disease in mice","volume":"14","author":"Elsayed R","year":"2023","journal-title":"Aging Dis"},{"key":"e_1_2_13_73_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.669989","article-title":"Porphyromonas gingivalis provokes exosome secretion and paracrine immune senescence in bystander dendritic cells","volume":"11","author":"Elsayed R","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"issue":"3","key":"e_1_2_13_74_1","doi-asserted-by":"crossref","DOI":"10.3390\/cells14030226","article-title":"The role of senescence in experimental periodontitis at the causal level: An in\u00a0vivo study","volume":"14","author":"Chu X","year":"2025","journal-title":"Cells"},{"issue":"10","key":"e_1_2_13_75_1","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1007\/s00784-023-05211-y","article-title":"Porphyromonas gingivalis enhances the senescence\u2010induced increase of 5\u2010alpha reductase in gingival fibroblasts","volume":"27","author":"Ozkan Karasu Y","year":"2023","journal-title":"Clin Oral Investig"},{"issue":"10","key":"e_1_2_13_76_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26104959","article-title":"Activating transcription factor 3 (ATF3) regulates cellular senescence and Osteoclastogenesis via STAT3\/ERK and p65\/AP\u20101 pathways in human periodontal ligament cells","volume":"26","author":"Bae WJ","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"1","key":"e_1_2_13_77_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/prd.12429","article-title":"Periodontal microorganisms and Alzheimer disease \u2010 a causative relationship?","volume":"89","author":"Jungbauer G","year":"2022","journal-title":"Periodontol 2000"},{"key":"e_1_2_13_78_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbi.2019.07.002","article-title":"Systemic inflammation linking chronic periodontitis to cognitive decline","volume":"81","author":"Wang RP","year":"2019","journal-title":"Brain Behav Immun"},{"issue":"4","key":"e_1_2_13_79_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/jre.12863","article-title":"Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation","volume":"56","author":"Zhang P","year":"2021","journal-title":"J Periodontal Res"},{"issue":"2","key":"e_1_2_13_80_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/gerona\/glaa096","article-title":"Poor Oral health and inflammatory, hemostatic, and cardiac biomarkers in older age: results from two studies in the UK and USA","volume":"76","author":"Kotronia E","year":"2021","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_2_13_81_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-3-031-79146-8_11","article-title":"Oral diseases are associated with cognitive decline and dementia","volume":"1472","author":"Gao C","year":"2025","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"e_1_2_13_82_1","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1002\/alz.13683","article-title":"Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging","volume":"20","author":"Rubinstein T","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"12","key":"e_1_2_13_83_1","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1177\/00220345221102084","article-title":"Neuroinflammation: a distal consequence of periodontitis","volume":"101","author":"Li X","year":"2022","journal-title":"J Dent Res"},{"issue":"9","key":"e_1_2_13_84_1","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1007\/s10787-025-01888-7","article-title":"The link between oral health and neurodegeneration: a review of periodontitis in Alzheimer's and Parkinson's disease and dementia","volume":"33","author":"Wagaskar P","year":"2025","journal-title":"Inflammopharmacology"},{"key":"e_1_2_13_85_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1044334","article-title":"Aging envisage imbalance of the periodontium: a keystone in oral disease and systemic health","volume":"13","author":"Villalobos V","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"e_1_2_13_86_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/prd.12389","article-title":"Alzheimer disease and the periodontal patient: new insights, connections, and therapies","volume":"87","author":"Ryder MI","year":"2021","journal-title":"Periodontol 2000"},{"issue":"1","key":"e_1_2_13_87_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/prd.12129","article-title":"Oral inflammation and infection, and chronic medical diseases: implications for the elderly","volume":"72","author":"Scannapieco FA","year":"2016","journal-title":"Periodontol 2000"},{"issue":"4","key":"e_1_2_13_88_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.job.2021.08.007","article-title":"Pathophysiological association between periodontal disease and Alzheimer's disease: importance of periodontal health in the elderly","volume":"63","author":"Desta NT","year":"2021","journal-title":"J Oral Biosci"},{"issue":"22","key":"e_1_2_13_89_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16224558","article-title":"Oral health status and need for Oral Care in an Aging Population: a systematic review","volume":"16","author":"Lauritano D","year":"2019","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"e_1_2_13_90_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/prd.12631","article-title":"The role of the oral microbiome, host response, and periodontal disease treatment in Alzheimer's disease: a primer","volume":"98","author":"Chalmers JC","year":"2025","journal-title":"Periodontol 2000"},{"key":"e_1_2_13_91_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2147\/JIR.S255309","article-title":"Periodontal disease and periodontal disease\u2010related bacteria involved in the pathogenesis of Alzheimer's disease","volume":"13","author":"Matsushita K","year":"2020","journal-title":"J Inflamm Res"},{"issue":"1","key":"e_1_2_13_92_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12974-023-02915-6","article-title":"Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer's disease\u2010like neuroinflammation triggered by periodontal disease","volume":"20","author":"Zhao C","year":"2023","journal-title":"J Neuroinflammation"},{"issue":"1","key":"e_1_2_13_93_1","first-page":"47","article-title":"Systemic health implications of the leaky barriers within the Oral\u2010gut\u2010brain Axis and its pathways of communication","volume":"10","author":"Kim RY","year":"2025","journal-title":"Eur Med J (Chelmsf)"},{"issue":"1","key":"e_1_2_13_94_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12974-023-02747-4","article-title":"IL\u20101beta and TNF\u2010alpha play an important role in modulating the risk of periodontitis and Alzheimer's disease","volume":"20","author":"Wang RP","year":"2023","journal-title":"J Neuroinflammation"},{"issue":"1","key":"e_1_2_13_95_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41368-024-00332-w","article-title":"The impact of aging on neutrophil functions and the contribution to periodontitis","volume":"17","author":"Wang Z","year":"2025","journal-title":"Int J Oral Sci"},{"issue":"8","key":"e_1_2_13_96_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084509","article-title":"Oral Microbially\u2010induced small extracellular vesicles cross the blood\u2010brain barrier","volume":"25","author":"Elashiry M","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"11","key":"e_1_2_13_97_1","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.4103\/1673-5374.310672","article-title":"Oral frailty and neurodegeneration in Alzheimer's disease","volume":"16","author":"Dibello V","year":"2021","journal-title":"Neural Regen Res"},{"issue":"1","key":"e_1_2_13_98_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/prd.12380","article-title":"Frailty, aging, and periodontal disease: basic biologic considerations","volume":"87","author":"Clark D","year":"2021","journal-title":"Periodontol 2000"},{"issue":"8","key":"e_1_2_13_99_1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1177\/00220345231181885","article-title":"Aging and Oral health: biological and Sociobehavioral perspectives","volume":"102","author":"Colombo AP","year":"2023","journal-title":"J Dent Res"},{"issue":"8","key":"e_1_2_13_100_1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/JPER.22-0445","article-title":"Relationship between circulating senescence\u2010associated secretory phenotype levels and severity of type 2 diabetes\u2010associated periodontitis: a cross\u2010sectional study","volume":"94","author":"Song X","year":"2023","journal-title":"J Periodontol"},{"issue":"8","key":"e_1_2_13_101_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2025.0294","article-title":"Clinical significance of aging\u2010related secretory phenotypic factors in diagnosing type 2 diabetes mellitus\u2010associated Peri\u2010Implantitis: a retrospective analysis","volume":"86","author":"Chen W","year":"2025","journal-title":"Br J Hosp Med (Lond)"},{"issue":"14","key":"e_1_2_13_102_1","first-page":"S153","article-title":"Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta\u2010analysis","volume":"40","author":"Engebretson S","year":"2013","journal-title":"J Clin Periodontol"},{"issue":"2","key":"e_1_2_13_103_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2337\/dc09-1378","article-title":"Effect of periodontal treatment on glycemic control of diabetic patients: a systematic review and meta\u2010analysis","volume":"33","author":"Teeuw WJ","year":"2010","journal-title":"Diabetes Care"},{"issue":"1","key":"e_1_2_13_104_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20010502","article-title":"Functional dentition, chronic periodontal disease and frailty in older adults\u2010a narrative review","volume":"20","author":"Yan GLK","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"e_1_2_13_105_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/0022034520957233","article-title":"Tooth loss and dementia: a critical examination","volume":"100","author":"Thomson WM","year":"2021","journal-title":"J Dent Res"},{"issue":"2","key":"e_1_2_13_106_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/00220345211037977","article-title":"Periodontitis and accelerated biological aging: a Geroscience approach","volume":"101","author":"Baima G","year":"2022","journal-title":"J Dent Res"},{"issue":"2","key":"e_1_2_13_107_1","first-page":"145","article-title":"Biological aging and periodontal disease: analysis of NHANES (2001\u20102002)","volume":"7","author":"Nguyen LM","year":"2022","journal-title":"JDR Clin Trans Res"},{"issue":"6","key":"e_1_2_13_108_1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/jcpe.14125","article-title":"Serum nutrients, periodontitis and biological ageing","volume":"52","author":"Nguyen LM","year":"2025","journal-title":"J Clin Periodontol"},{"issue":"8","key":"e_1_2_13_109_1","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1177\/00220345231154567","article-title":"The emerging role of accelerated cellular senescence in periodontitis","volume":"102","author":"Aquino\u2010Martinez R","year":"2023","journal-title":"J Dent Res"},{"issue":"5","key":"e_1_2_13_110_1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/febs.16350","article-title":"Targeting cellular senescence with senotherapeutics: senolytics and senomorphics","volume":"290","author":"Zhang L","year":"2023","journal-title":"FEBS J"},{"issue":"8","key":"e_1_2_13_111_1","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41591-022-01923-y","article-title":"Cellular senescence and senolytics: the path to the clinic","volume":"28","author":"Chaib S","year":"2022","journal-title":"Nat Med"},{"key":"e_1_2_13_112_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107505","article-title":"Fisetin attenuates periodontitis through FGFR1\/TLR4\/NLRP3 inflammasome pathway","volume":"95","author":"Huang X","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"e_1_2_13_113_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/joim.13141","article-title":"Senolytic drugs: from discovery to translation","volume":"288","author":"Kirkland JL","year":"2020","journal-title":"J Intern Med"},{"key":"e_1_2_13_114_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2026.106124","article-title":"Senolytics, dasatanib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease","volume":"124","author":"Bian X","year":"2026","journal-title":"EBioMedicine"},{"issue":"38","key":"e_1_2_13_115_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000022241","article-title":"Quercetin inhibits TNF\u2010\u03b1 induced HUVECs apoptosis and inflammation via downregulating NF\u2010kB and AP\u20101 signaling pathway in\u00a0vitro","volume":"99","author":"Chen T","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"e_1_2_13_116_1","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1111\/odi.15291","article-title":"Dasatinib and quercetin mitigate age\u2010related alveolar bone Inflammaging and neutrophil infiltration","volume":"31","author":"Tang J","year":"2025","journal-title":"Oral Dis"},{"key":"e_1_2_13_117_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson LJ","year":"2019","journal-title":"EBioMedicine"},{"issue":"2","key":"e_1_2_13_118_1","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13767","article-title":"Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age","volume":"22","author":"Islam MT","year":"2023","journal-title":"Aging Cell"},{"key":"e_1_2_13_119_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115653","article-title":"Quercetin improves cerebral ischemia\/reperfusion injury by promoting microglia\/macrophages M2 polarization via regulating PI3K\/Akt\/NF\u2010\u03baB signaling pathway","volume":"168","author":"Li L","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"e_1_2_13_120_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.999752","article-title":"Promising bioactive properties of quercetin for potential food applications and health benefits: a review","volume":"9","author":"Shabir I","year":"2022","journal-title":"Front Nutr"},{"issue":"1","key":"e_1_2_13_121_1","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1038\/s41467-021-25453-2","article-title":"Long\u2010term treatment with senolytic drugs Dasatinib and quercetin ameliorates age\u2010dependent intervertebral disc degeneration in mice","volume":"12","author":"Novais EJ","year":"2021","journal-title":"Nat Commun"},{"issue":"4","key":"e_1_2_13_122_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/00220345241299789","article-title":"Dasatinib and quercetin limit gingival senescence, inflammation, and bone loss","volume":"104","author":"Rattanaprukskul K","year":"2025","journal-title":"J Dent Res"},{"key":"e_1_2_13_123_1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: results from a first\u2010in\u2010human, open\u2010label, pilot study","volume":"40","author":"Justice JN","year":"2019","journal-title":"EBioMedicine"},{"key":"e_1_2_13_124_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104481","article-title":"Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single\u2010blind, single\u2010center, randomized, placebo\u2010controlled pilot trial on feasibility and tolerability","volume":"90","author":"Nambiar A","year":"2023","journal-title":"EBioMedicine"},{"key":"e_1_2_13_125_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.774273","article-title":"Quercetin preserves Oral cavity health by mitigating inflammation and microbial Dysbiosis","volume":"12","author":"Mooney EC","year":"2021","journal-title":"Front Immunol"},{"key":"e_1_2_13_126_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ebiom.2018.09.015","article-title":"Fisetin is a senotherapeutic that extends health and lifespan","volume":"36","author":"Yousefzadeh MJ","year":"2018","journal-title":"EBioMedicine"},{"issue":"3","key":"e_1_2_13_127_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031707","article-title":"Fisetin deters cell proliferation, induces apoptosis, alleviates oxidative stress and inflammation in human cancer cells, HeLa","volume":"23","author":"Afroze N","year":"2022","journal-title":"Int J Mol Sci"},{"key":"e_1_2_13_128_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2024.111995","article-title":"Fisetin as a senotherapeutic agent: evidence and perspectives for age\u2010related diseases","volume":"222","author":"Tavenier J","year":"2024","journal-title":"Mech Ageing Dev"},{"issue":"1","key":"e_1_2_13_129_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1186\/s12951-025-03907-9","article-title":"Fisetin carbon dots alleviate periodontitis by enhancing mitophagy through regulation of sirtuin 3 SUMOylation","volume":"23","author":"Deng Y","year":"2025","journal-title":"J Nanobiotechnol"},{"issue":"4","key":"e_1_2_13_130_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu GY","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"e_1_2_13_131_1","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6292630","article-title":"mTOR inhibition rejuvenates the aging gingival fibroblasts through alleviating oxidative stress","volume":"2017","author":"Xia Y","year":"2017","journal-title":"Oxidative Med Cell Longev"},{"key":"e_1_2_13_132_1","first-page":"9","article-title":"Rapamycin rejuvenates oral health in aging mice","volume":"9","author":"An JY","year":"2020","journal-title":"elife"},{"key":"e_1_2_13_133_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114517","article-title":"Rapamycin ameliorates senescence of periodontal ligament stem cells and promotes their osteogenesis via the PI3K\/AKT pathway","volume":"153","author":"Zheng Z","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"e_1_2_13_134_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2165\/11534750-000000000-00000","article-title":"Clinical pharmacokinetics of metformin","volume":"50","author":"Graham GG","year":"2011","journal-title":"Clin Pharmacokinet"},{"issue":"1","key":"e_1_2_13_135_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2020.04.001","article-title":"Benefits of metformin in attenuating the hallmarks of aging","volume":"32","author":"Kulkarni AS","year":"2020","journal-title":"Cell Metab"},{"key":"e_1_2_13_136_1","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2023.1170434","article-title":"Metformin mitigates SASP secretion and LPS\u2010triggered hyper\u2010inflammation in doxorubicin\u2010induced senescent endothelial cells","volume":"4","author":"Abdelgawad IY","year":"2023","journal-title":"Front Aging"},{"issue":"6","key":"e_1_2_13_137_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e27478","article-title":"Metformin alleviates junctional epithelium senescence via the AMPK\/SIRT1\/autophagy pathway in periodontitis induced by hyperglycemia","volume":"10","author":"Ye X","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"e_1_2_13_138_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10522-019-09838-x","article-title":"Metformin prevents against oxidative stress\u2010induced senescence in human periodontal ligament cells","volume":"21","author":"Kuang Y","year":"2020","journal-title":"Biogerontology"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.08.056"}],"container-title":["Periodontology 2000"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.70049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/prd.70049","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.70049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:24:17Z","timestamp":1778243057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/prd.70049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":138,"alternative-id":["10.1111\/prd.70049"],"URL":"https:\/\/doi.org\/10.1111\/prd.70049","archive":["Portico"],"relation":{},"ISSN":["0906-6713","1600-0757"],"issn-type":[{"value":"0906-6713","type":"print"},{"value":"1600-0757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"prd.70049"}}