{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:59:57Z","timestamp":1785286797094,"version":"3.55.0"},"reference-count":206,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome\u2010mediated interventions as a novel cell\u2010free regenerative approach for hair regeneration across multiple alopecia subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative\u2010scoping review was performed utilizing PubMed, Scopus, and Web of Science databases, identifying 80 preclinical and clinical studies. Eligible studies evaluated exosome\u2010based mechanisms, delivery systems, and treatment outcomes in hair regeneration without restriction on publication year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Exosomes derived from diverse origins (mesenchymal stem cells, hair follicle cells, blood, and plant\u2010mediated platforms) consistently enhanced hair regeneration via stimulating the Wnt\/\u03b2\u2010catenin pathway, promoting VEGF\u2010regulated angiogenesis, and suppressing TGF\u2010\u03b2\/SMAD\u2010mediated fibrosis and immune\u2010regulated follicular injury. Preclinical studies showed expedited telogen\u2010to\u2010anagen shift, increased follicular proliferation, and enhanced hair shaft properties. Clinical evidence from 11 studies (&gt;330 patients) showed significant increases in hair density (25\u201335 hairs\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ), shaft thickness, and patient satisfaction, with impacts sustained up to 1\u2009year. Novel delivery approaches, including microneedles and hydrogels, further improved treatment efficacy. Reported side effects were transient and mild.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exosome\u2010mediated interventions represent a promising, biologically targeted strategy for alopecia treatment, providing immunoregulatory and regenerative advantages superior to traditional approaches. Nonetheless, standardization of manufacturing, regulatory approval, and large\u2010scale randomized controlled trials are needed before routine clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.70057","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:34:29Z","timestamp":1785285269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Understanding Exosomes in Hair Regeneration"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-9795","authenticated-orcid":false,"given":"Paras","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Research Advanced PRF Education  Jupiter Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Davies","sequence":"additional","affiliation":[{"name":"ZD Hair Clinic  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5477","authenticated-orcid":false,"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-3418","authenticated-orcid":false,"given":"Richard J.","family":"Miron","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"8","key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1111\/jocd.15008","article-title":"Exosome therapy in hair regeneration: a literature review of the evidence, challenges, and future opportunities","volume":"21","author":"Kost Y","year":"2022","journal-title":"J Cosmet Dermatol"},{"issue":"3","key":"e_1_2_14_3_1","article-title":"A Scoping Review of Exosome Delivery Applications in Hair Loss","volume":"17","author":"Schaffer S","year":"2025","journal-title":"Cureus"},{"issue":"7522","key":"e_1_2_14_4_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/bmj.331.7522.951","article-title":"The psychological impact of alopecia","volume":"331","author":"Hunt N","year":"2005","journal-title":"BMJ"},{"issue":"1","key":"e_1_2_14_5_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s13555-018-0278-6","article-title":"The role of vitamins and minerals in hair loss: a review","volume":"9","author":"Almohanna HM","year":"2019","journal-title":"Dermatol Ther"},{"issue":"2","key":"e_1_2_14_6_1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2133.2004.05785.x","article-title":"Minoxidil: mechanisms of action on hair growth","volume":"150","author":"Messenger A","year":"2004","journal-title":"Br J Dermatol"},{"issue":"1","key":"e_1_2_14_7_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1046\/j.1523-1747.2003.12167.x","article-title":"Use of finasteride in the treatment of men with androgenetic alopecia (male pattern hair loss)","volume":"8","author":"Shapiro J","year":"2003","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"12","key":"e_1_2_14_8_1","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1111\/jocd.14537","article-title":"Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics","volume":"20","author":"Nestor MS","year":"2021","journal-title":"J Cosmet Dermatol"},{"issue":"8","key":"e_1_2_14_9_1","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s13555-023-00974-4","article-title":"Use of 5\u2010alpha reductase inhibitors in dermatology: a narrative review","volume":"13","author":"Escamilla\u2010Cruz M","year":"2023","journal-title":"Dermatol Ther"},{"issue":"4","key":"e_1_2_14_10_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4103\/JCAS.JCAS_218_20","article-title":"Role of low\u2010level light therapy (LLLT) in androgenetic alopecia","volume":"14","author":"Pillai JK","year":"2021","journal-title":"J Cutan Aesthet Surg"},{"issue":"2","key":"e_1_2_14_11_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/lsm.22170","article-title":"Low\u2010level laser (light) therapy (LLLT) for treatment of hair loss","volume":"46","author":"Avci P","year":"2014","journal-title":"Lasers Surg Med"},{"issue":"4","key":"e_1_2_14_12_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/jdv.14722","article-title":"Microneedling for the treatment of hair loss?","volume":"32","author":"Fertig R","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"4","key":"e_1_2_14_13_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/JCAS.JCAS_130_17","article-title":"A randomized controlled, single\u2010observer blinded study to determine the efficacy of topical minoxidil plus microneedling versus topical minoxidil alone in the treatment of androgenetic alopecia","volume":"11","author":"Kumar MK","year":"2018","journal-title":"J Cutan Aesthet Surg"},{"key":"e_1_2_14_14_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jconrel.2020.06.019","article-title":"Controlled drug delivery for alopecia: A review","volume":"325","author":"Salim S","year":"2020","journal-title":"J Control Release"},{"issue":"4","key":"e_1_2_14_15_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00004836-200110000-00006","article-title":"Side effects of corticosteroid therapy","volume":"33","author":"Buchman AL","year":"2001","journal-title":"J Clin Gastroenterol"},{"issue":"2","key":"e_1_2_14_16_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/idoj.idoj_483_21","article-title":"Delineating injectable triamcinolone\u2010induced cutaneous atrophy and therapeutic options in 24 patients\u2014a retrospective study","volume":"13","author":"Sharma RK","year":"2022","journal-title":"Indian Dermatol Online J"},{"issue":"3","key":"e_1_2_14_17_1","first-page":"333","article-title":"Hair follicle\u2010targeting drug delivery strategies for the management of hair follicle\u2010associated disorders","volume":"17","author":"Gu Y","year":"2022","journal-title":"Asian J Pharm Sci"},{"issue":"1","key":"e_1_2_14_18_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijwd.2018.08.004","article-title":"Platelet\u2010rich plasma for androgenetic alopecia: a review of the literature and proposed treatment protocol","volume":"5","author":"Stevens J","year":"2019","journal-title":"Int J Women's Dermatol"},{"issue":"7","key":"e_1_2_14_19_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00784-025-06422-1","article-title":"Mechanistic insights into periodontal ligament stem cell\u2010derived exosomes in tissue regeneration","volume":"29","author":"Ahmad P","year":"2025","journal-title":"Clin Oral Investig"},{"issue":"1","key":"e_1_2_14_20_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/prd.12520","article-title":"Understanding exosomes: Part 1\u2014Characterization, quantification and isolation techniques","volume":"94","author":"Miron RJ","year":"2024","journal-title":"Periodontol"},{"key":"e_1_2_14_21_1","first-page":"51","article-title":"The Feasibility of Exosome\u2010Enriched Platelet\u2010rich Fibrin (PRF) for the Treatment of Gingival Recessions: A Case Series of 27 Patients","volume":"24","author":"Froum S","year":"2026","journal-title":"Oral Health Prev Dent"},{"issue":"1","key":"e_1_2_14_22_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41368-025-00370-y","article-title":"Isolation methods of exosomes derived from dental stem cells","volume":"17","author":"Ahmad P","year":"2025","journal-title":"Int J Oral Sci"},{"issue":"1","key":"e_1_2_14_23_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/prd.12561","article-title":"Understanding exosomes: Part 2\u2014Emerging leaders in regenerative medicine","volume":"94","author":"Miron RJ","year":"2024","journal-title":"Periodontol"},{"issue":"3","key":"e_1_2_14_24_1","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.71039","article-title":"Effects of Periodontal\u2010Specific Exosomes and rhBMP2 on Osteogenic Behaviour and Differentiation of BMSCs","volume":"30","author":"Ahmad P","year":"2026","journal-title":"J Cell Mol Med"},{"key":"e_1_2_14_25_1","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/iej.14269","article-title":"Mechanistic insights into dental stem cells\u2010derived exosomes in regenerative endodontics","volume":"58","author":"Ahmad P","year":"2025","journal-title":"Int Endod J"},{"key":"e_1_2_14_26_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11607\/prd.7567","article-title":"Exosome\u2010mediated alveolar ridge augmentation: a first human case report with histology","volume":"46","author":"Estrin N","year":"2025","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"1","key":"e_1_2_14_27_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/prd.12557","article-title":"Understanding exosomes: Part 3\u2014therapeutic+ diagnostic potential in dentistry","volume":"94","author":"Miron RJ","year":"2024","journal-title":"Periodontol"},{"issue":"2","key":"e_1_2_14_28_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s40883-021-00204-3","article-title":"Exploring the potential of mesenchymal stem cell\u2013derived exosomes for the treatment of alopecia","volume":"7","author":"Ajit A","year":"2021","journal-title":"Regenerative Engineering and Translational Medicine"},{"issue":"4","key":"e_1_2_14_29_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/DSS.0000000000004480","article-title":"Exosomes for treating hair loss: a review of clinical studies","volume":"51","author":"Queen D","year":"2025","journal-title":"Dermatologic Surg"},{"issue":"9","key":"e_1_2_14_30_1","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1111\/jocd.15869","article-title":"Systematic review of exosome treatment in hair restoration: Preliminary evidence, safety, and future directions","volume":"22","author":"Gupta AK","year":"2023","journal-title":"J Cosmet Dermatol"},{"issue":"3","key":"e_1_2_14_31_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2022.06.698","article-title":"35326 Exosome therapy for scalp hair growth\u2014A review of the in\u00a0vivo and in\u00a0vitro evidence","volume":"87","author":"Paiewonsky B","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_14_32_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.963278","article-title":"Application of cell\u2010derived extracellular vesicles and engineered nanovesicles for hair growth: from mechanisms to therapeutics","volume":"10","author":"Gangadaran P","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"e_1_2_14_33_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/ijd.12362","article-title":"The human hair: from anatomy to physiology","volume":"53","author":"Buffoli B","year":"2014","journal-title":"Int J Dermatol"},{"issue":"4","key":"e_1_2_14_34_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.fsc.2018.06.003","article-title":"Hair Biology: Growth and Pigmentation","volume":"26","author":"Park AM","year":"2018","journal-title":"Facial Plast Surg Clin North Am"},{"issue":"1","key":"e_1_2_14_35_1","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10235","article-title":"Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls","volume":"7","author":"Abreu CM","year":"2022","journal-title":"Bioeng Transl Med"},{"issue":"1","key":"e_1_2_14_36_1","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70152","article-title":"Exosome\u2010derived long non\u2010coding RNA AC010789. 1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8\/Wnt\/\u03b2\u2010catenin signalling","volume":"15","author":"Chu S","year":"2025","journal-title":"Clin Transl Med"},{"key":"e_1_2_14_37_1","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.2147\/CCID.S465963","article-title":"The roles of exosomes in regulating hair follicle growth","volume":"17","author":"Cheng M","year":"2024","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"7","key":"e_1_2_14_38_1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a015180","article-title":"The dermal papilla: an instructive niche for epithelial stem and progenitor cells in development and regeneration of the hair follicle","volume":"4","author":"Morgan BA","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_2_14_39_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.899095","article-title":"Morphogenesis, growth cycle and molecular regulation of hair follicles","volume":"10","author":"Lin X","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"e_1_2_14_40_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.933370","article-title":"Hair follicle morphogenesis during embryogenesis, neogenesis, and organogenesis","volume":"10","author":"Park S","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"e_1_2_14_41_1","article-title":"Hair follicle stem cells as a skin\u2010organizing signaling center during adult homeostasis","volume":"40","author":"Li KN","year":"2021","journal-title":"EMBO J"},{"key":"e_1_2_14_42_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jconrel.2024.07.066","article-title":"Hybrid hair follicle stem cell extracellular vesicles co\u2010delivering finasteride and gold nanoparticles for androgenetic alopecia treatment","volume":"373","author":"Wu X","year":"2024","journal-title":"J Control Release"},{"issue":"1","key":"e_1_2_14_43_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-021-02527-y","article-title":"A systematic summary of survival and death signalling during the life of hair follicle stem cells","volume":"12","author":"Hu X\u2010M","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"e_1_2_14_44_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/burnst\/tkac022","article-title":"Regulation of signaling pathways in hair follicle stem cells","volume":"10","author":"Wang X","year":"2022","journal-title":"Burns Trauma"},{"issue":"12","key":"e_1_2_14_45_1","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/stem.2696","article-title":"Concise review: mechanisms of quiescent hair follicle stem cell regulation","volume":"35","author":"Yi R","year":"2017","journal-title":"Stem Cells"},{"issue":"7958","key":"e_1_2_14_46_1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s41586-023-05960-6","article-title":"Dedifferentiation maintains melanocyte stem cells in a dynamic niche","volume":"616","author":"Sun Q","year":"2023","journal-title":"Nature"},{"issue":"3","key":"e_1_2_14_47_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3949\/ccjm.88a.20014","article-title":"Male and female pattern hair loss: Treatable and worth treating","volume":"88","author":"Tamashunas NL","year":"2021","journal-title":"Cleve Clin J Med"},{"issue":"3","key":"e_1_2_14_48_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ad.2014.07.006","article-title":"Histologic features of alopecias\u2013part I: nonscarring alopecias","volume":"106","author":"Bern\u00e1rdez C","year":"2015","journal-title":"Actas Dermosifiliogr (Engl Ed)"},{"issue":"21","key":"e_1_2_14_49_1","article-title":"The diagnosis and treatment of hair and scalp diseases","volume":"113","author":"Wolff H","year":"2016","journal-title":"Dtsch Arztebl Int"},{"issue":"6","key":"e_1_2_14_50_1","first-page":"371","article-title":"Hair loss: common causes and treatment","volume":"96","author":"Phillips TG","year":"2017","journal-title":"Am Fam Physician"},{"key":"e_1_2_14_51_1","volume-title":"StatPearls","author":"Al Aboud AM","year":"2024"},{"issue":"1","key":"e_1_2_14_52_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41572-025-00656-9","article-title":"Androgenetic alopecia","volume":"11","author":"Liu Y","year":"2025","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"e_1_2_14_53_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1440-0960.2011.00745.x","article-title":"Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: an update of what we now know","volume":"52","author":"Yip L","year":"2011","journal-title":"Australas J Dermatol"},{"issue":"3","key":"e_1_2_14_54_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/bjd.12716","article-title":"Analysis of quantitative changes in hair growth during treatment with chemotherapy or tamoxifen in patients with breast cancer: a cohort study","volume":"170","author":"Kanti V","year":"2014","journal-title":"Br J Dermatol"},{"issue":"2","key":"e_1_2_14_55_1","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/S1470-2045(12)70553-3","article-title":"Pathobiology of chemotherapy\u2010induced hair loss","volume":"14","author":"Paus R","year":"2013","journal-title":"Lancet Oncol"},{"issue":"5","key":"e_1_2_14_56_1","doi-asserted-by":"crossref","first-page":"E442","DOI":"10.1002\/ijc.29115","article-title":"Efficacy of interventions for prevention of chemotherapy\u2010induced alopecia: A systematic review and meta\u2010analysis","volume":"136","author":"Shin H","year":"2015","journal-title":"Int J Cancer"},{"issue":"1","key":"e_1_2_14_57_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0190-9622(96)90500-9","article-title":"A randomized trial of minoxidil in chemotherapy\u2010induced alopecia","volume":"35","author":"Duvic M","year":"1996","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"e_1_2_14_58_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/DAD.0b013e3181fcfc25","article-title":"Permanent alopecia after systemic chemotherapy: a clinicopathological study of 10 cases","volume":"33","author":"Miteva M","year":"2011","journal-title":"Am J Dermatopathol"},{"key":"e_1_2_14_59_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c3671","article-title":"Management of alopecia areata","volume":"341","author":"Harries M","year":"2010","journal-title":"BMJ"},{"issue":"5","key":"e_1_2_14_60_1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1365-2133.2012.10955.x","article-title":"British Association of Dermatologists' guidelines for the management of alopecia areata 2012","volume":"166","author":"Messenger A","year":"2012","journal-title":"Br J Dermatol"},{"issue":"3","key":"e_1_2_14_61_1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jaad.2006.05.008","article-title":"Alopecia areata: a long term follow\u2010up study of 191 patients","volume":"55","author":"Tosti A","year":"2006","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"e_1_2_14_62_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jaad.2010.08.032","article-title":"Comorbidity profiles among patients with alopecia areata: the importance of onset age, a nationwide population\u2010based study","volume":"65","author":"Chu S\u2010Y","year":"2011","journal-title":"J Am Acad Dermatol"},{"issue":"7302","key":"e_1_2_14_63_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature09114","article-title":"Genome\u2010wide association study in alopecia areata implicates both innate and adaptive immunity","volume":"466","author":"Petukhova L","year":"2010","journal-title":"Nature"},{"issue":"1","key":"e_1_2_14_64_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2017.11","article-title":"Alopecia areata","volume":"3","author":"Pratt CH","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"e_1_2_14_65_1","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/jidsymp.2013.3","article-title":"Genes and immune response in alopecia areata: review of the alopecia areata research summit first day proceedings","volume":"16","author":"Norris DA","year":"2013","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"3","key":"e_1_2_14_66_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2133.2008.09008.x","article-title":"How not to get scar (r) ed: pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia","volume":"160","author":"Harries M","year":"2009","journal-title":"Br J Dermatol"},{"issue":"2","key":"e_1_2_14_67_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/path.4233","article-title":"Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche","volume":"231","author":"Harries MJ","year":"2013","journal-title":"J Pathol"},{"issue":"1","key":"e_1_2_14_68_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1067\/mjd.2003.68","article-title":"Summary of North American Hair Research Society (NAHRS)\u2010sponsored workshop on cicatricial alopecia, Duke university medical center, February 10 and 11, 2001","volume":"48","author":"Olsen EA","year":"2003","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"e_1_2_14_69_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2133.2008.08591.x","article-title":"Management of primary cicatricial alopecias: options for treatment","volume":"159","author":"Harries M","year":"2008","journal-title":"Br J Dermatol"},{"issue":"4","key":"e_1_2_14_70_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/ddg.13498","article-title":"Cicatricial alopecia","volume":"16","author":"Kanti V","year":"2018","journal-title":"J Dtsch Dermatol Ges"},{"issue":"5","key":"e_1_2_14_71_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000496708","article-title":"Frequency of the types of alopecia at twenty\u2010two specialist hair clinics: a multicenter study","volume":"5","author":"Va\u00f1\u00f3\u2010Galv\u00e1n S","year":"2019","journal-title":"Skin Appendage Disord"},{"issue":"8","key":"e_1_2_14_72_1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1001\/jamadermatol.2020.1287","article-title":"Dermatoscopic evaluation of central centrifugal cicatricial alopecia beyond the vertex scalp","volume":"156","author":"Felix K","year":"2020","journal-title":"JAMA Dermatol"},{"issue":"5","key":"e_1_2_14_73_1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.jaad.2018.05.1257","article-title":"Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia","volume":"79","author":"Aguh C","year":"2018","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"e_1_2_14_74_1","doi-asserted-by":"crossref","DOI":"10.1111\/1346-8138.15595","article-title":"Comorbid anxiety and depression among black women with central centrifugal cicatricial alopecia: A retrospective study","volume":"48","author":"McKenzie SA","year":"2021","journal-title":"J Dermatol"},{"issue":"5","key":"e_1_2_14_75_1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/j.1365-2133.2012.11050.x","article-title":"Traction: risk factor or coincidence in central centrifugal cicatricial alopecia?","volume":"167","author":"Khumalo N","year":"2012","journal-title":"Br J Dermatol"},{"issue":"12","key":"e_1_2_14_76_1","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/j.1365-4632.2012.05621.x","article-title":"Prospective histologic examinations in patients who practice traumatic hairstyling","volume":"52","author":"Uhlenhake EE","year":"2013","journal-title":"Int J Dermatol"},{"issue":"4","key":"e_1_2_14_77_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jaad.2013.11.035","article-title":"Autosomal dominant inheritance of central centrifugal\u00e1cicatricial alopecia in black South Africans","volume":"70","author":"Dlova NC","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_14_78_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-4632.2012.05557.x","article-title":"Central centrifugal cicatricial alopecia: possible familial aetiology in two African families from South Africa","volume":"51","author":"Dlova NC","year":"2012","journal-title":"Int J Dermatol"},{"issue":"6","key":"e_1_2_14_79_1","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1111\/ijd.13061","article-title":"Factors affecting the severity of central centrifugal cicatricial alopecia","volume":"55","author":"Suchonwanit P","year":"2016","journal-title":"Int J Dermatol"},{"issue":"1","key":"e_1_2_14_80_1","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2025.2543517","article-title":"Advances in the extracellular vesicles treatment of alopecia","volume":"57","author":"Wu X","year":"2025","journal-title":"Ann Med"},{"issue":"5","key":"e_1_2_14_81_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/14656566.2020.1721463","article-title":"A review of the treatment of male pattern hair loss","volume":"21","author":"York K","year":"2020","journal-title":"Expert Opin Pharmacother"},{"issue":"1","key":"e_1_2_14_82_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/jdv.14624","article-title":"Evidence\u2010based (S3) guideline for the treatment of androgenetic alopecia in women and in men\u2013short version","volume":"32","author":"Kanti V","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"7","key":"e_1_2_14_83_1","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1111\/jdv.17216","article-title":"Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose","volume":"35","author":"Villani A","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"3","key":"e_1_2_14_84_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1468-3083.2003.00621.x","article-title":"Hypertrichosis in females applying minoxidil topical solution and in normal controls","volume":"17","author":"Dawber R","year":"2003","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"e_1_2_14_85_1","first-page":"12","article-title":"Adverse sexual effects of treatment with finasteride or dutasteride for male androgenetic alopecia: a systematic review and meta\u2010analysis","volume":"99","author":"Lee S","year":"2019","journal-title":"Acta Derm Venereol"},{"issue":"6","key":"e_1_2_14_86_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/MED.0000000000000112","article-title":"5\u03b1\u2010Reductase inhibitors in androgenetic alopecia","volume":"21","author":"Yim E","year":"2014","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"1","key":"e_1_2_14_87_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00266-019-01529-9","article-title":"Contemporary management of alopecia: a systematic review and meta\u2010analysis for surgeons","volume":"44","author":"Stoneburner J","year":"2020","journal-title":"Aesth Plast Surg"},{"key":"e_1_2_14_88_1","first-page":"161","volume-title":"Techniques for Hair Restoration, An Issue of Facial Plastic Surgery Clinics of North America E\u2010Book","author":"Sand JP","year":"2020"},{"issue":"2","key":"e_1_2_14_89_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.fsc.2020.01.006","article-title":"Follicular Unit Excision: Current Practice and Future Developments","volume":"28","author":"Epstein GK","year":"2020","journal-title":"Facial Plast Surg Clin North Am"},{"issue":"4","key":"e_1_2_14_90_1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jaad.2021.03.124","article-title":"Hair transplantation: basic overview","volume":"85","author":"Jimenez F","year":"2021","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"e_1_2_14_91_1","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1097\/DSS.0000000000002373","article-title":"Old friend or new ally: a comparison of follicular unit transplantation and follicular unit excision methods in hair transplantation","volume":"46","author":"Gupta AK","year":"2020","journal-title":"Dermatologic Surg"},{"issue":"3","key":"e_1_2_14_92_1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jaad.2018.09.033","article-title":"Treatment of male pattern alopecia with platelet\u2010rich plasma: a double\u2010blind controlled study with analysis of platelet number and growth factor levels","volume":"80","author":"Rodrigues BL","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_14_93_1","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.2147\/CCID.S528663","article-title":"Effectiveness of Autologous Platelet\u2010Rich Plasma for Androgenetic Alopecia: A Double\u2010Center, Non\u2010Controlled, Randomized Clinical Study in Vietnam","volume":"18","author":"Nguyen LV","year":"2025","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"1","key":"e_1_2_14_94_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/DSS.0000000000001651","article-title":"Platelet\u2010rich plasma therapy for male and female pattern hair loss","volume":"45","author":"Avram MR","year":"2019","journal-title":"Dermatologic Surg"},{"key":"e_1_2_14_95_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/09546634.2018.1528327","article-title":"Shedding light on the FDA's 510 (k) approvals process: low\u2010level laser therapy devices used in the treatment of androgenetic alopecia","volume":"30","author":"Wang S","year":"2019","journal-title":"J Dermatol Treat"},{"issue":"4","key":"e_1_2_14_96_1","first-page":"457","article-title":"A systematic review of topical finasteride in the treatment of androgenetic alopecia in men and women","volume":"17","author":"Lee SW","year":"2018","journal-title":"J Drugs Dermatol"},{"issue":"1","key":"e_1_2_14_97_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0190-9622(87)70179-0","article-title":"Topical minoxidil in male pattern baldness: effects of discontinuation of treatment","volume":"17","author":"Olsen EA","year":"1987","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"e_1_2_14_98_1","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s13555-025-01421-2","article-title":"Local corticosteroids for alopecia areata: A narrative review","volume":"15","author":"Gregoire S","year":"2025","journal-title":"Dermatol Ther"},{"issue":"1","key":"e_1_2_14_99_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4103\/0974-7753.66920","article-title":"Intralesional steroids for alopecia areata","volume":"2","author":"Kumaresan M","year":"2010","journal-title":"Int J Trichology"},{"issue":"1","key":"e_1_2_14_100_1","doi-asserted-by":"crossref","DOI":"10.1155\/dth\/6621458","article-title":"Long\u2010Term Efficacy and Safety of Low\u2010Level Laser Therapy for Androgenetic Alopecia: A 12\u2010Month Prospective Trial","volume":"2026","author":"Shin J\u2010W","year":"2026","journal-title":"Dermatol Ther"},{"key":"e_1_2_14_101_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.843127","article-title":"Treatment of androgenetic alopecia using PRP to target dysregulated mechanisms and pathways","volume":"9","author":"Abdin R","year":"2022","journal-title":"Front Med"},{"issue":"11","key":"e_1_2_14_102_1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.5966\/sctm.2015-0107","article-title":"The effect of platelet\u2010rich plasma in hair regrowth: a randomized placebo\u2010controlled trial","volume":"4","author":"Gentile P","year":"2015","journal-title":"Stem Cells Transl Med"},{"issue":"4","key":"e_1_2_14_103_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/JCAS.JCAS_44_20","article-title":"Longevity of hair follicles after follicular unit transplant surgery","volume":"13","author":"Kumaresan M","year":"2020","journal-title":"J Cutan Aesthet Surg"},{"issue":"2","key":"e_1_2_14_104_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jaad.2021.08.043","article-title":"Development of the alopecia areata scale for clinical use: results of an academic\u2013industry collaborative effort","volume":"86","author":"King BA","year":"2022","journal-title":"J Am Acad Dermatol"},{"issue":"14","key":"e_1_2_14_105_1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s40265-016-0629-5","article-title":"Androgenetic alopecia: an update of treatment options","volume":"76","author":"Kelly Y","year":"2016","journal-title":"Drugs"},{"issue":"1","key":"e_1_2_14_106_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2220\/biomedres.31.27","article-title":"Hair growth stimulated by conditioned medium of adipose\u2010derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion","volume":"31","author":"Park B\u2010S","year":"2010","journal-title":"Biomed Res"},{"issue":"7","key":"e_1_2_14_107_1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.2174\/1574888X12666170504120244","article-title":"Up\u2010to\u2010date clinical trials of hair regeneration using conditioned media of adipose\u2010derived stem cells in male and female pattern hair loss","volume":"12","author":"Shin H","year":"2017","journal-title":"Curr Stem Cell Res Ther"},{"issue":"5","key":"e_1_2_14_108_1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.cell.2011.07.019","article-title":"Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling","volume":"146","author":"Festa E","year":"2011","journal-title":"Cell"},{"issue":"4","key":"e_1_2_14_109_1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.4252\/wjsc.v7.i4.711","article-title":"Epidermal stem cells and skin tissue engineering in hair follicle regeneration","volume":"7","author":"Bala\u00f1\u00e1 ME","year":"2015","journal-title":"World J Stem Cells"},{"issue":"1","key":"e_1_2_14_110_1","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1038\/s41467-018-07579-y","article-title":"Tissue engineering of human hair follicles using a biomimetic developmental approach","volume":"9","author":"Abaci HE","year":"2018","journal-title":"Nat Commun"},{"issue":"7","key":"e_1_2_14_111_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA\u2010ScR): checklist and explanation","volume":"169","author":"Tricco AC","year":"2018","journal-title":"Ann Intern Med"},{"issue":"5","key":"e_1_2_14_112_1","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1111\/jocd.14846","article-title":"Effects of exosome from adipose\u2010derived stem cell on hair loss: A retrospective analysis of 39 patients","volume":"21","author":"Park BS","year":"2022","journal-title":"J Cosmet Dermatol"},{"key":"e_1_2_14_113_1","first-page":"1","article-title":"A prospective study of exosome therapy for androgenetic alopecia","volume":"49","author":"Wan J","year":"2025","journal-title":"Aesth Plast Surg"},{"issue":"9","key":"e_1_2_14_114_1","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/ijd.17406","article-title":"The efficacy of adipose stem cell\u2010derived exosomes in hair regeneration based on a preclinical and clinical study","volume":"63","author":"Lee E","year":"2024","journal-title":"Int J Dermatol"},{"issue":"3","key":"e_1_2_14_115_1","article-title":"Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia","volume":"17","author":"Fu Y","year":"2025","journal-title":"World J Stem Cells"},{"issue":"1","key":"e_1_2_14_116_1","article-title":"Adipose\u2010derived stem cell exosomes antagonize the inhibitory effect of dihydrotestosterone on hair follicle growth by activating Wnt\/\u03b2\u2010Catenin pathway","volume":"2023","author":"Tang X","year":"2023","journal-title":"Stem Cells Int"},{"issue":"6","key":"e_1_2_14_117_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065703","article-title":"Adipose mesenchymal stromal cell\u2010derived exosomes carrying MiR\u2010122\u20105p antagonize the inhibitory effect of dihydrotestosterone on hair follicles by targeting the TGF\u2010\u03b21\/SMAD3 signaling pathway","volume":"24","author":"Liang Y","year":"2023","journal-title":"Int J Mol Sci"},{"key":"e_1_2_14_118_1","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.jid.2025.03.042","article-title":"Mir\u2010574\u20103p and Mir\u2010125a\u20105p in Adipose Derived Mesenchymal Stem Cell Exosomes Synergistically Target TGF\u2010\u03b21\/Smad2 Signaling Pathway for the Treatment of Androgenic Alopecia","volume":"145","author":"Ma C","year":"2025","journal-title":"J Invest Dermatol"},{"issue":"5","key":"e_1_2_14_119_1","doi-asserted-by":"crossref","DOI":"10.4252\/wjsc.v17.i5.107078","article-title":"Potential of mesenchymal stem cell\u2010derived exosomes in the treatment of androgenetic alopecia","volume":"17","author":"Rajendran RL","year":"2025","journal-title":"World J Stem Cells"},{"issue":"1","key":"e_1_2_14_120_1","article-title":"Adipose Tissue\u2013Derived Exosomes as a Novel Therapeutic Approach for Refractory Alopecia Areata: A Report of Two Cases","volume":"2025","author":"Nilforoushzadeh MA","year":"2025","journal-title":"Case Rep Dermatol Med"},{"issue":"13","key":"e_1_2_14_121_1","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202500853R","article-title":"Single\u2010Cell RNA Sequencing Highlights a Contribution of Human Amniotic Mesenchymal Stem Cells\u2010Derived Exosomes to Androgenetic Alopecia","volume":"39","author":"Wang XY","year":"2025","journal-title":"FASEB J"},{"issue":"14","key":"e_1_2_14_122_1","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.7150\/thno.107659","article-title":"Enhancing hair regrowth using rapamycin\u2010primed mesenchymal stem cell\u2010derived exosomes","volume":"15","author":"Shrestha M","year":"2025","journal-title":"Theranostics"},{"issue":"5","key":"e_1_2_14_123_1","first-page":"576","article-title":"Effects of adipose\u2010derived stem cells and platelet\u2010rich plasma exosomes on the inductivity of hair dermal papilla cells","volume":"23","author":"Nilforoushzadeh MA","year":"2021","journal-title":"Cell J (Yakhteh)"},{"issue":"4","key":"e_1_2_14_124_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s13770-021-00347-y","article-title":"Adipose\u2010derived stem cell exosomes promoted hair regeneration","volume":"18","author":"Wu J","year":"2021","journal-title":"Tissue Eng Regener Med"},{"issue":"1","key":"e_1_2_14_125_1","article-title":"Exosomes secreted from adipose\u2010derived stem cells are a potential treatment agent for immune\u2010mediated alopecia","volume":"2022","author":"Li Y","year":"2022","journal-title":"J Immunol Res"},{"issue":"19","key":"e_1_2_14_126_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202200908","article-title":"A drug\u2010free, hair follicle cycling regulatable, separable, antibacterial microneedle patch for hair regeneration therapy","volume":"11","author":"Shi Y","year":"2022","journal-title":"Adv Healthc Mater"},{"issue":"5","key":"e_1_2_14_127_1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1515\/jtim-2024-0012","article-title":"Exosomes derived from Umbilical cord mesenchymal stem cell promote hair regrowth in C57BL6 mice through upregulation of the RAS\/ERK signaling pathway","volume":"12","author":"Mao Y","year":"2024","journal-title":"J TRANSL INTERN MED"},{"issue":"4","key":"e_1_2_14_128_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0320154","article-title":"Exosomes from human umbilical cord mesenchymal stem cells promote the growth of human hair dermal papilla cells","volume":"20","author":"Chen Y\u2010C","year":"2025","journal-title":"PLoS One"},{"issue":"2","key":"e_1_2_14_129_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/cbin.12099","article-title":"Exosomes derived from uMSCs promote hair regrowth in alopecia areata through accelerating human hair follicular keratinocyte proliferation and migration","volume":"48","author":"Hu S","year":"2024","journal-title":"Cell Biol Int"},{"issue":"5","key":"e_1_2_14_130_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2024.152184","article-title":"Stimulation of mouse hair regrowth by exosomes derived from human umbilical cord mesenchymal stem cells","volume":"126","author":"Jiao Y","year":"2024","journal-title":"Acta Histochem"},{"key":"e_1_2_14_131_1","doi-asserted-by":"crossref","DOI":"10.1093\/asjof\/ojac045","article-title":"Clinical use of extracellular vesicles in the management of male and female pattern hair loss: a preliminary retrospective institutional review board safety and efficacy study","volume":"4","author":"Sasaki GH","year":"2022","journal-title":"Aesthet Surg J Open Forum"},{"issue":"1","key":"e_1_2_14_132_1","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1038\/s41598-017-15505-3","article-title":"Extracellular vesicles derived from MSCs activates dermal papilla cell in\u00a0vitro and promotes hair follicle conversion from telogen to anagen in mice","volume":"7","author":"Rajendran RL","year":"2017","journal-title":"Sci Rep"},{"issue":"4","key":"e_1_2_14_133_1","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1021\/acsnano.8b09573","article-title":"A therapeutic microneedle patch made from hair\u2010derived keratin for promoting hair regrowth","volume":"13","author":"Yang G","year":"2019","journal-title":"ACS Nano"},{"issue":"4","key":"e_1_2_14_134_1","doi-asserted-by":"crossref","first-page":"e15165","DOI":"10.1016\/j.heliyon.2023.e15165","article-title":"Treatment of persistent chemotherapy\u2010induced hair loss (Alopecia) with human mesenchymal stromal cells exosome enriched extracellular vesicles: A case report","volume":"9","author":"Norooznezhad AH","year":"2023","journal-title":"Heliyon"},{"key":"e_1_2_14_135_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00266-024-04332-3","article-title":"Effectiveness of exosome treatment in androgenetic alopecia: outcomes of a prospective study","volume":"48","author":"Ersan M","year":"2024","journal-title":"Aesth Plast Surg"},{"key":"e_1_2_14_136_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.685873","article-title":"Human amniotic fluid stem cell\u2010derived exosomes as a novel cell\u2010free therapy for cutaneous regeneration","volume":"9","author":"Zhang Y","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"e_1_2_14_137_1","first-page":"626","article-title":"Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair","volume":"19","author":"Ma L","year":"2023","journal-title":"Bioact Mater"},{"issue":"23","key":"e_1_2_14_138_1","doi-asserted-by":"crossref","first-page":"15010","DOI":"10.3390\/ijms232315010","article-title":"Bio\u2010pulsed stimulation effectively improves the production of avian mesenchymal stem cell\u2010derived extracellular vesicles that enhance the bioactivity of skin fibroblasts and hair follicle cells","volume":"23","author":"Shieh J\u2010S","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"7","key":"e_1_2_14_139_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3390\/cimb47070539","article-title":"Topical Application of Bio\u2010Pulsed Avian MSC\u2010Derived Extracellular Vesicles Enhances Hair Regrowth and Skin Rejuvenation: Evidence from Clinical Evaluation and miRNA Profiling","volume":"47","author":"Shieh J\u2010S","year":"2025","journal-title":"Curr Issues Mol Biol"},{"issue":"7","key":"e_1_2_14_140_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4252\/wjsc.v14.i7.527","article-title":"Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles","volume":"14","author":"Rajendran RL","year":"2022","journal-title":"World J Stem Cells"},{"issue":"4","key":"e_1_2_14_141_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2019.06.256","article-title":"Exosome for hair regeneration: from bench to bedside","volume":"81","author":"Huh C\u2010H","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"e_1_2_14_142_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1186\/s12951-024-02689-w","article-title":"Exosomes derived from mouse vibrissa dermal papilla cells promote hair follicle regeneration during wound healing by activating Wnt\/\u03b2\u2010catenin signaling pathway","volume":"22","author":"Shang Y","year":"2024","journal-title":"J Nanobiotechnol"},{"issue":"4","key":"e_1_2_14_143_1","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.3390\/ijms24043961","article-title":"Dermal papillacell\u2010derived exosomes regulate hair follicle stem cell proliferation via LEF1","volume":"24","author":"Li J","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"e_1_2_14_144_1","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9042345","article-title":"Exosomes derived from dermal papilla cells mediate hair follicle stem cell proliferation through the Wnt3a\/\u03b2\u2010catenin signaling pathway","volume":"2022","author":"Li J","year":"2022","journal-title":"Oxidative Med Cell Longev"},{"key":"e_1_2_14_145_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijbiomac.2022.02.177","article-title":"Exosomal miRNA\u2010181a\u20105p from the cells of the hair follicle dermal papilla promotes the hair follicle growth and development via the Wnt\/\u03b2\u2010catenin signaling pathway","volume":"207","author":"Zhao B","year":"2022","journal-title":"Int J Biol Macromol"},{"issue":"30","key":"e_1_2_14_146_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1685","article-title":"Dermal exosomes containing miR\u2010218\u20105p promote hair regeneration by regulating \u03b2\u2010catenin signaling","volume":"6","author":"Hu S","year":"2020","journal-title":"Sci Adv"},{"issue":"11","key":"e_1_2_14_147_1","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1111\/jocd.15890","article-title":"Treatment of androgenetic alopecia by exosomes secreted from hair papilla cells and the intervention effect of LTF","volume":"22","author":"Wang G","year":"2023","journal-title":"J Cosmet Dermatol"},{"key":"e_1_2_14_148_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.139292","article-title":"Decorin\u2010mediated dermal papilla cell\u2010derived exosomes regulate hair follicle growth and development through miR\u2010129\u20102\u20103p\/SMAD3\/TGF\u2010\u03b2 axis","volume":"295","author":"Li J","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"e_1_2_14_149_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.593638","article-title":"miR\u2010140\u20105p in small extracellular vesicles from human papilla cells stimulates hair growth by promoting proliferation of outer root sheath and hair matrix cells","volume":"8","author":"Chen Y","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"e_1_2_14_150_1","doi-asserted-by":"crossref","DOI":"10.3390\/cells11020202","article-title":"Dermal papilla cell\u2010derived extracellular vesicles increase hair inductive gene expression in adipose stem cells via \u03b2\u2010catenin activation","volume":"11","author":"Kazi T","year":"2022","journal-title":"Cells"},{"issue":"2","key":"e_1_2_14_151_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bbrc.2018.04.067","article-title":"Regulation of hair follicle development by exosomes derived from dermal papilla cells","volume":"500","author":"Zhou L","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"e_1_2_14_152_1","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/exd.13927","article-title":"Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair\u2010inductive capacity of cultured dermal papilla spheres","volume":"28","author":"Kwack MH","year":"2019","journal-title":"Exp Dermatol"},{"issue":"7","key":"e_1_2_14_153_1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3390\/pharmaceutics16070935","article-title":"Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment","volume":"16","author":"Zhang H","year":"2024","journal-title":"Pharmaceutics"},{"issue":"7","key":"e_1_2_14_154_1","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.7150\/ijbs.33233","article-title":"Exosomal micro RNAs derived from dermal papilla cells mediate hair follicle stem cell proliferation and differentiation","volume":"15","author":"Yan H","year":"2019","journal-title":"Int J Biol Sci"},{"issue":"3","key":"e_1_2_14_155_1","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.7150\/thno.39566","article-title":"Sustained release of dermal papilla\u2010derived extracellular vesicles from injectable microgel promotes hair growth","volume":"10","author":"Chen Y","year":"2020","journal-title":"Theranostics"},{"issue":"2","key":"e_1_2_14_156_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/wrr.12989","article-title":"Photobiomodulation promotes hair regeneration in injured skin by enhancing migration and exosome secretion of dermal papilla cells","volume":"30","author":"Zhang Y","year":"2022","journal-title":"Wound Repair Regen"},{"issue":"1","key":"e_1_2_14_157_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-022-03051-3","article-title":"Ficoll density gradient sedimentation isolation of pelage hair follicle mesenchymal stem cells from adult mouse back skin: a novel method for hair follicle mesenchymal stem cells isolation","volume":"13","author":"Gan Y","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"e_1_2_14_158_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114483","article-title":"Novel strategy for hair regeneration: Exosomes and collagenous sequences of human a1 (XVII) chain enhance hair follicle stem cell activity by regulating the hsa\u2010novel\u2010238a\u2010CASP9 axis","volume":"446","author":"Zhao J","year":"2025","journal-title":"Exp Cell Res"},{"key":"e_1_2_14_159_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbd.2024.101357","article-title":"Exosomes serve as a crucial mediator of epithelial\u2013fibroblast communication during hair follicle morphogenesis in cashmere goats","volume":"52","author":"Hai E","year":"2024","journal-title":"Comp Biochem Physiol D Genomics Proteomics"},{"issue":"7","key":"e_1_2_14_160_1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/1873-3468.14050","article-title":"Human fibroblast\u2010derived extracellular vesicles promote hair growth in cultured human hair follicles","volume":"595","author":"Rajendran RL","year":"2021","journal-title":"FEBS Lett"},{"issue":"9","key":"e_1_2_14_161_1","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/stem.3043","article-title":"Extracellular vesicles from activated dermal fibroblasts stimulate hair follicle growth through dermal papilla\u2010secreted norrin","volume":"37","author":"Riche A","year":"2019","journal-title":"Stem Cells"},{"issue":"1","key":"e_1_2_14_162_1","doi-asserted-by":"crossref","DOI":"10.1111\/exd.14948","article-title":"Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells","volume":"33","author":"Liu F","year":"2024","journal-title":"Exp Dermatol"},{"key":"e_1_2_14_163_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s13770-020-00266-4","article-title":"Human hair outer root sheath cells and platelet\u2010lysis exosomes promote hair inductivity of dermal papilla cell","volume":"17","author":"Nilforoushzadeh MA","year":"2020","journal-title":"Tissue Eng Regener Med"},{"issue":"6","key":"e_1_2_14_164_1","doi-asserted-by":"crossref","DOI":"10.3390\/nu13062087","article-title":"Exosomes derived from fisetin\u2010treated keratinocytes mediate hair growth promotion","volume":"13","author":"Ogawa M","year":"2021","journal-title":"Nutrients"},{"key":"e_1_2_14_165_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.reth.2025.04.003","article-title":"Platelet\u2010rich plasma\u2010derived exosomes stimulate hair follicle growth through activation of the Wnt\/\u03b2\u2010Catenin signaling pathway","volume":"29","author":"Lu C","year":"2025","journal-title":"Regen Ther"},{"issue":"1","key":"e_1_2_14_166_1","doi-asserted-by":"crossref","DOI":"10.1080\/09537104.2025.2498353","article-title":"Platelet\u2010derived extracellular vesicles promote hair follicle growth through \u03b2\u2010catenin signaling pathway","volume":"36","author":"Wang L","year":"2025","journal-title":"Platelets"},{"issue":"2","key":"e_1_2_14_167_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.22159\/ijap.2025.v17s2.13","article-title":"COMPARATIVE STUDY ON THERAPEUTIC EFFICACY OF MINOXIDIL AND PLATELET\u2010RICH PLASMA EXOSOME IN ANDROGENETIC ALOPECIA MICE MODELS","volume":"17","author":"Mulianto N","year":"2025","journal-title":"Int J Appl Pharm"},{"issue":"5","key":"e_1_2_14_168_1","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70080","article-title":"Erythrocyte Extracellular Vesicles Amalgamate into the Hair and Skin to Maintain Homeostasis","volume":"14","author":"Cao Z","year":"2025","journal-title":"J Extracell Vesicles"},{"issue":"4","key":"e_1_2_14_169_1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/cells9040856","article-title":"Macrophage\u2010derived extracellular vesicle promotes hair growth","volume":"9","author":"Rajendran RL","year":"2020","journal-title":"Cells"},{"issue":"1","key":"e_1_2_14_170_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112887","article-title":"Engineered extracellular vesicle mimetics from macrophage promotes hair growth in mice and promotes human hair follicle growth","volume":"409","author":"Rajendran RL","year":"2021","journal-title":"Exp Cell Res"},{"key":"e_1_2_14_171_1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3389\/fimmu.2018.01279","article-title":"Immunoregulatory effects of myeloid\u2010derived suppressor cell exosomes in mouse model of autoimmune alopecia areata","volume":"9","author":"Z\u00f6ller M","year":"2018","journal-title":"Front Immunol"},{"key":"e_1_2_14_172_1","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1614090","article-title":"Subcutaneous injection of genetically engineered exosomes for androgenic alopecia treatment","volume":"13","author":"Liu Y","year":"2025","journal-title":"Front Bioeng Biotechnol"},{"key":"e_1_2_14_173_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113597","article-title":"Microneedle\u2010mediated hypoxic extracellular vesicle\u2010encapsulated selenium nanoparticles delivery to treat androgenetic alopecia","volume":"381","author":"Jing S","year":"2025","journal-title":"J Control Release"},{"issue":"1","key":"e_1_2_14_174_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00266-024-04439-7","article-title":"Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In\u00a0Vitro and In\u00a0Vivo Analysis Through a Multicentric, Observational, Evaluator\u2010Blinded Study","volume":"49","author":"Gentile P","year":"2025","journal-title":"Aesth Plast Surg"},{"issue":"6","key":"e_1_2_14_175_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3390\/cosmetics12060253","article-title":"Centella asiatica L. Urb. Extracellular Vesicle and Growth Factor Essence for Hair and Scalp Health: A 56\u2010Day Exploratory Randomized Trial","volume":"12","author":"Chang T\u2010M","year":"2025","journal-title":"Cosmetics"},{"issue":"3","key":"e_1_2_14_176_1","doi-asserted-by":"crossref","DOI":"10.3390\/life15030500","article-title":"A pilot randomized controlled trial (RCT) evaluating the efficacy of an exosome\u2010containing plant extract formulation for treating male alopecia","volume":"15","author":"Amini F","year":"2025","journal-title":"Life"},{"issue":"7","key":"e_1_2_14_177_1","article-title":"Garlic exosomes promote hair growth through the wnt\/\u03b2\u2010catenin pathway and growth factors","volume":"15","author":"Yuksel EI","year":"2023","journal-title":"Cureus"},{"issue":"2","key":"e_1_2_14_178_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3390\/cimb44020058","article-title":"Stimulatory effects of extracellular vesicles derived from Leuconostoc holzapfelii that exists in human scalp on hair growth in human follicle dermal papilla cells","volume":"44","author":"Yoon YC","year":"2022","journal-title":"Curr Issues Mol Biol"},{"key":"e_1_2_14_179_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.815205","article-title":"Potential of colostrum\u2010derived exosomes for promoting hair regeneration through the transition from telogen to anagen phase","volume":"10","author":"Kim H","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"e_1_2_14_180_1","article-title":"Curcumin\u2010primed milk\u2010derived extracellular vesicles remodel hair follicle microenvironment for the treatment of androgenetic alopecia. Regenerative","volume":"12","author":"Hou C","year":"2025","journal-title":"Biomaterials"},{"key":"e_1_2_14_181_1","doi-asserted-by":"crossref","DOI":"10.3389\/fanim.2025.1562392","article-title":"Alteration of hair growth in mice by circulating exosomes from Xinji fine\u2010wool and small\u2010tailed Han sheep","volume":"6","author":"Zhang X","year":"2025","journal-title":"Front Anim Sci"},{"issue":"3","key":"e_1_2_14_182_1","doi-asserted-by":"crossref","DOI":"10.3390\/cosmetics12030097","article-title":"Successful Treatment of Hair Loss and Restoration of Natural Hair Color in Patient with Alopecia Areata Due to Psychological Disorder Using Exosomes: Case Report with 6\u2010Month Follow\u2010Up","volume":"12","author":"Bento EB","year":"2025","journal-title":"Cosmetics"},{"issue":"3","key":"e_1_2_14_183_1","doi-asserted-by":"crossref","DOI":"10.1111\/jocd.70115","article-title":"Achieving Sustained Hair Repigmentation in Poliosis Circumscripta: Retreatment Outcomes Using Exosomes and Fractional Picosecond Laser","volume":"24","author":"Lueangarun S","year":"2025","journal-title":"J Cosmet Dermatol"},{"issue":"6","key":"e_1_2_14_184_1","doi-asserted-by":"crossref","DOI":"10.1111\/jocd.70270","article-title":"Enhancing Hair Regrowth in Pediatric Morphea en Coup de Sabre by Fractional CO2 Laser\u2010Assisted Exosome Delivery","volume":"24","author":"Ahuja R","year":"2025","journal-title":"J Cosmet Dermatol"},{"issue":"11","key":"e_1_2_14_185_1","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1111\/jocd.16463","article-title":"Rose stem cell\u2010derived exosomes for hair regeneration enhancement via noninvasive electroporation in androgenetic alopecia","volume":"23","author":"Lueangarun S","year":"2024","journal-title":"J Cosmet Dermatol"},{"issue":"6","key":"e_1_2_14_186_1","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1111\/jocd.16261","article-title":"Hair repigmentation of poliosis circumscripta in androgenetic alopecia patient treated with exosomes and fractional picosecond laser","volume":"23","author":"Lueangarun S","year":"2024","journal-title":"J Cosmet Dermatol"},{"issue":"11","key":"e_1_2_14_187_1","doi-asserted-by":"crossref","DOI":"10.1111\/jocd.70526","article-title":"Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross\u2010Sectional Observational Study","volume":"24","author":"Lueangarun S","year":"2025","journal-title":"J Cosmet Dermatol"},{"issue":"1","key":"e_1_2_14_188_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13287-020-01723-6","article-title":"Human bone marrow mesenchymal stem cell\u2010derived exosomes stimulate cutaneous wound healing mediates through TGF\u2010\u03b2\/Smad signaling pathway","volume":"11","author":"Jiang T","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"e_1_2_14_189_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.stem.2011.11.005","article-title":"Paracrine TGF\u2010\u03b2 signaling counterbalances BMP\u2010mediated repression in hair follicle stem cell activation","volume":"10","author":"Oshimori N","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"2","key":"e_1_2_14_190_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/wrr.12398","article-title":"Transforming growth factor beta (TGF\u2010\u03b2) isoforms in wound healing and fibrosis","volume":"24","author":"Lichtman MK","year":"2016","journal-title":"Wound Repair Regen"},{"key":"e_1_2_14_191_1","first-page":"5373","article-title":"Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF\u20101, and TGF\u2010\u03b21 expression","volume":"9","author":"Hou C","year":"2015","journal-title":"Drug Des Devel Ther"},{"issue":"5","key":"e_1_2_14_192_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.stem.2014.09.009","article-title":"BMP signaling and its pSMAD1\/5 target genes differentially regulate hair follicle stem cell lineages","volume":"15","author":"Genander M","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"9","key":"e_1_2_14_193_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1432-0436.2004.07209005.x","article-title":"BMP signaling in the control of skin development and hair follicle growth","volume":"72","author":"Botchkarev VA","year":"2004","journal-title":"Differentiation"},{"issue":"7176","key":"e_1_2_14_194_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature06457","article-title":"Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration","volume":"451","author":"Plikus MV","year":"2008","journal-title":"Nature"},{"issue":"3","key":"e_1_2_14_195_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.35702\/Derm.10019","article-title":"Compare the efficacy of PRP intervention VS exosomes for hair loss, a case series study","volume":"4","author":"Hassan L","year":"2024","journal-title":"Dermis"},{"issue":"2","key":"e_1_2_14_196_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/DAD.0000000000001266","article-title":"Dickkopf\u20101 expression in androgenetic alopecia and alopecia areata in male patients","volume":"41","author":"Mahmoud EA","year":"2019","journal-title":"Am J Dermatopathol"},{"issue":"6","key":"e_1_2_14_197_1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1038\/jid.2013.42","article-title":"WIF1 is expressed by stem cells of the human interfollicular epidermis and acts to suppress keratinocyte proliferation","volume":"133","author":"Schl\u00fcter H","year":"2013","journal-title":"J Invest Dermatol"},{"issue":"11","key":"e_1_2_14_198_1","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.3390\/cells10112957","article-title":"Perspectives on miRNAs targeting DKK1 for developing hair regeneration therapy","volume":"10","author":"Papukashvili D","year":"2021","journal-title":"Cells"},{"issue":"2","key":"e_1_2_14_199_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2217\/rme-2022-0134","article-title":"Exosomes: the latest in regenerative aesthetics","volume":"18","author":"Vyas KS","year":"2023","journal-title":"Regen Med"},{"issue":"1","key":"e_1_2_14_200_1","doi-asserted-by":"crossref","DOI":"10.3390\/biom14010020","article-title":"Controlling hair loss by regulating apoptosis in hair follicles: A comprehensive overview","volume":"14","author":"Wang W","year":"2023","journal-title":"Biomolecules"},{"issue":"2","key":"e_1_2_14_201_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41409-019-0616-z","article-title":"Mesenchymal stem cell\u2010derived exosomes for clinical use","volume":"54","author":"Mendt M","year":"2019","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"e_1_2_14_202_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1159\/000510152","article-title":"Maintaining hair inductivity in human dermal papilla cells: a review of effective methods","volume":"33","author":"Taghiabadi E","year":"2020","journal-title":"Skin Pharmacol Physiol"},{"issue":"7","key":"e_1_2_14_203_1","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12458","article-title":"A systematic review and meta\u2010analysis of clinical trials assessing safety and efficacy of human extracellular vesicle\u2010based therapy","volume":"13","author":"Van Delen M","year":"2024","journal-title":"J Extracell Vesicles"},{"issue":"7","key":"e_1_2_14_204_1","doi-asserted-by":"crossref","DOI":"10.4252\/wjsc.v17.i7.108519","article-title":"Therapeutic potential of stem cell\u2010derived exosomes in hair regeneration: A systematic review","volume":"17","author":"Poddar N","year":"2025","journal-title":"World J Stem Cells"},{"key":"e_1_2_14_205_1","unstructured":"US Food and Drug Administration.Public Safety Notification on Exosome Products.2019https:\/\/www.fda.gov\/vaccines\u2010blood\u2010biologics\/safety\u2010availability\u2010biologics\/public\u2010safety\u2010notification\u2010exosome\u2010products"},{"issue":"2","key":"e_1_2_14_206_1","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1097\/SCS.0000000000009034","article-title":"Treatment of anaphylaxis after injection of stem cell exosomes with 5\u2010fluorouracil and triamcinolone acetonide","volume":"34","author":"Zhuang J","year":"2023","journal-title":"J Craniofac Surg"},{"issue":"10","key":"e_1_2_14_207_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2217\/rme-2023-0118","article-title":"Safety and efficacy claims made by US businesses marketing purported stem cell treatments and exosome therapies","volume":"18","author":"Turner L","year":"2023","journal-title":"Regen Med"}],"container-title":["Periodontology 2000"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.70057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/prd.70057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.70057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:34:51Z","timestamp":1785285291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/prd.70057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":206,"alternative-id":["10.1111\/prd.70057"],"URL":"https:\/\/doi.org\/10.1111\/prd.70057","archive":["Portico"],"relation":{},"ISSN":["0906-6713","1600-0757"],"issn-type":[{"value":"0906-6713","type":"print"},{"value":"1600-0757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"2026-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"prd.70057"}}