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Studies were categorized into: epidemiological, clinical, in\u00a0vivo, and in\u00a0vitro studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Osteoporosis and periodontal disease are inflammation\u2010associated conditions prevalent in the elderly that share common risk factors, molecular framework, and effects on periodontal breakdown and implant outcomes. Low bone mineral density is linked to increased periodontal destruction, notably in postmenopausal women. Osteoporotic individuals exhibit 1.13 to 2.63 increased odds of having periodontitis. Clinical studies show implant survival remains high in osteoporotic patients, though it is modestly reduced to 94%. Anti\u2010resorptive therapies protect against bone loss but are associated with the risk of osteonecrosis. In\u00a0vivo models reveal worsened periodontitis progression under osteoporotic conditions. Biologic agents, such as sclerostin\u2010neutralizing antibodies, are beneficial for disease management and bone regeneration in osteoporotic models. In\u00a0vitro research examining mechanisms of altered bone metabolism has identified potential therapeutic targets for bone diseases, such as human periodontal ligament\u2013derived mesenchymal stem cells and microbe\u2010associated molecular patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Osteoporosis may increase susceptibility for periodontitis and peri\u2010implant bone loss, though implant therapy and periodontal regeneration may still be possible through proper and interdisciplinary treatment planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Studies on the relationship between osteoporosis, periodontitis, and dental implant therapy emphasize the importance of integrative care. Risk factor identification and careful treatment planning are imperative to optimize clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.70062","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:17:25Z","timestamp":1785323845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shared molecular framework and bidirectional effects of osteoporosis on periodontal disease and dental implant therapy in the elderly"],"prefix":"10.1111","author":[{"given":"Samin","family":"Sirous","sequence":"first","affiliation":[{"name":"Section of Periodontics, School of Dentistry University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3586-082X","authenticated-orcid":false,"given":"Jaclyn C.","family":"Chalmers","sequence":"additional","affiliation":[{"name":"Section of Periodontics, School of Dentistry University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin\u2010Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Section of Periodontics, School of Dentistry University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumna","family":"Subhani","sequence":"additional","affiliation":[{"name":"Section of Periodontics, School of Dentistry University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-0654","authenticated-orcid":false,"given":"Yvonne L.","family":"Hernandez\u2010Kapila","sequence":"additional","affiliation":[{"name":"Section of Periodontics, School of Dentistry University of California Los Angeles  Los Angeles California USA"},{"name":"Section of Biosystems and Function, School of Dentistry University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Endotext","author":"Rosen CJ","year":"2000"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.882241"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-016-0330-3"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213380"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12422"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3437-y"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13531"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2007.tb00353.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18063321"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000272"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.b5927487"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05005-2"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.21409"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(22)00222-7"},{"issue":"9","key":"e_1_2_12_16_1","first-page":"1193","article-title":"The periodic health examination. 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