{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:04:13Z","timestamp":1789581853027,"version":"build-2803163510"},"reference-count":202,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aim<\/jats:title>\n                    <jats:p>Growing evidence suggests that imbalances occurring within the human microbiota and deregulation of the host immune response may play a significant role in the development of neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A comprehensive narrative review of the latest experimental, clinical, and epidemiological insights was conducted to explore the associations among oral dysbiosis, including periodontitis and peri\u2010implantitis, a low\u2010grade inflammatory phenotype, and biological pathways that may contribute to the onset of neuroinflammation and neuropathologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Periodontitis is a chronic inflammatory non\u2010communicable disease driven by subgingival dysbiosis, increasingly linked not only to progressive bone and tooth loss but also to a broad range of systemic chronic non\u2010communicable diseases. Indeed, the persistent burden of deregulated chronic inflammation not only exacerbates periodontal tissue destruction but also promotes a low\u2010grade inflammatory phenotype that may predispose patients to a spectrum of degenerative diseases, such as neurodegenerative disorders. In contrast, evidence regarding peri\u2010implantitis remains comparatively limited and indirect, although emerging data indicate potential systemic inflammatory and cognitive implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elucidating the intricate interactions between oral dysbiosis, periodontal diseases, chronic inflammation, and neurodegeneration is essential for understanding oral health's systemic implications for neurodegenerative and age\u2010related diseases. Current evidence supports an association between oral dysbiosis, chronic oral inflammation, and pathways relevant to neurodegeneration, particularly for periodontitis. However, important knowledge gaps remain, especially concerning peri\u2010implant diseases, where human data are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Effective management strategies targeting periodontal and peri\u2010implant dysbiosis and restoring the immune imbalance may offer novel avenues for promoting healthy aging and preventing neuropathic morbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.70075","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:40:16Z","timestamp":1789580416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From mouth to brain: Linking periodontal and peri\u2010implant dysbiosis to systemic inflammation and neuropathology"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-1382","authenticated-orcid":false,"given":"Emilio A.","family":"Cafferata","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Implantology and Oral Medicine Goethe Universit\u00e4t  Frankfurt am Main Germany"},{"name":"Oral Peri\u2010Implant Research Group, Department of Oral Implantology, Postgraduate School of Dentistry Universidad Cient\u00edfica del Sur  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-9903","authenticated-orcid":false,"given":"Frank","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Implantology and Oral Medicine Goethe Universit\u00e4t  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"D\u00edaz\u2010Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Universidad de Atacama  Copiap\u00f3 Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpdogan","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Department of Developmental and Surgical Sciences University of Minnesota School of Dental Medicine  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"Dewhirst FE","year":"2010","journal-title":"J Bacteriol"},{"key":"e_1_2_15_3_1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont RJ","year":"2018","journal-title":"Nat Rev 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