{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:23:37Z","timestamp":1787725417562,"version":"build-2784847793"},"reference-count":123,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peri\u2010implantitis is a biofilm\u2010associated inflammatory condition characterized by peri\u2010implant mucosal inflammation and progressive bone loss. The prevalence of peri\u2010implantitis continues to rise among patients with dental implants. Although peri\u2010implantitis and periodontitis share similar inflammatory phenotypes, histopathological studies have shown that peri\u2010implantitis lesions may exhibit larger inflammatory infiltrates compared with periodontal lesions. This pronounced local inflammatory response provides biological plausibility for potential systemic inflammatory effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To critically appraise the current evidence regarding the potential relationships of peri\u2010implantitis with systemic inflammation and systemic diseases, distinguish peri\u2010implantitis\u2010specific findings from extrapolations based on periodontitis research, and highlight the principal methodological limitations and priorities for future investigations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive narrative review of clinical studies, animal studies, and mechanistic studies exploring the relationships between peri\u2010implantitis, systemic inflammation, and systemic diseases was conducted. Evidence was synthesized according to local inflammatory characteristics, potential biological pathways linking peri\u2010implantitis to systemic effects, circulating inflammatory and metabolic alterations, and the methodological limitations of the available studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Some observational studies have reported elevated circulating inflammatory biomarkers, including C\u2010reactive protein and selected cytokines, in patients with peri\u2010implantitis. Limited interventional evidence also suggests that peri\u2010implantitis treatment may influence some systemic inflammatory markers. However, evidence regarding specific systemic diseases and underlying biological mechanisms remains sparse and is largely indirect or extrapolated from periodontitis research. Most available studies are cross\u2010sectional, involve small sample sizes, use heterogeneous methodologies, and provide limited control of confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Current evidence suggests that peri\u2010implantitis may be associated with systemic inflammatory changes. However, the available evidence is insufficient to establish causality or a clinically relevant systemic impact. Further adequately powered longitudinal, interventional, and mechanistic studies are needed to determine whether peri\u2010implantitis independently contributes to systemic inflammation or whether the observed associations reflect shared risk factors and inflammatory pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.70080","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:47:43Z","timestamp":1787723263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peri\u2010implantitis and systemic inflammation: Current evidence, biological plausibility, and research gaps"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3135-9943","authenticated-orcid":false,"given":"Yumeng","family":"Yan","sequence":"first","affiliation":[{"name":"Periodontology Unit UCL Eastman Dental Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-6235","authenticated-orcid":false,"given":"Jeanie","family":"Suvan","sequence":"additional","affiliation":[{"name":"Oral Sciences, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-935X","authenticated-orcid":false,"given":"Francesco","family":"D'Aiuto","sequence":"additional","affiliation":[{"name":"Oral Surgery Unit Imperial College Healthcare Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"issue":"21","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112906","article-title":"The role of inflammation in cardiovascular 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