{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:52:46Z","timestamp":1791899566654,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aim<\/jats:title>\n                    <jats:p>Peri\u2010implantitis represents a complex osteoimmune disorder characterized by dysregulated cellular ecosystems that drive chronic inflammation and accelerated peri\u2010implant bone loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This article was designed as a narrative scoping review to map and integrate the available evidence from transcriptomics, single\u2010cell RNA sequencing (scRNA\u2010seq), spatial transcriptomics, flow cytometry, and immunohistochemistry to construct a comprehensive cellular atlas of peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Findings<\/jats:title>\n                    <jats:p>\n                      Current evidence suggests that peri\u2010implantitis lesions contain expanded and activated neutrophil, macrophage, T\u2010cell, and B\u2010lineage compartments, together with stromal and vascular cell populations that may contribute to inflammatory amplification and osteoclastogenic signaling. Reported features include CXCR2\n                      <jats:sup>+<\/jats:sup>\n                      neutrophil subsets with NETosis\u2010associated activity, inflammatory macrophage states, altered Th17\/Treg\u2010related immune responses, and expanded B\u2010cell\/plasma\u2010cell compartments forming organized adaptive immune niches. Proposed molecular mechanisms include NF\u2010\u03baB\u2010related inflammatory activation, CXCL13\u2010associated adaptive immune organization, NETosis\u2010related pathways, and RANKL\u2010mediated osteoclastogenic signaling. However, several of these pathways remain incompletely validated in human peri\u2010implantitis tissue. Critical knowledge gaps include limited direct evidence for NLRP3 inflammasome activation, uncharacterized type I interferon signaling, unresolved hierarchies of cellular RANKL sources, and limited functional data for rare immune populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The peri\u2010implantitis osteoimmune microenvironment constitutes a highly organized, self\u2010reinforcing inflammatory ecosystem. Progress toward precision therapeutic strategies requires spatial multiomics at subcellular resolution, longitudinal human studies, and functional ex\u00a0vivo validation models to interrogate the self\u2010sustaining circuits identified here.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/prd.70095","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:26:33Z","timestamp":1791897993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The osteoimmune cell atlas of peri\u2010implantitis: A narrative scoping review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-1382","authenticated-orcid":false,"given":"Emilio A.","family":"Cafferata","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Implantology and Oral Medicine Goethe Universit\u00e4t  Frankfurt am Main Germany"},{"name":"Oral Peri\u2010Implant Research Group, Department of Oral Implantology, Postgraduate School of Dentistry Universidad Cient\u00edfica del Sur  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5477","authenticated-orcid":false,"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-9903","authenticated-orcid":false,"given":"Frank","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Implantology and Oral Medicine Goethe Universit\u00e4t  Frankfurt am Main 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