{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:30:58Z","timestamp":1778344258504,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,31]],"date-time":"2013-03-31T00:00:00Z","timestamp":1364688000000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Brain deformations might prevent clinical symptoms from worsening in patients with idiopathic normal pressure hydrocephalus (iNPH<\/jats:styled-content>). We investigated the relationship between reversibility of brain morphology after shunt operations and preoperative clinical symptoms in iNPH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Using head magnetic resonance images with voxel\u2010based morphometry, we measured the cerebrospinal fluid volume in the combined areas of the lateral and third ventricles and Sylvian fissure (the volume of the ventricles and S<\/jats:styled-content>ylvian fissure (vVS<\/jats:styled-content>)) and the volume of the subarachnoid space at high convexity and midline areas (vHCM<\/jats:styled-content>) before and 1 year after lumboperitoneal shunt operations in 12 patients with shunt\u2010responsive iNPH<\/jats:styled-content>. We used the ratio of normalized vVS<\/jats:styled-content> to normalized vHCM<\/jats:styled-content> (nvVS\/nvHCM<\/jats:styled-content>) as an index of the severity of the brain deformation. The degree of reversibility of the brain morphology after the shunt operation was defined as the change ratio of the preoperative nvVS\/nvHCM<\/jats:styled-content> to the postoperative nvVS\/nvHCM<\/jats:styled-content> (CR\u2010nvVS\/nvHCM<\/jats:styled-content>). Higher CR\u2010nvVS\/nvHCM<\/jats:styled-content> values indicated more improvement in the brain deformation. In addition, we rated the severity of the white matter lesions on the preoperative magnetic resonance images based on the F<\/jats:styled-content>azekas scale. Dependency in activities of daily living, gait and cognition were evaluated before and 1 year after the shunt operations.<\/jats:p><\/jats:sec>Results<\/jats:title>After the shunt operations, the nvVS\/nvHCM<\/jats:styled-content> and nvVS<\/jats:styled-content> decreased significantly, and nvHCM<\/jats:styled-content> increased significantly. The CR\u2010nvVS\/nvHCM<\/jats:styled-content> negatively correlated with the preoperative severity of dependency in activities of daily living, gait and cognitive impairments. The CR\u2010nvVS\/nvHCM<\/jats:styled-content> negatively correlated with the F<\/jats:styled-content>azekas scale, but not with age, duration of the disease and cerebrospinal fluid pressure.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Reversibility of brain morphology, which varied among iNPH<\/jats:styled-content> patients, would prevent clinical symptoms from worsening in iNPH<\/jats:styled-content> patients. The presence of white matter lesions reduced the degree of reversibility of the brain deformations in iNPH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12001","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T03:07:26Z","timestamp":1364785646000},"page":"41-48","source":"Crossref","is-referenced-by-count":13,"title":["Reversibility of brain morphology after shunt operations and preoperative clinical symptoms in patients with idiopathic normal pressure hydrocephalus"],"prefix":"10.1111","volume":"13","author":[{"given":"Tamiki","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine Suita Japan"},{"name":"Department of Psychiatry Osaka Police Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kazui","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuhiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Yoshiyama","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Division of Ultrahigh Field MRI, Institute for Biomedical Sciences Iwate Medical University Shiwa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Kishima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Yoshimine","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196507152730301"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-7-18"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.06.021"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.10.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.09.001"},{"key":"e_1_2_6_7_1","first-page":"1277","article-title":"CSF spaces in idiopathic normal pressure hydrocephalus: morphology and volumetry","volume":"19","author":"Kitagaki H","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0610-z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.604"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111149"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70447-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.22.2469"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0044509"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.096164"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688638908400940"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090510"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"8","author":"Ashburner J","year":"2007","journal-title":"Neuroimage"},{"key":"e_1_2_6_20_1","first-page":"915","article-title":"The morphologic correlate of incidental punctate white matter hyperintensities on MR images","volume":"12","author":"Fazekas F","year":"1991","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199703000-00011"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90139-3"},{"key":"e_1_2_6_23_1","first-page":"97","article-title":"Normal pressure hydrocephalus. Neuropathological study","volume":"37","author":"Akai K","year":"1987","journal-title":"Acta Pathol Jpn"}],"container-title":["Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpsyg.12001","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:04:59Z","timestamp":1698699899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyg.12001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/psyg.12001"],"URL":"https:\/\/doi.org\/10.1111\/psyg.12001","archive":["Portico"],"relation":{},"ISSN":["1346-3500","1479-8301"],"issn-type":[{"value":"1346-3500","type":"print"},{"value":"1479-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}