{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:34:57Z","timestamp":1790156097451,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>\n \n Dementia with\n L<\/jats:styled-content>\n ewy bodies (\n DLB<\/jats:styled-content>\n ) is defined pathologically as neurodegeneration associated with\n L<\/jats:styled-content>\n ewy bodies (\n LB<\/jats:styled-content>\n ).\n LB<\/jats:styled-content>\n \u2010related symptoms, including olfactory dysfunction, dysautonomia, and mood and sleep disorders, are increasingly recognized as clinical signs that enable the early detection of\n DLB<\/jats:styled-content>\n , because these symptoms often antedate dementia by years or even decades. It remains unknown if the clinical history of\n LB<\/jats:styled-content>\n \u2010related symptoms is sufficient for the prodromal state of\n DLB<\/jats:styled-content>\n to be suspected in memory clinics. We retrospectively investigated the clinical courses, including olfactory dysfunction, dysautonomia, depression, and rapid eye movement sleep behaviour disorder, of 90 patients with probable\n DLB<\/jats:styled-content>\n . The timing of\n LB<\/jats:styled-content>\n \u2010related symptoms that preceded or followed relative to the onset of memory loss was calculated.\n LB<\/jats:styled-content>\n \u2010related symptoms were present in 79 of 90 patients (87.8%) with probable\n DLB<\/jats:styled-content>\n before or at the time of memory loss onset. These symptoms preceded the onset of memory loss between 1.2 and 9.3 years. We also report on four non\u2010demented patients with a clinical history of\n LB<\/jats:styled-content>\n \u2010related symptoms in our memory clinic. All four patients showed reduced cardiac [\n 123<\/jats:sup>\n I<\/jats:styled-content>\n ]\u2010metaiodobenzylguanidine levels. Moreover, [\n 18<\/jats:sup>\n F<\/jats:styled-content>\n ]fluoro\u2010D\u2010glucose positron emission tomography scans revealed glucose hypometabolism in the occipital cortex in two patients. One patient converted to probable\n DLB<\/jats:styled-content>\n with the development of parkinsonism 2 years after major depression was diagnosed. Based on a clinical history of\n LB<\/jats:styled-content>\n \u2010related symptoms, we propose a conceptual framework to identify these symptomatic but non\u2010demented individuals that led us to suspect the underlying pathophysiology of\n L<\/jats:styled-content>\n ewy body disease. Further prospective study is warranted to determine the clinical significance of\n LB<\/jats:styled-content>\n \u2010related symptoms in non\u2010demented patients.\n <\/jats:p>","DOI":"10.1111\/psyg.12005","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T03:49:48Z","timestamp":1371008988000},"page":"128-138","source":"Crossref","is-referenced-by-count":98,"title":["Dementia with\n L<\/scp>\n ewy bodies: early diagnostic challenges"],"prefix":"10.1111","volume":"13","author":[{"given":"Hiroshige","family":"Fujishiro","sequence":"first","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical Center"},{"name":"Department of Psychiatry Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eizo","family":"Iseki","sequence":"additional","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical 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