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This study examined the effects of alcohol abstinence on cognitive decline in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cognitive function after alcohol abstinence was retrospectively reviewed in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients (high and low alcohol consumption groups) and then compared with an alcohol\u2010na\u00efve <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group. The alcohol\u2010na\u00efve <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group included 18 outpatients with no history of habitual drinking. The alcohol\u2010abstinence <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group included 20 outpatients who stopped drinking after their diagnoses. The latter group was classified into high and low groups depending on the amount of they drank before abstinence. Cognitive function was evaluated with the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ini\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ental <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tate <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>xamination at baseline, 6 months, and 12 months. For statistical analyses, a repeated measures, two\u2010factor <jats:sc>anova<\/jats:sc> and post\u2010hoc multiple comparisons were performed using the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>onferroni method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant effect of time on <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ini\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ental <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tate <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>xamination score, but there was no difference in the baseline scores of the alcohol\u2010na\u00efve and alcohol\u2010abstinence <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> groups. The score was significantly lower at 6 and 12 months than at baseline in the alcohol\u2010na\u00efve group, but no significant difference was seen in the alcohol\u2010abstinence group. There was a significant interaction between time and alcohol consumption subgroup on the score, with no difference in baseline score between the low and high consumption groups. The score was significantly lower only in the high consumption group at 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions\u2002<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>n <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients with a history of habitual drinking, abstinence was effective for reducing cognitive decline during the clinical course. However, such an effect was not seen in patients who had consumed high amounts of alcohol before diagnosis of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12008","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T07:49:48Z","timestamp":1371023388000},"page":"94-98","source":"Crossref","is-referenced-by-count":11,"title":["Changes in <scp>M<\/scp>ini\u2010<scp>M<\/scp>ental <scp>S<\/scp>tate <scp>E<\/scp>xamination score in <scp>A<\/scp>lzheimer's disease patients after stopping habitual drinking"],"prefix":"10.1111","volume":"13","author":[{"given":"Aiko","family":"Toda","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Science Graduate School of Medicine Juntendo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Tagata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and 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