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While L<\/jats:styled-content>\u2010dopa treatment is related to visual hallucinations, its relationship to mood fluctuation in DLB<\/jats:styled-content> is poorly understood. Herein, we report the improvement of behavioural and psychological symptoms of dementia through the adjustment of L<\/jats:styled-content>\u2010dopa treatment in a 78\u2010year\u2010old woman with probable DLB<\/jats:styled-content>. Her marked mood swings were improved by changing L<\/jats:styled-content>\u2010dopa administration from three to five times per day while maintaining the same total daily dosage. This observation suggests that there may be an association between plasmatic L<\/jats:styled-content>\u2010dopa levels and mood fluctuation in patients with DLB<\/jats:styled-content>. This pharmacological approach may be useful in the management of behavioural and psychological symptoms of dementia without the use of antipsychotic agents to avoid severe neuroleptic sensitivity, which is one of the suggestive clinical features in the T<\/jats:styled-content>hird C<\/jats:styled-content>onsortium on DLB<\/jats:styled-content> clinical criteria.<\/jats:p>","DOI":"10.1111\/psyg.12025","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T09:04:59Z","timestamp":1382951099000},"page":"250-253","source":"Crossref","is-referenced-by-count":2,"title":["Levodopa treatment and mood fluctuation in dementia with L<\/scp>ewy bodies: a case report"],"prefix":"10.1111","volume":"13","author":[{"given":"Hiroshige","family":"Fujishiro","sequence":"first","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical Center Juntendo University School of Medicine Tokyo Japan"},{"name":"Department of Psychiatry Juntendo Tokyo Koto Geriatric Medical Center Juntendo University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kasanuki","sequence":"additional","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical Center Juntendo University School of Medicine Tokyo Japan"},{"name":"Department of Psychiatry Juntendo Tokyo Koto Geriatric Medical Center Juntendo University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical Center Juntendo University School of Medicine Tokyo Japan"},{"name":"Department of Neurology Juntendo Tokyo Koto Geriatric Medical Center Juntendo University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,28]]},"reference":[{"issue":"11","key":"e_1_2_5_2_1","first-page":"5","article-title":"Behavioral and psychological symptoms in dementia: the role of atypical antipsychotic","volume":"65","author":"Lawlor BA","year":"2004","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.7.1039"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2007.00165.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31817d7a1d"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22322"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.052332"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05115.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.022"},{"key":"e_1_2_5_11_1","first-page":"653","article-title":"The progression of pathology in Parkinson's disease","volume":"16","author":"Halliday GM","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.09.036"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25048"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.09.023"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.9.1757"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21205"}],"container-title":["Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpsyg.12025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:46:36Z","timestamp":1696203996000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyg.12025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,28]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/psyg.12025"],"URL":"https:\/\/doi.org\/10.1111\/psyg.12025","archive":["Portico"],"relation":{},"ISSN":["1346-3500","1479-8301"],"issn-type":[{"value":"1346-3500","type":"print"},{"value":"1479-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,28]]}}}