{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:14:42Z","timestamp":1789622082676,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the fourth edition of the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>iagnostic and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tatistical <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>anual of <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ental <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isorders abandoned the use of the specifier \u2018late\u2010onset\u2019, a considerable number of studies have reported clinical characteristics of late\u2010onset schizophrenia. Still, only limited research has been conducted on late\u2010onset schizophrenia, especially in Asian countries. In this epidemiological study, the clinical characteristics of late\u2010onset schizophrenia were examined in comparison with early\u2010onset schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with schizophrenia admitted to the psychiatric ward of Jichi Medical University Hospital between 1 <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 1993 and 31 <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2006 were divided into two groups according to age at first onset: \u226540 years (late\u2010onset group) and &lt;40 years (early\u2010onset group). The sex ratio, presence or absence of depression, schizophrenia subtype, premorbid character, marital history, and employment history at first onset were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 316 patients with schizophrenia identified, 38 patients were assigned to the late\u2010onset group and 278 patients to the early\u2010onset group. Mean age at onset was 23.9 \u00b1 8.2 years for all men and 28.0 \u00b1 13.5 years for all women. The late\u2010onset group was characterized by more women, more paranoid type, more depressive symptoms, less introverted premorbid character, better premorbid adaptation and less neuroleptics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The characteristics of late\u2010onset schizophrenia in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan are in line those reported previously.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12032","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T02:57:55Z","timestamp":1385953075000},"page":"244-249","source":"Crossref","is-referenced-by-count":10,"title":["Clinical features of late\u2010onset schizophrenia in <scp>J<\/scp>apan: comparison with early\u2010onset cases"],"prefix":"10.1111","volume":"13","author":[{"given":"Manabu","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Psychiatry Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Kishi","sequence":"additional","affiliation":[{"name":"Center for Medical Informatics Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"259","article-title":"Die spate schizophrenen Krankheitsbilder","volume":"15","author":"Bleuler M","year":"1943","journal-title":"Fortschr Neurol Psychiatr"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/19.4.691"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.107.449.649"},{"key":"e_1_2_6_5_1","first-page":"515","article-title":"\u00dcber das kontaktmangelparanoid des h\u00f6heren alters und den symdrom charakter schizophrenen krankseins","volume":"44","author":"Janzarik W","year":"1973","journal-title":"Nervenarzt"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00350195","article-title":"Sp\u00e4tschizophrenie","volume":"221","author":"Huber G","year":"1975","journal-title":"Arch Psychiatr Nervenkr"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"A chart review study of late\u2010onset and early\u2010onset schizophrenia","volume":"146","author":"Pearlson GD","year":"1989","journal-title":"Am J Psychiatry"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01552.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02900216"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(1998110)13:11<775::AID-GPS868>3.0.CO;2-E"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.172"},{"key":"e_1_2_6_12_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_6_13_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_14_1","first-page":"169","volume-title":"Gender and Its Effects on Psychopathology","author":"Moldin SO","year":"2000"},{"key":"e_1_2_6_15_1","volume-title":"Die Sp\u00e4tschizophrenie","author":"Klages W","year":"1961"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.162.5.665"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(03)00015-X"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200311000-00003"},{"key":"e_1_2_6_19_1","first-page":"167","volume-title":"The Epidemiology of Schizophrenia","author":"Orr KGD","year":"2003"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/22.2.241"},{"key":"e_1_2_6_22_1","first-page":"1443","article-title":"Dose equivalence of psychotropic drugs. 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