{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:57:17Z","timestamp":1762999037997},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,16]],"date-time":"2014-02-16T00:00:00Z","timestamp":1392508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Restless legs syndrome (RLS<\/jats:styled-content>) is a common neurological disorder. Dementia with L<\/jats:styled-content>ewy bodies (DLB<\/jats:styled-content>) is the second most common form of neurodegenerative dementia after A<\/jats:styled-content>lzheimer's disease. Both RLS<\/jats:styled-content> and DLB<\/jats:styled-content> can be effectively treated by dopaminergic medications, suggesting the role of dopamine dysfunction in the pathogenesis of both diseases. Here, I<\/jats:styled-content> report on a J<\/jats:styled-content>apanese woman with probable DLB<\/jats:styled-content> and RLS<\/jats:styled-content> who was treated with gabapentin enacarbil, a non\u2010dopaminergic agent. Because a dopamine agonist, a first\u2010line therapy for moderate to severe RLS<\/jats:styled-content>, caused the occurrence of metamorphopsia, an alternative treatment of gabapentin enacarbil was used; this treatment improved the patient's RLS<\/jats:styled-content> without worsening her psychiatric symptoms. An alternative treatment is desirable for DLB<\/jats:styled-content> patients with RLS<\/jats:styled-content> because they often experience intolerable side\u2010effects with a dopamine agonist, especially visual hallucinations. Administering gabapentin enacarbil also improved the continuous leg pain that occurred in conjunction with the development of RLS<\/jats:styled-content>. Although the neurobiological mechanism in the development of pain remains unclear, a range of non\u2010dopaminergic structures likely mediated pain processing in DLB<\/jats:styled-content> in the present case based on neuropharmacological results. This is the first report reporting the effects of gabapentin enacarbil for RLS<\/jats:styled-content> and leg pain in a DLB<\/jats:styled-content> patient with psychiatric symptoms.<\/jats:p>","DOI":"10.1111\/psyg.12043","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T11:37:36Z","timestamp":1392637056000},"page":"132-134","source":"Crossref","is-referenced-by-count":15,"title":["Effects of gabapentin enacarbil on restless legs syndrome and leg pain in dementia with L<\/scp>ewy bodies"],"prefix":"10.1111","volume":"14","author":[{"given":"Hiroshige","family":"Fujishiro","sequence":"first","affiliation":[{"name":"Department of Psychiatry Nagoya University School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,16]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2006.01.001"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00010-8"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1986"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22322"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339363"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05115.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.3143\/geriatrics.49.622"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(02)00258-7"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.4065\/79.7.916"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22716"},{"key":"e_1_2_4_13_1","first-page":"653","article-title":"The progression of pathology in Parkinson's disease","volume":"16","author":"Halliday GM","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.09.036"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.018"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh441"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000210948.11805.69"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.01.021"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.12.004"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.11.007"}],"container-title":["Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpsyg.12043","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T21:14:49Z","timestamp":1696194889000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyg.12043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,16]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/psyg.12043"],"URL":"https:\/\/doi.org\/10.1111\/psyg.12043","archive":["Portico"],"relation":{},"ISSN":["1346-3500","1479-8301"],"issn-type":[{"value":"1346-3500","type":"print"},{"value":"1479-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,16]]}}}