{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T03:17:21Z","timestamp":1785640641568,"version":"3.56.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have reported that elevated total homocysteine levels are associated with cognitive dysfunction. However, few studies have examined the radiological markers of associated neuropathology in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>). We hypothesized that elevated levels of homocysteine are associated with cerebral grey matter volume loss. We compared the grey matter in a high homocysteine group and a normal homocysteine group using an optimized voxel\u2010based morphometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 79 patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> who were divided into two groups: a high homocysteine group and a normal homocysteine group. The participants underwent brain magnetic resonance imaging using a standardized protocol and neurocognitive evaluation. Homocysteine tests and other routine laboratory examinations for dementia assessment were carried out in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in grey matter volume between the patients with high homocysteine levels and those with normal homocysteine levels. A multiple regression analysis also revealed that the levels of homocysteine were not associated with the grey matter volume in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Homocysteine levels were not correlated significantly with <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ini\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ental <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tate <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>xamination, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lobal <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>eterioration <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale, or <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linical <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ementia <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results showed that elevated homocysteine levels are not associated with reduced cerebral grey matter volume in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Larger samples will be needed to assess potential correlations between homocysteine and neuroanatomical pathology in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12082","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T09:44:19Z","timestamp":1420451059000},"page":"116-122","source":"Crossref","is-referenced-by-count":6,"title":["Correlations between homocysteine and grey matter volume in patients with <scp>A<\/scp>lzheimer's disease"],"prefix":"10.1111","volume":"15","author":[{"given":"Seong Hyeok","family":"Park","sequence":"first","affiliation":[{"name":"Department of Psychiatry Ilsan Paik Hospital Inje University College of Medicine  Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ilsan Paik Hospital Inje University College of Medicine  Goyang South 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