{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:21:19Z","timestamp":1791249679133,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of the present study was to investigate the existence of microstructure abnormalities in the white matter circuit in stroke patients and its relationship to depressive episodes. To target the prevention of depression, we also investigated the relationship between lymphocyte subsets and cerebral abnormalities in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants included 18 patients with acute ischemic stroke and 22 healthy control subjects. Diffusion tensor imaging was performed. Whole\u2010brain voxel\u2010based analysis was used to compare fractional anisotropy (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>) between groups. Blood samples were obtained, and the lymphocyte subsets were evaluated using flow cytometry. Follow\u2010up examinations were conducted on 12 patients at 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> was decreased in the bilateral anterior limb of the internal capsule in stroke patients. At the 6\u2010month follow\u2010up examination, there was a significant increase in <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>, which was associated with a lower depression scale score. Patients showed a decreased percentage of circulated regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> lymphocytes, and the degree of reduction was related to the decrease in the <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> value in the internal capsule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> reductions in the anterior limb of the internal capsule cause abnormality in the frontal\u2010subcortical circuits and confer a biological vulnerability, which in combination with environmental stressors results in the onset of depression. Our findings also demonstrated the possibility of preventing post\u2010stroke depression by targeting the role of regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> lymphocytes in brain tissue repair and regeneration after stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12084","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T06:56:31Z","timestamp":1418367391000},"page":"213-221","source":"Crossref","is-referenced-by-count":14,"title":["Microstructural abnormality in white matter, regulatory <scp>T<\/scp> lymphocytes, and depressive symptoms after stroke"],"prefix":"10.1111","volume":"14","author":[{"given":"Fumihiko","family":"Yasuno","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Nara Medical University  Kashihara"},{"name":"Department of Investigative Radiology National Cerebral and Cardiovascular Center  Kobe 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