{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:35:03Z","timestamp":1767706503310,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology in Japan","doi-asserted-by":"crossref","award":["20536924"],"award-info":[{"award-number":["20536924"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is clinically characterized by gradual onset over years with worsening of cognition. The initial and most prominent cognitive deficit is commonly memory dysfunction. However, a subset of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> cases has less hippocampal atrophy than would be expected relative to the predominance of cortical atrophy. These hippocampal\u2010sparing cases have distinctive clinical features, including the presence of focal cortical clinical syndromes. Given that previous studies have indicated that severe hippocampal atrophy corresponds to prominent loss of episodic memory, it is likely that memory impairment is initially absent in hippocampal\u2010sparing <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> cases. Here, we report on a patient with an 8\u2010year history of delusional jealousy with insidious onset who was clinically diagnosed as possible <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and pathologically confirmed to have <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> with relatively preserved neurons in the hippocampus. This patient had delusional jealousy with a long pre\u2010dementia stage, which initially was characterized by lack of memory impairment. Head magnetic resonance imaging findings showed preserved hippocampal volume with bilateral enlarged ventricles and mild\u2010to\u2010moderate cortical atrophy. Head single\u2010photon emission computed tomography revealed severely decreased regional cerebral blood flow in the right temporal lobe. The resolution of the delusion was attributed to pharmacotherapy by an acetylcholinesterase inhibitor, suggesting that the occurrence of delusional jealousy was due to the disease process of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Although the neural basis of delusional jealousy remains unclear, this hippocampal\u2010sparing <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> case may be classified as an atypical presentation of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/psyg.12105","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T10:23:11Z","timestamp":1425378191000},"page":"198-203","source":"Crossref","is-referenced-by-count":6,"title":["Autopsy\u2010confirmed hippocampal\u2010sparing <scp>A<\/scp>lzheimer's disease with delusional jealousy as initial manifestation"],"prefix":"10.1111","volume":"15","author":[{"given":"Hiroshige","family":"Fujishiro","sequence":"first","affiliation":[{"name":"Department of Sleep Medicine Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Iritani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Okehazama Hospital Fujita Mental Care Center  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Okehazama Hospital Fujita Mental Care Center  Toyoake 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute for Medical Science of Ageing Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Okehazama Hospital Fujita Mental Care Center  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"146","article-title":"\u00dcber eine eigenartige Erkrankung der Hirnrinde","volume":"64","author":"Alzheimer A","year":"1907","journal-title":"Allg Z 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