{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:11:26Z","timestamp":1773922286555,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology, Japan","doi-asserted-by":"crossref","award":["26461750"],"award-info":[{"award-number":["26461750"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Graduate School of Medical Sciences, Kumamoto University, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The features of behavioural and psychological symptoms of dementia (<jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content>) are influenced by dementia stage. In early\u2010onset <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease (<jats:styled-content style=\"fixed-case\">EOAD<\/jats:styled-content>), the association between <jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content> and dementia stage remains unclear because of the difficulty of recruiting subjects with a wide range of disease severity. We used a combination of community\u2010based and hospital\u2010based approaches to investigate the relationship between dementia severity and <jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">EOAD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010three consecutive <jats:styled-content style=\"fixed-case\">EOAD<\/jats:styled-content> outpatients and 29 <jats:styled-content style=\"fixed-case\">EOAD<\/jats:styled-content> patients from a community\u2010based survey were divided into three dementia severity groups according to the Clinical Dementia Rating scale (<jats:styled-content style=\"fixed-case\">CDR<\/jats:styled-content>): mild (<jats:styled-content style=\"fixed-case\">CDR<\/jats:styled-content> 0.5\u20131, <jats:italic>n<\/jats:italic> = 55), moderate (<jats:styled-content style=\"fixed-case\">CDR<\/jats:styled-content> 2, <jats:italic>n<\/jats:italic> = 17), and severe (<jats:styled-content style=\"fixed-case\">CDR<\/jats:styled-content> 3, <jats:italic>n<\/jats:italic> = 20). <jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content> were rated using the Neuropsychiatric Inventory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Scores of the Neuropsychiatric Inventory subscales agitation, euphoria, apathy, disinhibition, irritability, and aberrant motor behaviour increased significantly with increased dementia severity. Hallucinations were greater in the moderate group than in the mild group. For delusions, depression, and anxiety, no significant differences were observed among the three severity groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pattern of apathy, agitation, disinhibition, irritability, and aberrant motor behaviour worsening with severity progression in <jats:styled-content style=\"fixed-case\">EOAD<\/jats:styled-content> is similar to the pattern in late\u2010onset <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease. In contrast, hallucinations, depression, and anxiety showed different patterns in <jats:styled-content style=\"fixed-case\">EOAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12108","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T10:23:47Z","timestamp":1425378227000},"page":"242-247","source":"Crossref","is-referenced-by-count":65,"title":["Relationship between dementia severity and behavioural and psychological symptoms in early\u2010onset <scp>A<\/scp>lzheimer's disease"],"prefix":"10.1111","volume":"15","author":[{"given":"Hibiki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Graduate School of Medical Science Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Faculty of Life Sciences Kumamoto University  Kumamoto 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