{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:45:08Z","timestamp":1790279108739,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the present study was to investigate whether the effects of vitamin <jats:styled-content style=\"fixed-case\">B<jats:sub>12<\/jats:sub><\/jats:styled-content> and homocysteine on brain volume are influenced by apolipoprotein <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>APOE<\/jats:italic><\/jats:styled-content>) genotype. We examined the effects in each subgroup (<jats:italic><jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content><\/jats:italic> \u03b54 carriers and non\u2010carriers) of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) patients and healthy normal controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty participants with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and 20 healthy normal controls were recruited from memory impairment clinics at <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>usan <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital in <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orea. All participants were <jats:styled-content style=\"fixed-case\"><jats:italic>APOE<\/jats:italic><\/jats:styled-content> genotyped and underwent magnetic resonance imaging, including 3\u2010D volumetric images for grey matter (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) volume. A multiple regression model integrated into statistical parametric mapping was used to see if there was any correlation between vitamin <jats:styled-content style=\"fixed-case\">B<jats:sub>12<\/jats:sub><\/jats:styled-content> or homocysteine and <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume in each subgroup (<jats:italic><jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content><\/jats:italic> \u03b54 carriers and non\u2010carriers) of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients and healthy normal controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant positive correlation between serum concentrations of vitamin <jats:styled-content style=\"fixed-case\">B<jats:sub>12<\/jats:sub><\/jats:styled-content> and regional <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume in <jats:italic><jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content><\/jats:italic> \u03b54 carriers with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> but not in non\u2010carriers. We also found that there was a significant negative correlation between serum concentrations of homocysteine and regional <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume in <jats:italic><jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content><\/jats:italic> \u03b54 non\u2010carriers with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> but not in carriers (<jats:italic>P<\/jats:italic> &lt; 0.001, uncorrected for multiple comparisons; extent threshold = 100 voxel).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present findings suggest that the effects of vitamin <jats:styled-content style=\"fixed-case\">B<jats:sub>12<\/jats:sub><\/jats:styled-content> and homocysteine on <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume might be influenced by <jats:styled-content style=\"fixed-case\"><jats:italic>APOE<\/jats:italic><\/jats:styled-content> genotype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12109","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T08:39:42Z","timestamp":1430123982000},"page":"3-11","source":"Crossref","is-referenced-by-count":14,"title":["Apolipoprotein <scp>E<\/scp> genotype modulates effects of vitamin <scp>B<sub>12<\/sub><\/scp> and homocysteine on grey matter volume in <scp>A<\/scp>lzheimer's disease"],"prefix":"10.1111","volume":"16","author":[{"given":"Young\u2010Min","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Psychiatry Pusan National University School of Medicine  Busan Korea"},{"name":"Biomedical Research Institute Pusan National University Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Kyung","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pusan National University School of Medicine  Busan 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