{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:02:55Z","timestamp":1761418975895},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Depression is a frequent comorbid condition in patients with Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>). In the present study, we reported the effect of additional donepezil treatment for patients with geriatric depression who exhibited cognitive deficit and were diagnosed with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> during treatment for depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present retrospective study investigated 14 <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> outpatients who were diagnosed with geriatric depression at first and received antidepressant treatment. When apparent cognitive decline was observed, all of them were diagnosed with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and received donepezil (5\u2009mg\/day) for at least 1 year. All patients underwent periodic examination of cognitive function (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ini\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ental <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tate Examination, Rorschach Cognitive Index) and clinical evaluation (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linical <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ementia Rating). The 14 patients were classified into three groups according to their treatment course: (i) \u2018A\u2019 group, patients who showed cognitive impairment during a long course of treatment for depression; (ii) \u2018B\u2019 group, patients who showed cognitive impairment at an early stage of treatment for depression and started to take additional donepezil at least 20 months after the first examination; and (iii) \u2018C\u2019 group, patients who showed cognitive impairment at an early stage of treatment for depression and began taking additional donepezil within 10 months of the first examination. The clinical feature and treatment effects were examined for each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1 and 2 years after the start of treatment, the proportion of patients who had improved or maintained their <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linical <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ementia Rating score was higher in \u2018A\u2019 and \u2018C\u2019 groups than in \u2018B\u2019 group. In \u2018B\u2019 group, additional donepezil treatment commenced later than in the other groups. Therefore, donepezil had an insufficient curative effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study suggested that early induction of donepezil treatment was necessary when apparent cognitive decline was identified during the treatment of geriatric depression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12121","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T08:43:31Z","timestamp":1430124211000},"page":"54-61","source":"Crossref","is-referenced-by-count":2,"title":["Additional donepezil treatment for patients with geriatric depression who exhibit cognitive deficit during treatment for depression"],"prefix":"10.1111","volume":"16","author":[{"given":"Jun","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurology Hamamatsu University School of Medicine  Hamamatsu Shizuoka Japan"},{"name":"Okamoto Clinic  Kikugawa Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Okamoto Clinic  Kikugawa Shizuoka Japan"},{"name":"Department of Psychiatry Kanarekai Koujin Hospital  Nagoya Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Nojima","sequence":"additional","affiliation":[{"name":"Okamoto Clinic  Kikugawa Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Numazu Senbon Hospital  Numazu City Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Okamoto Clinic  Kikugawa Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.8.1290"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181aa52d3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_5_7_1","first-page":"63","article-title":"A comparative study of cognitive function in patients with senile dementia of Alzheimer\u2010type and vascular dementia","volume":"5","author":"Hoshino R","year":"1994","journal-title":"Jpn J Geriatric Psychiatry"},{"key":"e_1_2_5_8_1","first-page":"409","article-title":"A study on the new Rorschach scale for evaluating cognitive function in aged person","volume":"7","author":"Hoshino R","year":"1996","journal-title":"Jpn J Geriatric Psychiatry"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2010.00319.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610209990184"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2009.00291.x"}],"container-title":["Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpsyg.12121","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:40:37Z","timestamp":1695980437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyg.12121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,27]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/psyg.12121"],"URL":"https:\/\/doi.org\/10.1111\/psyg.12121","archive":["Portico"],"relation":{},"ISSN":["1346-3500","1479-8301"],"issn-type":[{"value":"1346-3500","type":"print"},{"value":"1479-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,27]]}}}