{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:03:44Z","timestamp":1773867824657,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["20536924"],"award-info":[{"award-number":["20536924"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Discrepancies between clinical and pathological diagnoses of dementia with Lewy bodies (<jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>) may occur because the full disease progression remains unclear, especially during the early stage. Herein, we report the case of a 78\u2010year\u2010old Japanese man with hypochondriasis who had autopsy\u2010confirmed limbic\u2010type <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> pathology. He exhibited no core clinical features of <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>. We attempted to identify the clinicopathological correlations in the early stages of <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>. At the age of 77, he became hypochondriacal and exhibited progressive cognitive decline after the death of his wife. He was concerned about his poor physical condition, but hospital examinations did not identify any overtly abnormal findings. At 78 years of age, he consulted a neurologist with complaints of <jats:italic>facial numbness and irritability<\/jats:italic>. Neurological examination revealed no overt abnormality, and he scored 21 points on the Mini\u2010Mental State Examination. Magnetic resonance imaging of the brain showed mild bilateral ventricular enlargement. The patient was clinically diagnosed as having possible Alzheimer's disease. Approximately 1 month after his consult, he died of acute pneumonia in a psychiatric hospital to which he had been admitted for severe aggressive behaviour. He exhibited no core clinical features pointing towards a clinical diagnosis of <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>. Neuropathological investigation revealed limbic\u2010type Lewy body disease with concurrent minimum Alzheimer\u2010type pathology, which corresponds to high\u2010likelihood <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> pathology based on the Third Consortium <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> pathological criteria. The patient had minimum nigral degeneration, which is consistent with the absence of parkinsonism. This autopsied case suggests that some <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> patients exhibit hypochondriasis in the early stage of the disease, even if they lack the core clinical features of <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/psyg.12128","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T08:44:39Z","timestamp":1430124279000},"page":"139-144","source":"Crossref","is-referenced-by-count":7,"title":["Hypochondriasis as an early manifestation of dementia with <scp>L<\/scp>ewy bodies: an autopsied case report"],"prefix":"10.1111","volume":"16","author":[{"given":"Hiroshige","family":"Fujishiro","sequence":"first","affiliation":[{"name":"Department of Sleep Medicine Graduate School of Medicine Nagoya University  Nagoya 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