{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:19:30Z","timestamp":1768346370080,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As with other types of dementia, the behavioral and psychological symptoms of dementia (<jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content>) can make caregiving difficult for patients with dementia with <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewy bodies (<jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>). We hypothesized that administration of donepezil at an increased dose of 10\u2009mg\/day might dose\u2010dependently improve <jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> patients with relapse, after their symptoms had been controlled initially by donepezil therapy at the standard dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study was as an open\u2010label trial. We enrolled 24 patients with <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> (diagnosed according to the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>onsortium on <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ementia with <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewy <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>odies <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>uideline\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>evised) who experienced a relapse of <jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content> despite treatment with donepezil at the standard dose (5\u2009mg\/day). The donepezil dose for these patients was increased to 10\u2009mg\/day, and we evaluated the efficacy and safety of this dose escalation strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>europsychiatric <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nventory (<jats:styled-content style=\"fixed-case\">NPI<\/jats:styled-content>) scores for <jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content> showed statistically significant improvements as a result of the increased dosage, except those for anxiety and euphoria, disinhibition, irritability\/lability. High\u2010dose donepezil therapy caused gastrointestinal symptoms in 4 patients, but there were no life\u2010threatening adverse events, such as arrhythmias, or no exacerbation of parkinsonian symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that donepezil dose\u2010dependently improved relapsing <jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content> in these patients. Therefore, increasing the dosage of donepezil is a safe and effective treatment for patients with <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> who experience a relapse of <jats:styled-content style=\"fixed-case\">BPSD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12140","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T08:57:35Z","timestamp":1437037055000},"page":"202-208","source":"Crossref","is-referenced-by-count":13,"title":["Increased dosage of donepezil for the management of behavioural and psychological symptoms of dementia in dementia with <scp>L<\/scp>ewy bodies"],"prefix":"10.1111","volume":"16","author":[{"given":"Yuta","family":"Manabe","sequence":"first","affiliation":[{"name":"Dementia Diagnosis Center, Department of Internal Medicine Yokohama Shintoshi Neurosurgical Hospital  Yokohama Japan"},{"name":"Medical Care Court Clinic  Yokohama Japan"},{"name":"Department of Emergency and General Internal Medicine Fujita Health University, School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruo","family":"Ino","sequence":"additional","affiliation":[{"name":"Department of Emergency and General Internal Medicine Fujita Health University, School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuo","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Emergency and General Internal Medicine Fujita Health University, School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kosaka","sequence":"additional","affiliation":[{"name":"Medical Care Court Clinic  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.7.4.476"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03399-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351672"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23557"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2006.01485.x"},{"key":"e_1_2_5_8_1","first-page":"1165","article-title":"Efficacy of high\u2010dose donepezil in the treatment of neuropsychiatric symptoms in cases of dementia with Lewy bodies. 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