{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:51:39Z","timestamp":1790016699476,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      lzheimer's disease (\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ) and major depressive disorder are the two most common psychogeriatric disorders. Late\u2010onset depression (\n                      <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                      ) is the most common cause of emotional suffering in the elderly and is associated with a poor quality of life in caregivers. Although the burden on caregivers of individuals suffering from\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      has been well studied, there is a paucity of comparative studies on caregiver burden between\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                      . The objectives of this study were to compare the caregiver burden in\n                      <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      and to identify factors associated with caregiver burden in\n                      <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study included two groups of 25 patients and their caregivers. Group 1 consisted of LOD patients diagnosed with major depressive disorder according to the\n                      <jats:italic>Diagnostic and Statistical Manual of Mental Disorders<\/jats:italic>\n                      , 4th edition, text revision, with onset after age 60, and their caregivers. Group 2 consisted of\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      patients and their caregivers. Caregiver burden was assessed by the\n                      <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>\n                      arit Caregiver Burden Interview. Sociodemographic and clinical correlates of caregiver burden in\n                      <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no significant difference in caregiver burden between\n                      <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.27). In\n                      <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                      , the factors positively associated with caregiver burden included the patient's education and the caregiver being a woman, married, unmarried, and a student. Factors negatively associated with caregiver burden included being the son of the patient and high income status. Multivariate stepwise regression analysis showed that caregiver burden in\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      is predicted by the Behavioural Pathology in Alzheimer's Disease Scale score, income, presence of diabetes, and in\u2010laws as caregivers (adjusted\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\n                      <\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.847,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). In\n                      <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                      , caregiver burden is predicted by income, the patient's education, and whether the caregiver is a student or spouse (adjusted\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\n                      <\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.388,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study highlights the finding that caregiver burden in\n                      <jats:styled-content style=\"fixed-case\">LOD<\/jats:styled-content>\n                      is comparable to that in\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      and requires interventions to reduce the caregiver strain.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/psyg.12141","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T07:26:21Z","timestamp":1437031581000},"page":"209-215","source":"Crossref","is-referenced-by-count":13,"title":["A comparative study of caregiver burden in late\u2010onset depression and\n                    <scp>A<\/scp>\n                    lzheimer's disease"],"prefix":"10.1111","volume":"16","author":[{"given":"Firoz","family":"Kazhungil","sequence":"first","affiliation":[{"name":"Department of Psychiatry Government Medical College  Manjeri Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajmohan","family":"Velayudhan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry MES Medical College  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