{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:46:51Z","timestamp":1787960811855,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T00:00:00Z","timestamp":1444089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>Aims<\/jats:title>Previous studies have suggested that insulin\u2010like growth factor\u2010I (IGF<\/jats:styled-content>\u2010I) deficiency may lead to cognitive deficits in neurodegenerative diseases such as Alzheimer's disease. The present study aimed to investigate the possible relationship between cognitive function and concentration of IGF<\/jats:styled-content>\u2010I or amyloid beta protein (A\u03b2<\/jats:styled-content>) in serum in Alzheimer's patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 81 Japanese patients were enrolled in this study. Concentrations of IGF<\/jats:styled-content>\u2010I, A\u03b242<\/jats:styled-content>, and A\u03b240<\/jats:styled-content> in serum were measured. Two neuropsychological tests, Mini\u2010Mental State Examination and Hasegawa's Dementia Scale\u2010Revised (HDS<\/jats:styled-content>\u2010R), were also performed. Linear correlations among the age, serum IGF<\/jats:styled-content>\u2010I, serum A\u03b242<\/jats:styled-content> or A\u03b240<\/jats:styled-content>, A\u03b242<\/jats:styled-content>\/A\u03b240<\/jats:styled-content> ratio, Mini\u2010Mental State Examination or HDS<\/jats:styled-content>\u2010R total score, and the scores for six HDS<\/jats:styled-content>\u2010R subscales were analyzed by regression analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>IGF<\/jats:styled-content>\u2010I showed a significant negative correlation with age (\u03b2 = \u22120.357, P<\/jats:italic> = 0.002) and a positive correlation with A\u03b242<\/jats:styled-content>\/A\u03b240<\/jats:styled-content> ratio (\u03b2 = 0.318, P<\/jats:italic> = 0.007). Serum IGF<\/jats:styled-content>\u2010I and both the Mini\u2010Mental State Examination and the HDS<\/jats:styled-content>\u2010R total score also correlated (\u03b2 = 0.505, \u03b2 = 0.524, P<\/jats:italic> < 0.01). Among the HDS<\/jats:styled-content>\u2010R subscales, \u2018Recall\u2019 (\u03c1 = 0.379, P<\/jats:italic> < 0.01), \u2018Verbal fluency\u2019 (\u03c1 = 0.360, P<\/jats:italic> < 0.01), and \u2018Attention and calculation\u2019 (\u03c1 = 0.389, P<\/jats:italic> < 0.01) showed significant positive correlations with serum IGF<\/jats:styled-content>\u2010I.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The results, specifically that lower serum IGF<\/jats:styled-content>\u2010I was associated with cognitive impairment, suggest that metabolism of IGF<\/jats:styled-content>\u2010I may be involved in the pathogenesis of cognitive deficits in Alzheimer's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12149","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T05:28:43Z","timestamp":1444109323000},"page":"247-254","source":"Crossref","is-referenced-by-count":23,"title":["Serum insulin\u2010like growth factor\u2010I and amyloid beta protein in Alzheimer's disease: relationship with cognitive function"],"prefix":"10.1111","volume":"16","author":[{"given":"Ayako","family":"Kimoto","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Science Graduate School of Medicine Juntendo University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kasanuki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Science Graduate School of Medicine Juntendo University Tokyo Japan"},{"name":"Juntendo Tokyo Koto Geriatric Medical Center Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Science Graduate School of Medicine Juntendo University Tokyo Japan"},{"name":"Juntendo Tokyo Koto Geriatric Medical Center Juntendo University School of Medicine Tokyo 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