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They undergo computed tomography (CT<\/jats:styled-content>) neuroradiological examination at least once or twice a year. For this study, the accumulative data, including clinical and neuroradiological, were analyzed.<\/jats:p><\/jats:sec>Methods<\/jats:title>Differential diagnoses of A<\/jats:styled-content>lzheimer's disease were performed in accordance with the N<\/jats:styled-content>ational Institute of N<\/jats:styled-content>eurological and C<\/jats:styled-content>ommunicative D<\/jats:styled-content>isorders and S<\/jats:styled-content>troke and the A<\/jats:styled-content>lzheimer's D<\/jats:styled-content>isease and R<\/jats:styled-content>elated D<\/jats:styled-content>isorders A<\/jats:styled-content>ssociation criteria. The 56 patients (15 men, 41 women) included in this study underwent in\u2010hospital observation on average for 4.4 years (range: 1\u201310 years). The patients were classified into four groups according to the age of disease onset. The CT<\/jats:styled-content> findings were summarized for each group and then compared among the groups to determine if there were any differences related to age of onset and, if so, to identify and analyze them.<\/jats:p><\/jats:sec>Results<\/jats:title>(1) The duration of deceased cases' total clinical course (in years) compared among the four groups. In general, the degree of dementia was more severe among those with earlier disease onset. (2) In cases admitted within 2 years from onset (n<\/jats:italic>\u2009=14), the suspected initiating focus of cortical atrophy occurred in the frontal lobe (n<\/jats:italic>\u2009=\u20096), the temporal lobe (n<\/jats:italic>\u2009=\u20096), or the fronto\u2010temporal lobes (n<\/jats:italic>\u2009=\u20092). (3) Although CT<\/jats:styled-content> findings generally showed that the more severe cases had earlier onset, serial CT<\/jats:styled-content> examinations in each case showed widely different pathologies in degree, nature and manner of progression, regardless of group classification. (4) The earliest sites of brain atrophy, sites of its severest involvement within the brain, and neuroradiological development of the cerebral cortex pathology in combination with hemispheric white matter, lateral ventricles, and third ventricles varied among the four groups and between case within each group. A<\/jats:styled-content>lzheimer's disease could not be subclassified simply by the age of clinical onset.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Cases of so\u2010called A<\/jats:styled-content>lzheimer's disease, as observed through continued clinical follow\u2010up and serial CT<\/jats:styled-content> examinations, appear so diverse in symptomatology and radiological pathomorphology that it is difficult to consider them a single nosological entity. The pathology of Alzheimer's disease has to be reconsidered in accordance with the variety observed in the sequential development of neuroradiological findings. The pathology must be reconstructed in terms of topographical dimensions and chronological developments. The diagnosis of Alzheimer's disease appears to be not so simple based on any conventional diagnostic operational standards.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12162","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T18:26:50Z","timestamp":1450722410000},"page":"255-271","source":"Crossref","is-referenced-by-count":3,"title":["Alzheimer's disease or A<\/scp>lzheimer's syndrome?: a longitudinal computed tomography neuroradiological follow\u2010up study of 56 cases diagnosed clinically as A<\/scp>lzheimer's disease"],"prefix":"10.1111","volume":"15","author":[{"given":"Kohshiro","family":"Fujisawa","sequence":"first","affiliation":[{"name":"Department of Geriatric Psychiatry Yokohama \u2013 Houyuu Hospital Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadaharu","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry Yokohama \u2013 Houyuu Hospital Yokohama 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