{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T13:35:09Z","timestamp":1778420109519,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study investigated whether the characteristic changes in hippocampal atrophy seen in coronal scans are useful for differentiating Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>), amnestic mild cognitive impairment (a<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>), and major depressive disorder (<jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects included 58 patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, 33 with a<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>, 20 with <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>, and 22 normal controls, all aged 60 years or older. For each subject, eight coronal short <jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content> inversion recovery images perpendicular to the hippocampal longitudinal axis were obtained. Images were manually measured using the conventional region of interest method of quantitative analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall trend in the corrected volumes of the hippocampus was <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> &lt; a<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> &lt; <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> &lt; normal controls. We found atrophy in all slices in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, atrophy centred on the hippocampal head in aMCI, and atrophy in the slice of the hippocampal body 12 mm from the amygdala in <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study suggested that our method of comparing hippocampal atrophy by region may be useful in distinguishing <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, a<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>, and normal controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12176","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T08:03:24Z","timestamp":1452585804000},"page":"355-361","source":"Crossref","is-referenced-by-count":23,"title":["Patterns of hippocampal 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