{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:21:03Z","timestamp":1761060063055},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Lewy body disease (LBD<\/jats:styled-content>), including Parkinson's disease (PD<\/jats:styled-content>) and dementia with Lewy bodies (DLB<\/jats:styled-content>), is defined pathologically as degeneration in the central and peripheral nervous system associated with Lewy bodies. Somatic symptom disorder often predates the clinical diagnosis of PD<\/jats:styled-content> and DLB<\/jats:styled-content>. It is crucial to make an initial diagnosis of LBD<\/jats:styled-content> in patients with psychiatric symptoms because administering psychotropic drugs often causes or exacerbates extrapyramidal signs. Given the close association between rapid eye movement (REM<\/jats:styled-content>) sleep behaviour disorder and LBD<\/jats:styled-content>, REM<\/jats:styled-content> sleep without atonia on polysomnography may help to diagnose LBD<\/jats:styled-content> in middle\u2010aged and older patients with somatic symptom disorder.<\/jats:p><\/jats:sec>Methods<\/jats:title>We reviewed the clinical profiles of five patients with an initial diagnosis of somatic symptom disorder who exhibited REM<\/jats:styled-content> sleep without atonia on polysomnography. There were three men and two women, with a mean age of 68.4 years (range: 55.0\u201378.0 years). The mean Mini\u2010Mental State Examination score was 26 (range: 22\u201330).<\/jats:p><\/jats:sec>Results<\/jats:title>Only two patients had a clinical history of dream\u2010enacting behaviour and fulfilled the clinical criteria for REM<\/jats:styled-content> sleep behaviour disorder, but clinical conditions in the other three patients corresponded to subclinical REM<\/jats:styled-content> sleep behaviour disorder. Final clinical diagnoses were made as probable DLB<\/jats:styled-content> in three patients; two patients did not meet the clinical criteria for PD<\/jats:styled-content> or DLB<\/jats:styled-content>. Neurological examinations revealed mild extrapyramidal signs in these two patients, and their scores on the motor component of the U<\/jats:styled-content>nified P<\/jats:styled-content>arkinson's D<\/jats:styled-content>isease R<\/jats:styled-content>ating S<\/jats:styled-content>cale were 8 and 5 points, and their Mini\u2010Mental State Examination scores were 30 points. Neither patient exhibited dream\u2010enacting behaviour, but both had constipation. Cardiac 123<\/jats:sup>I\u2010metaiodobenzylguanidine scintigraphy revealed mild increased washout rates.<\/jats:p><\/jats:sec>Discussion<\/jats:title>\nREM<\/jats:styled-content> sleep without atonia may provide an opportunity to identify LBD<\/jats:styled-content> in patients with somatic symptom disorder, even before they fulfil the clinical criteria for PD<\/jats:styled-content> or DLB<\/jats:styled-content>. Continued follow\u2010up will be needed to determine whether these psychiatric patients are in the prodromal stage of PD<\/jats:styled-content> or DLB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12181","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T08:12:34Z","timestamp":1452586354000},"page":"61-69","source":"Crossref","is-referenced-by-count":8,"title":["Rapid eye movement sleep without atonia may help diagnose L<\/scp>ewy body disease in middle\u2010aged and older patients with somatic symptom disorder"],"prefix":"10.1111","volume":"17","author":[{"given":"Takayuki","family":"Munechika","sequence":"first","affiliation":[{"name":"Department of Psychiatry Nagoya University School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshige","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University School of Medicine Nagoya Japan"},{"name":"Department of Sleep Medicine Nagoya University School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine Nagoya University School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youta","family":"Torii","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Iritani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200108000-00001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12179"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12128"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181df09dd"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2009.05115.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.10.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822c9148"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(13)70056\u20105"},{"key":"e_1_2_7_10_1","first-page":"42","volume-title":"The AASM Manual for the Scoring of Sleep and Associated events: Rules, Technology, and Technical Specifications","author":"Iber C","year":"2007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.12.1627"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1886"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.09.028"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.02.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23257"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000247"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.07.022"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.l05877gry"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.11.019"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.2.331"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_24_1","unstructured":"American Academy of Sleep Medicine.International Classification of Sleep Disorders: Diagnostic and Coding Manual 2nd edn.Westchester IL 2005;148\u2013152."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00818.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.03.027"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12466"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339363"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12005"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.05.019"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21560"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21076"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.078816"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.08.017"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0398-7"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.5.507"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e31827c6bdd"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25523"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.10.011"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-012-0253-z"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10577"},{"issue":"7","key":"e_1_2_7_42_1","first-page":"38","article-title":"Weight loss in Parkinson's disease","volume":"253","author":"Kashihara K","year":"2006","journal-title":"J Neurol"},{"key":"e_1_2_7_43_1","first-page":"653","article-title":"The progression of pathology in Parkinson's disease","volume":"16","author":"Halliday GM","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.09.036"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010011\u20101963\u20101"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.01.009"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20369"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3102"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001215"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0155-x"}],"container-title":["Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpsyg.12181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpsyg.12181","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:56:12Z","timestamp":1695506172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyg.12181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,12]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/psyg.12181"],"URL":"https:\/\/doi.org\/10.1111\/psyg.12181","archive":["Portico"],"relation":{},"ISSN":["1346-3500","1479-8301"],"issn-type":[{"value":"1346-3500","type":"print"},{"value":"1479-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,12]]}}}