{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:06:51Z","timestamp":1791860811909,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T00:00:00Z","timestamp":1485561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neuroinflammation has been recognized as a feature of Alzheimer's disease (AD), and mild cognitive impairment (MCI) is believed to share several pathological features with AD. The aim of the present study was to compare serum cytokine levels between patients with AD, subjects with MCI, and healthy controls, and to assess the correlation between cytokine levels and cognitive performance in these subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants included 35 patients with AD, 29 subjects with MCI, and 28 healthy controls from the Department of Psychiatry of IIlsan Paik Hospital in South Korea. Demographic and neuropsychological information were obtained, and peripheral cytokine levels, specifically tumour necrosis factor (TNF)\u2010\u03b1 and interleukin (IL)\u20106 levels, were measured for all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjustment for age, a significant difference in IL\u20106 levels (<jats:italic>P<\/jats:italic> = 0.045), but not in TNF\u2010\u03b1 (<jats:italic>P<\/jats:italic> = 0.082) levels, was observed among the three groups. IL\u20106 levels were higher in patients with AD than in subjects with MCI and healthy controls. TNF\u2010\u03b1 and IL\u20106 levels negatively and positively correlated with Mini\u2010Mental State Examination and Global Deterioration Scale scores, respectively. TNF\u2010\u03b1 and IL\u20106 levels were also positively correlated with each other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study suggests that serum IL\u20106 levels of patients with AD might be higher than those of subjects with MCI and healthy controls. Serum TNF\u2010\u03b1 and IL\u20106 levels might be negatively correlated with cognitive function, and we suspect that serum IL\u20106 levels could be biomarkers for AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12218","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T05:37:04Z","timestamp":1485581824000},"page":"224-230","source":"Crossref","is-referenced-by-count":86,"title":["Serum tumour necrosis factor\u2010\u03b1 and interleukin\u20106 levels in Alzheimer's disease and mild cognitive impairment"],"prefix":"10.1111","volume":"17","author":[{"given":"Yo Sup","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Ilsan Paik Hospital Inje University College of Medicine  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Joon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Ilsan Paik Hospital Inje University College of Medicine  Goyang 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