{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T18:08:55Z","timestamp":1771524535112,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T00:00:00Z","timestamp":1485561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In recent years, as the prevalence of Alzheimer\u2027s disease (AD) has increased rapidly, demand has increased for early detection and treatment. Therefore, discovery and treatment intervention at the mild cognitive impairment stage are important. Dysfunction of the working memory is known to be conspicuously present in AD patients or mild cognitive impairment subjects from an early stage. Near\u2010infrared spectroscopy (NIRS) is a method to measure hemoglobin concentration changes during an activation task. In the present study, we evaluated the cognitive function of elderly subjects, including those with AD, by means of NIRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were divided into three groups\u2014the AD group, the intermediate group, and the healthy group (HG)\u2014based on assement of dementia using the Hasegawa\u2027s Dementia Scale\u2010Revised, Mini\u2010Mental State Examination, and Clinical Dementia Rating. The intermediate group was divided into two groups\u2014the high score group (HSMG) and the low score group (LSMG)\u2014based on Hasegawa\u2027s Dementia Scale\u2010Revised and Mini\u2010Mental State Examination scores. In this study, during Shiritori tasks using single\u2010event\u2010related NIRS, we analyzed oxyhemoglobin changes in an area, the peak amplitude, and latency, and compared them among four groups: AD group, HSMG, LSMG, and HG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>In the AD group, the area at left channel (Ch)9, 11, and 19, the area at right Ch22, and the peak ampulitude at left Ch11 and 19 and right Ch5,12, and 22 were significantly smaller than those in HSMG and HG. Furthermore, the latency of the AD group was significantly longer than that of HSMG and HG at all region of interests. However, no significant difference was observed between the AD group and LSMG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that analysis of changes in oxyhemoglobin during Shiritori tasks may be a useful neuropsychological index for the early diagnosis of AD. Detailed studies will be conducted in LSMG to facilitate the early introduction of NIRS as a screening tool for cognitive impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12226","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T05:43:14Z","timestamp":1485582194000},"page":"238-246","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of changes in oxyhemoglobin during Shiritori task in elderly subjects including those with Alzheimer\u2027s disease"],"prefix":"10.1111","volume":"17","author":[{"given":"Yusuke","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Kurume University School of Medicine  Kurume Japan"},{"name":"Cognitive and Molecular Research Institute of Brain Diseases Kurume University  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kurume 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