{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:38:15Z","timestamp":1783953495608,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Aim<\/jats:title>The relationship between declining performance, as measured by changes in reaction time, and declining cognitive function has not been critically studied. The aim of the present study was to investigate the association between reaction time during a task and cognitive ability in elderly T<\/jats:styled-content>aiwanese individuals.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients aged 65\u2009years or older with mild cognitive impairment (MCI<\/jats:styled-content>) (n<\/jats:italic>\u2009=\u200933) and A<\/jats:styled-content>lzheimer\u2019s disease (n<\/jats:italic>\u2009=\u200926) were recruited from the neurology clinic of a regional hospital in southern T<\/jats:styled-content>aiwan. In addition, 28 healthy controls aged 65\u2009years or older were recruited from the community. The cognitive performance of the study participants was assessed using the C<\/jats:styled-content>ognitive A<\/jats:styled-content>bilities S<\/jats:styled-content>creening I<\/jats:styled-content>nstrument (CASI<\/jats:styled-content>). A computer\u2010administered simple reaction time (SRT<\/jats:styled-content>) task and a flanker reaction time (FRT<\/jats:styled-content>) task were administered to assess participants\u2019 cognitive function. A non\u2010parametric K<\/jats:styled-content>ruskal\u2013W<\/jats:styled-content>allis test was performed to compare CASI<\/jats:styled-content> scores, SRT<\/jats:styled-content>, and FRT<\/jats:styled-content> among the three groups. anova<\/jats:sc> was also used to compare CASI<\/jats:styled-content> scores, inverse\u2010transformed SRT<\/jats:styled-content>, and inverse\u2010transformed FRT<\/jats:styled-content> among the three groups, with adjustment for age and years of education. Additionally, P<\/jats:styled-content>earson\u2019s partial correlation coefficients were used to assess the association of CASI<\/jats:styled-content> scores with inverse\u2010transformed SRT<\/jats:styled-content>, and inverse\u2010transformed FRT<\/jats:styled-content> within each of the three groups.<\/jats:p><\/jats:sec>Results<\/jats:title>Significant differences in CASI<\/jats:styled-content> scores, SRT<\/jats:styled-content>, and FRT<\/jats:styled-content> were found between the A<\/jats:styled-content>lzheimer\u2019s disease group and the other two groups, either with or without adjustment for age or education. The reaction time of patients with A<\/jats:styled-content>lzheimer\u2019s disease was significantly slower than the other two groups. Moreover, significant correlation between CASI<\/jats:styled-content> and FRT<\/jats:styled-content> was found in patients with MCI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Altered performance in a speed task was observed in patients with MCI<\/jats:styled-content>. The FRT<\/jats:styled-content> task should further be explored for its role as a marker for cognitive decline in elderly individuals, particularly in those with MCI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12247","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T08:56:50Z","timestamp":1488790610000},"page":"364-370","source":"Crossref","is-referenced-by-count":41,"title":["Cognitive decline and slower reaction time in elderly individuals with mild cognitive impairment"],"prefix":"10.1111","volume":"17","author":[{"given":"Ko\u2010Chia","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Psychology National Chung Cheng University Chiayi Taiwan"},{"name":"Clinical Psychology Center Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Chiayi 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