{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:18:20Z","timestamp":1767651500676},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Background<\/jats:title>Recent scientific reports have shown that older persons treated with antipsychotics for dementia\u2010related behavioural symptoms have increased mortality. However, the impact of these drugs prescribed during hospitalization has rarely been assessed. We aimed to investigate whether antipsychotics are associated with an increased risk of mortality during hospitalization and at 3\u2010month follow\u2010up in elderly inpatients.<\/jats:p><\/jats:sec>Methods<\/jats:title>We analyzed data gathered during two waves (2010 and 2012) by the REPOSI<\/jats:styled-content> (Re<\/jats:styled-content>gistro Po<\/jats:styled-content>literapie S<\/jats:styled-content>ociet\u00e0 I<\/jats:styled-content>taliana M<\/jats:styled-content>edicina I<\/jats:styled-content>nterna). All new prescriptions of antipsychotic drugs during hospitalization, whether maintained or discontinued at discharge, were collected, and logistic regression models were used to analyze their association with in\u2010hospital and 3\u2010month mortality. Covariates were age, sex, the S<\/jats:styled-content>hort B<\/jats:styled-content>lessed T<\/jats:styled-content>est (SBT<\/jats:styled-content>) score, and the C<\/jats:styled-content>umulative I<\/jats:styled-content>llness R<\/jats:styled-content>ating S<\/jats:styled-content>cale.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 2703 patients included in the study, 135 (5%) received new prescriptions for antipsychotic drugs. The most frequently prescribed antipsychotic during hospitalization and eventually maintained at discharge was haloperidol (38% and 36% of cases, respectively). Patients newly prescribed with antipsychotics were older and had a higher C<\/jats:styled-content>umulative I<\/jats:styled-content>llness R<\/jats:styled-content>ating S<\/jats:styled-content>cale comorbidity index both at admission and at discharge compared to those who did not receive a prescription. Of those prescribed antipsychotics, 71% had an SBT<\/jats:styled-content> score \u226510 (indicative of dementia), 12% had an SBT<\/jats:styled-content> score of 5\u20139 (indicative of questionable dementia); and 17% had an SBT<\/jats:styled-content> score <5 (indicative of normal cognition). In\u2010hospital mortality was slightly higher in patients prescribed antipsychotic drugs (14.3% vs 9.4%; P<\/jats:italic>\u2009=\u20090.109), but in multivariate analysis only male sex, older age, and higher SBT<\/jats:styled-content> scores were significantly related to mortality during hospitalization. At 3\u2010month follow\u2010up, only male sex, older age, and higher SBT<\/jats:styled-content> scores were associated with mortality.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We found that the prescription of antipsychotic drugs during hospitalization was not associated with in\u2010hospital or follow\u2010up mortality. Short\u2010term antipsychotic prescriptions (for acutely ill patients) may have a different effect than long\u2010term, repeated prescriptions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12263","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T20:52:42Z","timestamp":1496782362000},"page":"397-405","source":"Crossref","is-referenced-by-count":9,"title":["Antipsychotic prescription and mortality in hospitalized older persons"],"prefix":"10.1111","volume":"17","author":[{"given":"Deborah","family":"Chiesa","sequence":"first","affiliation":[{"name":"Post\u2010graduate School in Geriatrics University of Brescia Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Marengoni","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences University of Brescia Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Nobili","sequence":"additional","affiliation":[{"name":"Department of Neuroscience IRCCS \u2010 Istituto di Ricerche Farmacologiche Mario Negri Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Tettamanti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience IRCCS \u2010 Istituto di Ricerche Farmacologiche Mario Negri Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Pasina","sequence":"additional","affiliation":[{"name":"Department of Neuroscience IRCCS \u2010 Istituto di Ricerche Farmacologiche Mario Negri Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlotta","family":"Franchi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience IRCCS \u2010 Istituto di Ricerche Farmacologiche Mario Negri Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Codjo D.","family":"Djade","sequence":"additional","affiliation":[{"name":"Department of Neuroscience IRCCS \u2010 Istituto di Ricerche Farmacologiche Mario Negri Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Corrao","sequence":"additional","affiliation":[{"name":"Centre of Research for Effectiveness and Appropriateness in Medicine (C.R.E.A.M.), Di.Bi.M.I.S. University of Palermo Benfratelli Italy"},{"name":"Department of Internal Medicine National Relevance and High Specialization Hospital Trust, ARNAS Civico, Di Cirstina Benfratelli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Salerno","sequence":"additional","affiliation":[{"name":"Medicina Interna IRCCS Policlinico San Donato Milan Italy"},{"name":"Department of Medical and Surgery Sciences University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Marcucci","sequence":"additional","affiliation":[{"name":"Department of Geriatrics IRCCS Ca\u2019 Granda \u2010 Policlinico Maggiore Hospital Foundation Milan Italy"},{"name":"Department of Clinical Sciences and Community Health University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences University of Brescia Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Mannuccio","family":"Mannucci","sequence":"additional","affiliation":[{"name":"Bianchi Bonomi Haemophilic and Thrombosis Center IRCCS Ca\u2019 Granda \u2010 Policlinico Maggiore Hospital Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"REPOSI Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"29","article-title":"Utilization of antipsychotics in ambulatory elderly with dementia in an outpatient setting","volume":"29","author":"Sapra M","year":"2012","journal-title":"Fed Pract"},{"key":"e_1_2_5_3_1","unstructured":"FDA. 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