{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:12:00Z","timestamp":1788999120186,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u201cRedesigning Communities for Aged Society\u201d project"},{"name":"Grant-in-Aid for challenging Exploratory Research","award":["26630157"],"award-info":[{"award-number":["26630157"]}]},{"name":"Research Institute of Science and Technology for Society, Japan Science and Technology Agency"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Executive Interview (<jats:styled-content style=\"fixed-case\">EXIT<\/jats:styled-content>25), the <jats:styled-content style=\"fixed-case\">e<\/jats:styled-content>xecutive <jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>lock\u2010<jats:styled-content style=\"fixed-case\">d<\/jats:styled-content>rawing <jats:styled-content style=\"fixed-case\">t<\/jats:styled-content>ask (<jats:styled-content style=\"fixed-case\">CLOX<\/jats:styled-content>1), and the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>rontal <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>attery (<jats:styled-content style=\"fixed-case\">FAB<\/jats:styled-content>) are used to assess executive function at the bedside. These tests assess distinct psychometric properties. The aim of this study was to examine differences in the neural correlates of the <jats:styled-content style=\"fixed-case\">EXIT<\/jats:styled-content>25, <jats:styled-content style=\"fixed-case\">CLOX<\/jats:styled-content>1, and <jats:styled-content style=\"fixed-case\">FAB<\/jats:styled-content> based on <jats:styled-content style=\"fixed-case\">m<\/jats:styled-content>agnetic <jats:styled-content style=\"fixed-case\">r<\/jats:styled-content>esonance <jats:styled-content style=\"fixed-case\">i<\/jats:styled-content>maging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010eight subjects (30 with <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer\u2019s disease, 10 with mild cognitive impairment, and 18 healthy controls) participated in this study. Multiple regression analyses were performed to examine the brain regions correlated with the <jats:styled-content style=\"fixed-case\">EXIT<\/jats:styled-content>25, <jats:styled-content style=\"fixed-case\">CLOX<\/jats:styled-content>1, and <jats:styled-content style=\"fixed-case\">FAB<\/jats:styled-content> scores. Age, gender, and years of education were included as covariates. Statistical thresholds were set to uncorrected <jats:italic>P<\/jats:italic>\u2010values of 0.001 at the voxel level and 0.05 at the cluster level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">EXIT<\/jats:styled-content>25 score correlated inversely with the regional grey matter volume in the left lateral frontal lobe (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>rodmann areas 6, 9, 44, and 45). The <jats:styled-content style=\"fixed-case\">CLOX<\/jats:styled-content>1 score correlated positively with the regional grey matter volume in the right orbitofrontal cortex (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>rodmann area 11) and the left supramarginal gyrus (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>rodmann area 40). The <jats:styled-content style=\"fixed-case\">FAB<\/jats:styled-content> score correlated positively with the regional grey matter volume in the right precentral gyrus (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>rodmann area 6). The left lateral frontal lobe (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>rodmann area 9) and the right lateral frontal lobe (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>rodmann area 46) were identified as common brain regions that showed association with <jats:styled-content style=\"fixed-case\">EXIT<\/jats:styled-content>25, <jats:styled-content style=\"fixed-case\">CLOX<\/jats:styled-content>1, and <jats:styled-content style=\"fixed-case\">FAB<\/jats:styled-content> based only a voxel\u2010level threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study suggest that the <jats:styled-content style=\"fixed-case\">EXIT<\/jats:styled-content>25, <jats:styled-content style=\"fixed-case\">CLOX<\/jats:styled-content>1, and <jats:styled-content style=\"fixed-case\">FAB<\/jats:styled-content> may be associated with the distinct neural correlates of the frontal 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