{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:34:20Z","timestamp":1790008460910,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Anosognosia in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is a complicated, non\u2010unitary phenomenon. In a clinical setting, patients with mild <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> often preserve their awareness partially. We hypothesized that compensation, as well as neural dysfunction, could be correlated with anosognosia in mild <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The severity of anosognosia was evaluated using the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nosognosia <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire for <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ementia in 37\u2009subjects with mild <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> or mild cognitive impairment due to <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. The subjects also underwent single\u2010photon emission computed tomography with N\u2010isopropyl\u2010p\u2010[<jats:sup>123<\/jats:sup><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>]iodoamphetamine. Correlation between the severity of anosognosia and perfusion was assessed, and anosognosia (+) and (\u2212) groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The severity of anosognosia was relatively mild; the mean <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nosognosia <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire for <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ementia score was 6.76\u2009\u00b1\u200914.16. Subjects were divided into two groups: anosognosia (+) (<jats:italic>n<\/jats:italic>\u2009=\u200911) and anosognosia (\u2212) (<jats:italic>n<\/jats:italic>\u2009=\u200926). In the single\u2010photon emission computed tomography data analysis, the severity of anosognosia was correlated with both lower regional cerebral blood flows of the right prefrontal cortex and higher regional cerebral blood flows of the parietal cortex, especially the left temporo\u2010parietal junction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that anosognosia in mild <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> could be correlated with compensation as well as neural dysfunction. We speculate that this compensation may be related to the retrieval of outdated autobiographical memory.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12287","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:42:38Z","timestamp":1517964158000},"page":"81-88","source":"Crossref","is-referenced-by-count":12,"title":["Anosognosia in mild <scp>A<\/scp>lzheimer's disease is correlated with not only neural dysfunction but also compensation"],"prefix":"10.1111","volume":"18","author":[{"given":"Kenji","family":"Tagai","sequence":"first","affiliation":[{"name":"Department of Psychiatry Jikei University School of Medicine  Tokyo Japan"},{"name":"Department of Psychiatry Machida Municipal Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichiro","family":"Shinagawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Jikei University School of Medicine  Tokyo 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