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Our aim was to use virtual reality to determine the allocentric and egocentric memory deficits of subjects with single\u2010domain aMCI (aMCIsd) and multiple\u2010domain aMCI (aMCImd). For this purpose, we introduced an advanced virtual reality navigation task (VRNT) to distinguish these deficits in mild Alzheimer\u2019s disease (miAD), aMCIsd, and aMCImd.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The VRNT performance of 110 subjects, including 20 with miAD, 30 with pure aMCIsd, 30 with pure aMCImd, and 30 cognitively normal controls was compared. Our newly developed VRNT consists of a virtual neighbourhood (allocentric memory) and virtual maze (egocentric memory). Verbal and visuospatial memory impairments were also examined with Rey Auditory\u2010Verbal Learning Test and Rey\u2010Osterrieth Complex Figure Test, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that miAD and aMCImd subjects were impaired in both allocentric and egocentric memory, but aMCIsd subjects performed similarly to the normal controls on both tasks. The miAD, aMCImd, and aMCIsd subjects performed worse on finding the target or required more time in the virtual environment than the aMCImd, aMCIsd, and normal controls, respectively. Our findings indicated the aMCImd and miAD subjects, as well as the aMCIsd subjects, were more impaired in egocentric orientation than allocentric orientation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We concluded that VRNT can distinguish aMCImd subjects, but not aMCIsd subjects, from normal elderly subjects. The VRNT, along with the Rey Auditory\u2010Verbal Learning Test and Rey\u2010Osterrieth Complex Figure Test, can be used as a valid diagnostic tool for properly distinguishing different forms of aMCI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12301","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:43:03Z","timestamp":1517964183000},"page":"132-142","source":"Crossref","is-referenced-by-count":32,"title":["Using virtual reality to distinguish subjects with multiple\u2010 but not single\u2010domain amnestic mild cognitive impairment from normal elderly subjects"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1004-5339","authenticated-orcid":false,"given":"Alireza","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Neuroscience Research Center Baqiyatallah University of Medical Sciences  Tehran 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