{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T02:25:12Z","timestamp":1782354312556,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Unlike other behavioural and psychological symptoms of dementia, hyperphagia is less recognized among patients with Alzheimer\u2019s disease (AD). The prevalence of hyperphagia varies among studies, but there has been no systematic review or meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An extensive search on the literature on hyperphagia in AD published between 1\u2009January 1980 and 30 October 2017 was conducted. Data on the prevalence were retrieved. Meta\u2010analysis with a random effect model was performed to determine the pooled estimate of prevalence. Meta\u2010regression analysis was performed based on study characteristics, population demographics, or condition information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results from 20 studies were extracted. Twenty\u2010six reported cases of hyperphagia were identified. The mean age of onset was 70.7\u2009\u00b1\u20098.9\u2009years, with a male predominance (68.4%). Hyperphagia occurred in all stages of AD. Only eight studies reported the prevalence of hyperphagia. Meta\u2010analysis showed a pooled prevalence of hyperphagia of 18.6%. Publication bias may have been present. Meta\u2010regression showed that ethnicity accounted for the variance among studies (coefficient: \u22121.247 (95% confidence interval: \u22121.978 to \u22120.516), <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> analogue: 0.77, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hyperphagia occurs in all stages of AD. In this meta\u2010analysis of eight published studies, the prevalence of hyperphagia was 18.6%. In view of the possible publication bias, a large\u2010scale study on hyperphagia is recommended in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12316","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:42:44Z","timestamp":1517964164000},"page":"243-251","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of hyperphagia in Alzheimer\u2019s disease: a meta\u2010analysis"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5054-7106","authenticated-orcid":false,"given":"Yat\u2010Fung","family":"Shea","sequence":"first","affiliation":[{"name":"Department of Medicine, Li Ka Shing Faculty of Medicine University of Hong Kong, Queen Mary Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui\u2010Ching","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Li Ka Shing Faculty of Medicine University of Hong Kong, Queen Mary 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