{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:37:34Z","timestamp":1769092654268,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Alzheimer's disease (AD) pathology is highly prevalent in patients with idiopathic normal pressure hydrocephalus (iNPH), and the presence of AD pathology may involve regional cerebral blood flow (rCBF). In this study, we examined the relationship between rCBF and AD\u2010related biomarkers in the cerebrospinal fluid of iNPH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with iNPH (<jats:italic>n<\/jats:italic>\u2009=\u200939) were classified into groups with (iNPH\/AD+) (<jats:italic>n<\/jats:italic>=15) and without (iNPH\/AD\u2212) (<jats:italic>n<\/jats:italic>=24) high biomarker probability of AD (i.e. combined low amyloid \u03b2 42 and high total tau in the cerebrospinal fluid). rCBF was quantified in 17 regions of interest by N\u2010isopropyl\u2010p\u2010[<jats:sup>123<\/jats:sup>I]iodoamphetamine single\u2010photon emission computed tomography with the autoradiography method. We compared rCBF between the iNPH\/AD\u2212 and iNPH\/AD+ groups at baseline using a <jats:italic>t<\/jats:italic>\u2010test and then compared changes in rCBF after shunt surgery between the groups using a paired <jats:italic>t<\/jats:italic>\u2010test and two\u2010way repeated measures ANOVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, there were no significant differences in rCBF between the groups in most regions apart from the putamen. After shunt surgery, a significant increase in rCBF in the putamen, amygdala, hippocampus, and parahippocampal gyrus was observed in iNPH\/AD\u2212 patients. In iNPH\/AD+ patients, no significant improvement in rCBF was observed in any region. In repeated measures analysis of variance, a significant group\u2009\u00d7\u2009shunt interaction was observed in the parietal lobe, frontal lobe, posterior cingulate cortex, precuneus, lateral temporal lobe, amygdala, hippocampus, parahippocampal gyrus, and putamen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Improvement in rCBF after shunt surgery in iNPH\/AD+ patients may be poorer than that in iNPH AD\u2212 patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12435","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T23:49:26Z","timestamp":1553730566000},"page":"527-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cerebral blood flow and Alzheimer's disease\u2010related biomarkers in cerebrospinal fluid in idiopathic normal pressure hydrocephalus"],"prefix":"10.1111","volume":"19","author":[{"given":"Shingo","family":"Azuma","sequence":"first","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-8406","authenticated-orcid":false,"given":"Hiroaki","family":"Kazui","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Suita Japan"},{"name":"Department of Neuropsychiatry Kochi Medical School, Kochi University  Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Kanemoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Suita Japan"},{"name":"Department of Psychiatry Mizuma Hospital  Kaizuka Japan"},{"name":"Cognitive Reserve Research Center Osaka Kawasaki Rehabilitation University  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