{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:03:56Z","timestamp":1773867836733,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["17K10331"],"award-info":[{"award-number":["17K10331"]}]},{"name":"Zikei Institute of Psychiatry"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, depression with Lewy body pathology before the appearance of parkinsonism and cognitive dysfunction has been drawing attention. Low cardiac metaiodobenzylguanidine (MIBG) uptake is helpful for early differentiation of Lewy body disease (LBD) from late\u2010onset psychiatric disorders even before parkinsonism or dementia appears. In this study, we used MIBG uptake as a tool in suspected LBD, and evaluated the relationship of MIBG results to clinical characteristics and depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010two elderly inpatients with depression were included in this study. The Hamilton Depression Rating Scale (HDRS) was administered at admission, and <jats:sup>123<\/jats:sup>I\u2010MIBG cardiac scintigraphy was performed. Of 52 patients, 38 had normal and 14 had reduced MIBG uptake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Correlation analyses of the late phase heart\u2010to\u2010mediastinum (H\/M) ratio on the MIBG test and each item of the HDRS revealed that the H\/M ratio was significantly correlated with scores of \u2018agitation\u2019, \u2018anxiety\u2010somatic\u2019, and \u2018retardation\u2019 on the HDRS. Mean HDRS composite scores of \u2018somatic and psychic anxiety (Marcos)\u2019 and \u2018somatic anxiety\/somatization factor (Pancheri)\u2019 were higher in the low uptake group than in the normal uptake group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elderly patients with depression who manifested an obvious somatic anxiety tend to show low MIBG uptake, and are more likely to have Lewy body pathology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12439","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T08:16:03Z","timestamp":1551255363000},"page":"566-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical characteristics of elderly depressive patients with low metaiodobenzylguanidine 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