{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T18:33:09Z","timestamp":1782153189599,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neuropsychiatric symptoms (NPS) have been recognized as risk factors for conversion to dementia in patients with mild cognitive impairment (MCI). Early detection of NPS may allow for possible interventions in such patients. The present study used mild behavioural impairment to explore the role of NPS in a wide range of patients, from those who are cognitively intact to those with dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 234 patients with mild cognitive impairment were followed up for up to 3 years in a Japanese cohort study. Longitudinal data from patients who developed dementia during the study and those who did not were statistically analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cox regression analysis revealed that only abnormal perception and thought was significant in terms of dementia conversion. Moreover, mixed\u2010effects models indicated that baseline mild behavioural impairment symptoms did not affect cognitive trajectories such as changes in Mini\u2010Mental State Examination or Alzheimer's Disease Assessment Scale\u2010cognitive subscale scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that only abnormal perception and thought content were risk factors for dementia and that NPS may not lead to deterioration of cognitive function in patients with mild cognitive impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12447","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T06:33:46Z","timestamp":1553063626000},"page":"591-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Discrete effect of each mild behavioural impairment category on dementia conversion or cognitive decline in patients with mild cognitive impairment"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-8322","authenticated-orcid":false,"given":"Yuma","family":"Yokoi","sequence":"first","affiliation":[{"name":"Department of Psychiatry National Center of Neurology and Psychiatry  Kodaira Japan"},{"name":"University of Yamanashi, Faculty of Medicine, Graduate School  Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumasa","family":"Takano","sequence":"additional","affiliation":[{"name":"Integrative Brain Imaging Center National Center of Neurology and Psychiatry  Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masuhiro","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Center of Neurology and Psychiatry  Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Maruo","sequence":"additional","affiliation":[{"name":"Department of Clinical Trial and Clinical Epidemiology Tsukuba University  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Nakagome","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health National Center of Neurology and Psychiatry  Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Integrative Brain Imaging Center National Center of Neurology and Psychiatry  Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1316"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-101836"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03314.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14040480"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318203f208"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04181"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.01.006"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318211057d"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2187"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339955"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2014.301935"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61570-6"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31363-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1352"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2015.05.007"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150421"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.017"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.011"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.11.002"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_5_24_1","first-page":"186","article-title":"Reliability and validity of MMSE\u2010J (mini mental state of exam; 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