{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:44:33Z","timestamp":1769111073643,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Obesity contributes to the development of mild cognitive impairment, but the potential role of normal weight obesity in this disease has not been explored in humans. The aim of the study was to reveal the relationship between normal weight obesity and mild cognitive impairment in elderly individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study consisted of 360 patients with amnestic mild cognitive impairment and 360 cognitively normal controls. Normal weight obesity was defined as having metabolic syndrome but a normal weight. Metabolic health meant having no metabolic syndrome. Reverse transcription quantitative real\u2010time polymerase chain reaction was adopted to measure the messenger RNA expression of four cognitive\u2010related genes (amyloid precursor protein, cyclic adenosine monophosphate\u2010responsive element\u2010binding protein 1, sortilin\u2010related receptor 1, and synapsin I) in peripheral blood mononuclear cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Normal weight obesity was related to a higher risk of amnestic mild cognitive impairment (odds ratio\u2009=\u20093.14, 95% confidence interval: 2.13\u20134.60). In the patients, the expression of each gene in the peripheral blood mononuclear cells was linearly related to Mini\u2010Mental State Examination and Montreal Cognitive Assessment scores (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The expression of these genes in the patients with metabolic health deviated from the normal levels found in the controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and the deviations were more significant in the patients with normal weight obesity (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Normal weight obesity may be a potential risk factor for amnestic mild cognitive impairment in elderly. This relationship was reflected in the abnormal expression of several cognitive\u2010related genes in peripheral blood mononuclear cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12452","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T01:22:05Z","timestamp":1554513725000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship between normal weight obesity and mild cognitive impairment is reflected in cognitive\u2010related genes in human peripheral blood mononuclear cells"],"prefix":"10.1111","volume":"20","author":[{"given":"Shishuang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Geriatrics Tianjin Medical University General Hospital; Tianjin Geriatrics Institute  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Tianjin Medical University General Hospital; Tianjin Geriatrics Institute  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Tianjin Medical University General Hospital; Tianjin Geriatrics Institute  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Tianjin People's Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Nankai Center for Disease Control and Prevention  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-1819","authenticated-orcid":false,"given":"Ping","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Tianjin Medical University General Hospital; Tianjin Geriatrics Institute  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.13806"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004826"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0403-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4028"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182190d09"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150326"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-017-1493-x"},{"key":"e_1_2_7_9_1","first-page":"2534","article-title":"Metabolic syndrome in non\u2010obese Taiwanese: new definition of metabolically obese, normal\u2010weight individual","volume":"122","author":"Tsai CH","year":"2009","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31825d26b6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0246-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg221"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.88"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-013-1246-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2014.04.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4880"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1559767"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1722"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21514"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4547"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.02.031"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.218"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/618619"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.426536"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.8.1200"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503689102"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0800-4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(91)90137-M"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.04.001"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064750"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.3"}],"container-title":["Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/psyg.12452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T16:31:38Z","timestamp":1694104298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyg.12452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,5]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/psyg.12452"],"URL":"https:\/\/doi.org\/10.1111\/psyg.12452","archive":["Portico"],"relation":{},"ISSN":["1346-3500","1479-8301"],"issn-type":[{"value":"1346-3500","type":"print"},{"value":"1479-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,5]]},"assertion":[{"value":"2018-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}