{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:03:05Z","timestamp":1762376585229,"version":"3.40.5"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","award":["IIT\u201010018"],"award-info":[{"award-number":["IIT\u201010018"]}],"id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Late\u2010life depression (LLD) is associated with significant medical comorbidity, cognitive impairment, and suboptimal treatment response compared to depression experienced earlier in life. Levomilnacipran (LVM) is a novel antidepressant the effects of which on neuroplasticity have not yet been investigated. We investigated the effect of LVM on cortical thickness in a pilot randomised placebo\u2010controlled trial in LLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010nine adults (\u2265 60 years) with major depression (48.3% female; mean age = 71.5\u2009\u00b1\u20095.8\u2009years; mean education = 16.0\u2009\u00b1\u20091.7\u2009years) were randomised to either LVM or placebo for 12\u2009weeks. T1\u2010weighted images were acquired at baseline and 12\u2009weeks. Thirteen subjects (six LVM and seven placebo) completed the study. Group differences in cortical thickness change across the study period were evaluated, with age and total intracranial volume included as covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dropout rates did not differ significantly between groups. The LVM group had significantly more side effects, but no serious adverse events were reported. Lower LVM dose (\u2264\u200940\u2009mg) was better tolerated than higher doses (80\u2013120\u2009mg). Additionally, the LVM group showed a larger increase in cortical thickness in the right postcentral gyrus (primary somatosensory), supramarginal gyrus (sensory association region), and lateral occipital cortex (visual cortex) compared to the placebo group and greater reductions in the left insula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LVM may be less tolerable by older adults with depression and the effects on cortical thickness across sensory and sensory association regions may be related to the experience of side effects. Larger studies are necessary to evaluate treatment efficacy, tolerability, and neural effects of LVM in LLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12475","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T04:10:00Z","timestamp":1563855000000},"page":"140-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cortical thickness increases with levomilnacipran treatment in a pilot randomised double\u2010blind placebo\u2010controlled trial in late\u2010life depression"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5495-6348","authenticated-orcid":false,"given":"Beatrix","family":"Krause\u2010Sorio","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Semel Institute for Neuroscience University of California Los Angeles  Los Angeles California 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