{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:29:16Z","timestamp":1768314556019,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:00:00Z","timestamp":1594512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Early\u2010onset dementia (EOD) (defined as dementia onset before age 65) presents specific challenges and issues, adding to the negative impact of dementia on the health\u2010related quality of life (HRQOL) of both patients and their caregivers. However, very few published studies have specifically compared the HRQOL of caregivers of people with EOD and late\u2010onset dementia (LOD). This information is critical in allocating and prioritizing scarce health\u2010care resources. We aimed to assess the HRQOL of primary informal caregivers of community\u2010dwelling individuals with EOD in Singapore and compare it with that of caregivers of individuals with LOD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study of consecutive patient\u2013caregiver dyads from a tertiary dementia clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in disease severity were found between the 111 EOD and 235 LOD patient\u2013caregiver dyads. The mean Mental Component Summary score of the 36\u2010item Short\u2010Form Health Survey version 2 was significantly worse in caregivers of EOD patients than in LOD caregivers (mean: 41.42 vs 45.12, <jats:italic>P<\/jats:italic> = 0.001), although the mean Physical Component Summary scores were comparable (49.71 vs 49.53, <jats:italic>P<\/jats:italic> = 0.934). However, the impact of dementia early onset on caregivers' mental health diminished immediately after adjustment for the disease severity indicators, of which the Neuropsychiatric Inventory Questionnaire distress score was the only significant clinical factor (regression coefficient \u03b2 = \u22120.29, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The amount of variability in the HRQOL of the caregivers explained by patient and caregiver factors across all the models was rather small (adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 19.3% for the Mental Composite Score, 5.2% for Physical Composite Score).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Caregivers of EOD patients had worse mental health than LOD caregivers probably because individual with EOD have more behavioural disturbances. This reinforces the indispensable role of managing behavioural problems when caring for a family member with dementia, especially for EOD. HRQOL ideally needs to be assessed based on self\u2010report rather than inferences from indirect data such as the subjective caregiver burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12556","type":"journal-article","created":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T23:44:05Z","timestamp":1594597445000},"page":"608-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does health\u2010related quality of life in Asian informal caregivers differ between early\u2010onset dementia and late\u2010onset dementia?"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-2758","authenticated-orcid":false,"given":"Vivian W.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hospital Management, School of Public Health Fudan University  Shanghai China"},{"name":"Key Lab of Health Technology Assessment National Health Commission, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagaendran","family":"Kandiah","sequence":"additional","affiliation":[{"name":"Duke\u2010NUS Medical School, National University of Singapore (NUS)  Singapore Singapore"},{"name":"Duke\u2010NUS Graduate Medical School  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuling","family":"Lin","sequence":"additional","affiliation":[{"name":"Duke\u2010NUS Medical School, National University of Singapore (NUS)  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwee\u2010Lin","family":"Wee","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health National University of Singapore  Singapore Singapore"},{"name":"Department of Pharmacy, Faculty of Science National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200310000-00003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00422219"},{"key":"e_1_2_7_4_1","volume-title":"Encyclopedia of Quality of Life and Well\u2010Being Research","author":"Cesnales NI","year":"2014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607861003713224"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.02.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1935"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199909)14:9<784::AID-GPS16>3.0.CO;2-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2015.07.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093102"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000095750"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000117394"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080123"},{"key":"e_1_2_7_14_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM\u2010IV\u2010TR","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_7_15_1","unstructured":"ChanA OstbyeT MalhotraR HuAJ. 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